Impact of n-3 Docosapentaenoic Acid Supplementation on Fatty Acid Composition in Rat Differs Depending upon Tissues and Is Influenced by the Presence of Dairy Lipids in the Diet

Drouin, Gaëtan; Guillocheau, Étienne; Catheline, Daniel; Baudry, Charlotte; Ruyet, Pascale Le; Rioux, Vincent; Legrand, Philippe

doi:10.1021/acs.jafc.8b03069

Cited by 10 publications

(4 citation statements)

References 60 publications

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“…EPA is mostly studied and described to inhibit inflammation, cholesterol crystal formation, to reduce oxidative properties of atherogenic lipoproteins and to increase plaque instability (reviewed in References [88,89]). DPA can be metabolized to DHA and EPA [90] and also exhibits positive effects on cardio-metabolic parameters and improves lipid metabolism in mice [91,92]. DPA is less-extensively studied owing to the price and availability of the pure compound.…”

Section: Omega 3 Fatty Acidsmentioning

confidence: 99%

The Future of Lipid-Lowering Therapy

Zwol

Kuivenhoven

2019

JCM

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The recent introduction of inhibitors of proprotein convertase subtilisin/kexin 9 to lower low-density lipoprotein (LDL) cholesterol on top of statins or as monotherapy is rapidly changing the landscape of treatment of atherosclerotic cardiovascular disease (ASCVD). However, existing lipid-lowering drugs have little impact on lipoprotein(a) (Lp(a)) or plasma triglycerides, two other risk factors for ASCVD. This review summarizes the evidence and the rationale to target Lp(a) and triglycerides and provides an overview of currently tested strategies to lower Lp(a), apolipoprotein C-III and angiopoietin-like protein 3. In addition, it summarizes new findings on the use of omega-3 fatty acids (OM3FA) to fight ASCVD. With the exception of OM3FA supplementation, the promise of the experimental drugs discussed here depends on the long-term safety and efficacy of monoclonal antibodies and/or antisense oligonucleotides Clinical outcome trials will ultimately prove whether these new therapeutic modalities will reduce ASCVD risk.

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Section: Omega 3 Fatty Acidsmentioning

confidence: 99%

The Future of Lipid-Lowering Therapy

Zwol

Kuivenhoven

2019

JCM

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“…The dietary impact related to different organ functions might demand special attention [66,67]. It has been suggested that the heart would be sensitive to LA concentrations by interfering with SERCA2 activity [53,54].…”

Section: Plos Onementioning

confidence: 99%

Elevated plasma phospholipid n-3 docosapentaenoic acid concentrations during hibernation

Strandvik¹,

Qureshi²,

Painer³

et al. 2023

PLoS ONE

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Factors for initiating hibernation are unknown, but the condition shares some metabolic similarities with consciousness/sleep, which has been associated with n-3 fatty acids in humans. We investigated plasma phospholipid fatty acid profiles during hibernation and summer in free-ranging brown bears (Ursus arctos) and in captive garden dormice (Eliomys quercinus) contrasting in their hibernation patterns. The dormice received three different dietary fatty acid concentrations of linoleic acid (LA) (19%, 36% and 53%), with correspondingly decreased alpha-linolenic acid (ALA) (32%, 17% and 1.4%). Saturated and monounsaturated fatty acids showed small differences between summer and hibernation in both species. The dormice diet influenced n-6 fatty acids and eicosapentaenoic acid (EPA) concentrations in plasma phospholipids. Consistent differences between summer and hibernation in bears and dormice were decreased ALA and EPA and marked increase of n-3 docosapentaenoic acid and a minor increase of docosahexaenoic acid in parallel with several hundred percent increase of the activity index of elongase ELOVL2 transforming C20-22 fatty acids. The highest LA supply was unexpectantly associated with the highest transformation of the n-3 fatty acids. Similar fatty acid patterns in two contrasting hibernating species indicates a link to the hibernation phenotype and requires further studies in relation to consciousness and metabolism.

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“…For example, intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in the population is insufficient. These deficiencies may have negative effects on brain function, which may increase the risk of Alzheimer's disease in the elderly or the risk of cardiovascular or osteoarticular diseases [133][134][135]. Organic milk has been shown to be a more valuable source of EPA, DHA, and alpha-linolenic acid, even in winter [53].…”

Section: Fatty Acidsmentioning

confidence: 99%

Organic versus Conventional Raw Cow Milk as Material for Processing

Brodziak

Wajs

Zuba‐Ciszewska

et al. 2021

Animals

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Milk, as one of the basic raw materials of animal origin, must be of adequate hygienic and physicochemical quality for processing. The aim of the article was to compare the quality of raw milk from three production systems, intensive, traditional (together referred to as conventional), and organic, as material for processing, as well as the quality of products made from it. Particular attention was focused on hygienic quality (somatic cell count and total bacterial count), physical characteristics (acidity), basic nutritional value (content of dry matter, total protein, casein, fat, and lactose), content of health-promoting substances (whey proteins, fatty acids, vitamins, and minerals), and technological parameters (rennet clotting time, heat stability, and protein-to-fat ratio). Research assessing the quality of organic milk and dairy products is significantly less extensive (if available at all) than for milk from conventional production (intensive and traditional). The available reports indicate that raw milk from organic farms is more valuable, especially in terms of the content of health-promoting compounds, including vitamins, fatty acids, whey proteins, and minerals. This applies to organic dairy products as well, mainly cheese and yoghurt. This is explained by the fact that organic farming requires that animals are kept in the pasture. However, the hygienic quality of the raw milk, and often the products as well, raises some concerns; for this reason, organic milk producers should be supported in this regard, e.g., through consultancy and training in Good Hygienic Practices. Importantly, milk production in the traditional and organic systems is in line with the concept of the European Green Deal.

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Impact of n-3 Docosapentaenoic Acid Supplementation on Fatty Acid Composition in Rat Differs Depending upon Tissues and Is Influenced by the Presence of Dairy Lipids in the Diet

Cited by 10 publications

References 60 publications

The Future of Lipid-Lowering Therapy

The Future of Lipid-Lowering Therapy

Elevated plasma phospholipid n-3 docosapentaenoic acid concentrations during hibernation

Organic versus Conventional Raw Cow Milk as Material for Processing

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