Impact of Nanotechnology on Socio-Economic Aspects: An Overview

Yadav, Sarita; Khan, Zulfequar Ahamad; Mishra, Brahmeshwar

doi:10.1166/rnn.2013.1026

Cited by 6 publications

(3 citation statements)

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“…On common ground, the easiest yet complicated way of avoiding the undesired immune complications is to understand the material behavior and interactions and predict the physiological response upon subjecting to the human ( Schaeublin et al, 2014 ; Beddoes et al, 2015 ; Zhou, 2015 ). To date, numerous studies were performed to assess the safety of NMs but the space between the in vitro and in vivo outcomes and clinical observations exists even today ( Yadav et al, 2013 ). To reduce this gap, the mechanistic events involved in producing the toxicity should be thoroughly studied, and advanced techniques need to be geared up to overcome present-day conventional method difficulties.…”

Section: Discussionmentioning

confidence: 99%

Novel Methods and Approaches for Safety Evaluation of Nanoparticle Formulations: A Focus Towards In Vitro Models and Adverse Outcome Pathways

et al. 2021

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Nanotoxicology is an emerging field employed in the assessment of unintentional hazardous effects produced by nanoparticles (NPs) impacting human health and the environment. The nanotoxicity affects the range between induction of cellular stress and cytotoxicity. The reasons so far reported for these toxicological effects are due to their variable sizes with high surface areas, shape, charge, and physicochemical properties, which upon interaction with the biological components may influence their functioning and result in adverse outcomes (AO). Thus, understanding the risk produced by these materials now is an important safety concern for the development of nanotechnology and nanomedicine. Since the time nanotoxicology has evolved, the methods employed have been majorly relied on in vitro cell-based evaluations, while these simple methods may not predict the complexity involved in preclinical and clinical conditions concerning pharmacokinetics, organ toxicity, and toxicities evidenced through multiple cellular levels. The safety profiles of nanoscale nanomaterials and nanoformulations in the delivery of drugs and therapeutic applications are of considerable concern. In addition, the safety assessment for new nanomedicine formulas lacks regulatory standards. Though the in vivo studies are greatly needed, the end parameters used for risk assessment are not predicting the possible toxic effects produced by various nanoformulations. On the other side, due to increased restrictions on animal usage and demand for the need for high-throughput assays, there is a need for developing and exploring novel methods to evaluate NPs safety concerns. The progress made in molecular biology and the availability of several modern techniques may offer novel and innovative methods to evaluate the toxicological behavior of different NPs by using single cells, cell population, and whole organisms. This review highlights the recent novel methods developed for the evaluation of the safety impacts of NPs and attempts to solve the problems that come with risk assessment. The relevance of investigating adverse outcome pathways (AOPs) in nanotoxicology has been stressed in particular.

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Section: Discussionmentioning

confidence: 99%

Novel Methods and Approaches for Safety Evaluation of Nanoparticle Formulations: A Focus Towards In Vitro Models and Adverse Outcome Pathways

et al. 2021

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“…Nanoscience and nanotechnology, which deals with science and technology at the nanoscale, have developed in such a way that it has already been used in several areas of knowledge, with social applications and economic impact [1]. From the Internet of Nano Things [2] to health benefits [3], exploiting the nanoworld has made a big impact.…”

Section: Introductionmentioning

confidence: 99%

Exploiting Nanomaterials for Optical Coherence Tomography and Photoacoustic Imaging in Nanodentistry

et al. 2022

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There is already a societal awareness of the growing impact of nanoscience and nanotechnology, with nanomaterials (with at least one dimension less than 100 nm) now incorporated in items as diverse as mobile phones, clothes or dentifrices. In the healthcare area, nanoparticles of biocompatible materials have already been used for cancer treatment or bioimaging enhancement. Nanotechnology in dentistry, or nanodentistry, has already found some developments in dental nanomaterials for caries management, restorative dentistry and orthodontic adhesives. In this review, we present state-of-the-art scientific development in nanodentistry with an emphasis on two imaging techniques exploiting nanomaterials: optical coherence tomography (OCT) and photoacoustic imaging (PAI). Examples will be given using OCT with nanomaterials to enhance the acquired imaging, acting as optical clearing agents for OCT. A novel application of gold nanoparticles and nanorods for imaging enhancement of incipient occlusal caries using OCT will be described. Additionally, we will highlight how the OCT technique can be properly managed to provide imaging with spatial resolution down to 10′s–100′s nm resolution. For PAI, we will describe how new nanoparticles, namely TiN, prepared by femtosecond laser ablation, can be used in nanodentistry and will show photoacoustic microscopy and tomography images for such exogenous agents.

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“…One of the most important areas of soft matter that gains attention from different fields of academia and industry of materials is the production of nanocomposites. 1 Among all compounds involved in nanotechnology, metal nanoparticles (NPs) are one of the most important composites, being ubiquitous as basic components in many products. 2 There are many metal NPs nowadays being used in different applications, however gold NPs (AuNPs) stand out because they have numerous physical, chemical and biological properties triggered by small changes in their nanometric size and morphology.…”

Section: Introductionmentioning

confidence: 99%

The impact of the polar core size and external organic media composition on micelle–micelle interactions: the effect on gold nanoparticle synthesis

et al. 2015

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Impact of Nanotechnology on Socio-Economic Aspects: An Overview

Cited by 6 publications

References 0 publications

Novel Methods and Approaches for Safety Evaluation of Nanoparticle Formulations: A Focus Towards In Vitro Models and Adverse Outcome Pathways

Novel Methods and Approaches for Safety Evaluation of Nanoparticle Formulations: A Focus Towards In Vitro Models and Adverse Outcome Pathways

Exploiting Nanomaterials for Optical Coherence Tomography and Photoacoustic Imaging in Nanodentistry

The impact of the polar core size and external organic media composition on micelle–micelle interactions: the effect on gold nanoparticle synthesis

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