Impact of multiple sclerosis on quality of life: Comparison with systemic lupus erythematosus

Contentti, Edgar Carnero; Genco, Néstor David; Hryb, Javier; Caspi, Mercedes; Chiganer, Edson; Pace, José Luis Di; López, Pablo A.; Lessa, Carmen; Caride, Alejandro; Perassolo, Mónica

doi:10.1016/j.clineuro.2017.10.032

Cited by 11 publications

(2 citation statements)

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“…The World Health Organization defined health as, “a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity” (10). Because health is a difficult concept to standardize, the Short Form-36 (SF-36) questionnaire is often used to obtain qualitative measures of self-perceived health and QOL in 8 domains across multiple populations (7,11,12).…”

Section: Introductionmentioning

confidence: 99%

Quality of Life, Social, and Emotional Aspects of Being Diagnosed With Multiple Sclerosis: What's Grit got to do With it?

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2022

Journal of Patient Experience

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The purpose of this study was to determine the extent to which grit influences the quality of life (QOL) in patients diagnosed with multiple sclerosis (MS). Mixed-methods included a survey (n = 51) via Qualtrics utilizing the Grit Scale, Short Form-36 (SF-36), and general demographic questions and phenomenological interviews (n = 14). Quantitative data were analyzed using the SPSS25. Qualitative data were analyzed using whole-parts-whole analysis. The average grit score for participants diagnosed with MS was 3.8 ± 0.5. Moderate correlations existed between grit scores and emotional role limitations (r = .542, P < .001), emotional well-being (r = .542, P < .001), and social functioning (r = .448, P < .001). Common themes that emerged from the phase II interviews included (a) an initial shock or relief factor, (b) an identity shift, and (c) advocacy and victories. Higher levels of grit correlate with a better QOL.

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Section: Introductionmentioning

confidence: 99%

Quality of Life, Social, and Emotional Aspects of Being Diagnosed With Multiple Sclerosis: What's Grit got to do With it?

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2022

Journal of Patient Experience

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“…Physical disability and upper extremity function are hallmark symptoms of Multiple Sclerosis (MS), and are among the most important factors affecting quality of life [1,2]. Another common symptom is cognitive dysfunction, affecting approximately 40% to 65% of patients and impacting employment, daily living skills, and overall quality of life [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a connectivity-based imaging metric that reflects functional decline in Multiple Sclerosis

et al. 2021

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Cognitive impairment is a common symptom in individuals with Multiple Sclerosis (MS), but meaningful, reliable biomarkers relating to cognitive decline have been elusive, making evaluation of the impact of therapeutics on cognitive function difficult. Here, we combine pathway-based MRI measures of structural and functional connectivity to construct a metric of functional decline in MS. The Structural and Functional Connectivity Index (SFCI) is proposed as a simple, z-scored metric of structural and functional connectivity, where changes in the metric have a simple statistical interpretation and may be suitable for use in clinical trials. Using data collected at six time points from a 2-year longitudinal study of 20 participants with MS and 9 age- and sex-matched healthy controls, we probe two common symptomatic domains, motor and cognitive function, by measuring structural and functional connectivity in the transcallosal motor pathway and posterior cingulum bundle. The SFCI is significantly lower in participants with MS compared to controls (p = 0.009) and shows a significant decrease over time in MS (p = 0.012). The change in SFCI over two years performed favorably compared to measures of brain parenchymal fraction and lesion volume, relating to follow-up measures of processing speed (r = 0.60, p = 0.005), verbal fluency (r = 0.57, p = 0.009), and score on the Multiple Sclerosis Functional Composite (r = 0.67, p = 0.003). These initial results show that the SFCI is a suitable metric for longitudinal evaluation of functional decline in MS.

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Health-related quality of life and depressive symptoms in Friedreich ataxia

et al. 2019

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Impact of multiple sclerosis on quality of life: Comparison with systemic lupus erythematosus

Cited by 11 publications

References 40 publications

Quality of Life, Social, and Emotional Aspects of Being Diagnosed With Multiple Sclerosis: What's Grit got to do With it?

Quality of Life, Social, and Emotional Aspects of Being Diagnosed With Multiple Sclerosis: What's Grit got to do With it?

Evaluation of a connectivity-based imaging metric that reflects functional decline in Multiple Sclerosis

Health-related quality of life and depressive symptoms in Friedreich ataxia

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