Impact of muscle mass loss assessed by computed tomography on the outcome of allogeneic stem cell transplantation

Nagayama, Takashi; Fujiwara, Shin-ichiro; Kikuchi, Tomohiro; Onda, Kakusaburo; Murahashi, Rui; Nakashima, Hirotomo; Ikeda, Takashi; Matsuoka, Shinji; Kawaguchi, Shinichiro; Toda, Yumiko; Ito, Shoko; Ban, Tetsuaki; Umino, Kento; Minakata, Daisuke; Nakano, Hirofumi; Yamasaki, Ryo; Morita, Kaoru; Ashizawa, Masahiro; Yamamoto, Chiyo; Hatano, Kaoru; Sato, Kazuya; Oh, Iekuni; Ohmine, Ken

doi:10.1080/10428194.2022.2034159

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…Indeed, body mass composition itself could impact HSCT outcome, and GM composition could also influence the complex metabolic pathways regulating body composition. Muscle mass is an independent predictor of survival after HSCT, with sarcopenia associated with worse disease-free and overall survival ( 45 , 46 ). The GM, and particularly its metabolites, play an important role in muscle metabolism, affecting skeletal muscle mass and function ( 47 ).…”

Section: The Relationship Between Nutritional Status and Gut Microbiotamentioning

confidence: 99%

Nutritional modulation of the gut microbiome in allogeneic hematopoietic stem cell transplantation recipients

Muratore¹,

Leardini²,

Baccelli³

et al. 2022

Front. Nutr.

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Allogeneic hematopoietic stem cell transplantation (allo-HSCT) represents a potentially curative strategy for many oncological and non-oncological diseases, but it is associated with marked morbidity and mortality. The disruption of gut microbiota (GM) eubiosis has been linked to major allo-HSCT complications, including infections and acute graft vs. host disease (aGvHD), and correlates with mortality. This increasing knowledge on the role of the GM in the allo-HSCT procedure has led to fascinating ideas for modulating the intestinal ecosystem in order to improve clinical outcomes. Nutritional strategies, either by changing the route of nutritional supplementation or by administering specific molecules, are increasingly being considered as cost- and risk-effective methods of modulating the GM. Nutritional support has also emerged in the past several years as a key feature in supportive care for allo-HSCT recipients, and deterioration of nutritional status is associated with decreased overall survival and higher complication rates during treatment. Herein we provide a complete overview focused on nutritional modulation of the GM in allo-HSCT recipients. We address how pre transplant diet could affect GM composition and its ability to withstand the upsetting events occurring during transplantation. We also provide a complete overview on the influence of the route of nutritional administration on the intestinal ecosystem, with a particular focus on the comparison between enteral and parenteral nutrition (PN). Moreover, as mounting evidence are showing how specific components of post-transplant diet, such as lactose, could drastically shape the GM, we will also summarize the role of prebiotic supplementation in the modulation of the intestinal flora and in allo-HSCT outcomes.

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Section: The Relationship Between Nutritional Status and Gut Microbiotamentioning

confidence: 99%

Nutritional modulation of the gut microbiome in allogeneic hematopoietic stem cell transplantation recipients

Muratore¹,

Leardini²,

Baccelli³

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

show abstract

Prognostic Impact of Quantifying Sarcopenia and Adipopenia by Chest CT in Severe Aplastic Anemia Patients Treated With Allogeneic Hematopoietic Stem Cell Transplantation

Chen¹,

Yuan²,

Guo³

et al. 2023

Academic Radiology

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Impact of muscle mass loss assessed by computed tomography on the outcome of allogeneic stem cell transplantation

Cited by 2 publications

References 15 publications

Nutritional modulation of the gut microbiome in allogeneic hematopoietic stem cell transplantation recipients

Nutritional modulation of the gut microbiome in allogeneic hematopoietic stem cell transplantation recipients

Prognostic Impact of Quantifying Sarcopenia and Adipopenia by Chest CT in Severe Aplastic Anemia Patients Treated With Allogeneic Hematopoietic Stem Cell Transplantation

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