Abstract:To evaluate the impact of N-acetyl-cysteine (NAC) on amputation stump perfusion and healing in patients with critical limbthreatening ischemia (CLTI). Background: Patients with CLTI are at increased risk of poor amputation site healing leading to increased procedure-associated morbidity. Methods: In a pilot, double-blind, placebo-controlled, randomized controlled trial, patients with CLTI undergoing major elective lower extremity amputation were randomized 1:1 to intravenous NAC (1200 mg twice-daily) or placeb… Show more
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