Impact of multiple deprivations on detection, progression and interventions in small renal masses (less than 4 cm) in a population based study

Leonard, M.; Tait, Campbell; Gillan, Angela; Prasad, Bhavan; Byrne, D. J.; Nabi, Ghulam

doi:10.1016/j.ejso.2013.06.014

Cited by 11 publications

(10 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We have used a large multi-institutional data with validation of part of the cohort by electronic cross-linkage methodology as described previously [ 34 , 35 ]. Although all the centres have a strong interest in and experience of endoscopic diagnosis of upper tract urothelial cancers, lack of randomisation to PNU, no PNU biopsies from normal appearing ureters to confirm diagnosis of CIS prior to nephroureterectomy, lack of information on whether CIS was de nova or concomitant, and a small number of patients with CIS on PNU are some of limitations of the present study.…”

Section: Discussionmentioning

confidence: 99%

Carcinoma In Situ Is Significantly Underdetected by Prenephroureterectomy Ureteroscopy in the Management of Upper Tract Urothelial Cancers

Gillan

El‐Mokadem

Prasad

et al. 2015

BioMed Research International

View full text Add to dashboard Cite

Objective. Diagnostic reliability of prenephroureterectomy ureteroscopy (PNU) for the detection of upper tract carcinoma in situ (CIS) remains unproven in particular and underreported in general. Methods. Patients who underwent radical nephroureterectomy (RNU) in a large multicentre retrospective study for upper tract transitional cell carcinoma (UT-TCC) between January 2002 and December 2013 were identified from our hospitals databases. PNU appearances, stage, and grade of ureteroscopic biopsy were compared with final histology results of RNU to assess the diagnostic reliability of PNU for carcinoma in situ (CIS). Results. Three hundred patients underwent RNU for UT-TCC. 106 (106/300; 35.3%) of the cohort had PNU using white light with biopsies taken in most (92/106; 86.7%). Postnephroureterectomy histology of the cohort showed CIS in 65 (65/300; 21.6%) patients. Thirty nine of patients with CIS (39/65; 60%) had prenephroureterectomy ureteroscopy biopsies. Out of ten patients with CIS on ureteroscopic biopsies, six did not show CIS on final histopathology (6/10; 60%). Moreover, grading and staging on PNU biopsies of obvious tumours showed a significant nonconcordance with final histopathology of RNU specimen (P = 0.02). Overall survival was also shorter in patients with CIS compared with those without; this showed strong statistical significance (P = 0.004). Conclusions. There is a high incidence of CIS in upper tract with significant underdetection and discordance rate between the histopathology of biopsy samples obtained by white light PNU and resected specimen of radical nephroureterectomy. The presence of concomitant CIS and high stage disease in the upper tract TCC carried a poor prognosis following radical nephroureterectomy.

show abstract

Section: Discussionmentioning

confidence: 99%

Carcinoma In Situ Is Significantly Underdetected by Prenephroureterectomy Ureteroscopy in the Management of Upper Tract Urothelial Cancers

Gillan

El‐Mokadem

Prasad

et al. 2015

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…The word file contained unique identifier number (CHI), demographic details, type of presentation, stage, histology, grade, radiological finding and final consensus decision of the multidisciplinary team. Our previous reports have validated the data quality of this process including record linkage methodology through a common identifier (CHI number) using a deterministic record linkage strategy [13][14][15]. Figure 1 summarises the study cohort, flow and systems used for record-linkage.…”

Section: Study Cohortmentioning

confidence: 99%

“…The population of the area was stable with less than 1% migration and more than 98% registered with NHS through a unique identifier called CHI number (Community Health Index-CHI). For various indications, 160,820 abdominal imaging tests (CT, MRI, US) were carried out in a population of 118,600 as reported previously [13]. Since 2005, all new primary renal cancers in the region were managed within a single Health Board and each case was recorded at local multidisciplinary meetings run by a local Urological Cancers Network (TUCAN).…”

Section: Study Cohortmentioning

confidence: 99%

“…A group of patients diagnosed with bilateral small renal masses were compared with those diagnosed with unilateral disease using propensity score matching for variables known to influence growth such as size, location etc. Progression was defined as any increase in size on followup or change in tumour characteristic on follow-up imaging as described previously [13,15].…”

Section: Study Cohortmentioning

confidence: 99%

See 1 more Smart Citation

Outcomes of synchronous and metachronous bilateral small renal masses (< 4 cm): a population-based cohort study

et al. 2018

View full text Add to dashboard Cite

show abstract

“…This healthcare region is served by 75 general practices and a single tertiary urological cancer service. All newly diagnosed cancers are reviewed by a local multidisciplinary team, and the meeting records are stored in a database called the “Tayside Urological Cancer Network Database” . Study data was collected using a validated record‐linkage methodology and a unique single number (CHI), as described by our group (see Fig.…”

Section: Patients and Materialsmentioning

confidence: 99%

Videotaping of surgical procedures and outcomes following extraperitoneal laparoscopic radical prostatectomy for clinically localized prostate cancer

Paterson

Mcluckie²,

Chin

et al. 2016

Journal of Surgical Oncology

View full text Add to dashboard Cite

Background Video‐recording of emerging minimally invasive surgical procedures is likely to become an integral component of patient record‐keeping in the future for prostate cancer treatment. No prior work has shown the impact of videotaping of laparoscopic prostatectomy on patient outcomes. Our aim was to determine correlation between independent peer review of videotaping quality scores of extraperitoneal laparoscopic prostatectomy (ELRP) with complications, re‐admissions, functional, and early oncological outcomes. Study Design, Setting, and Participants We conducted a single‐institution prospective cohort study comparing videotaping quality scores with the outcomes of ELRP in men with localized prostate cancer. Videotaping of surgical procedures were scored by two experienced laparoscopic surgeons using a validated scoring method. Validated record‐linkage methodology and self‐reported questionnaires were used to assess surgical complications, re‐admissions, functional, and oncological outcomes based on a common identifier called as community health index (CHI) number. Pearson correlation coefficients were calculated between the different covariates with statistical significance considered at P < 0.05. Multivariate analyses assessed oncological outcomes (positive surgical margins/biochemical recurrence), post‐operative complications, and re‐admission into hospital following initial hospital discharge with quality of surgical procedure. Results 200 men were recruited into the study. 51 (25.5%) participants had post‐operative complications. Record‐linkage methodology identified 18 (9%) participants had re‐admissions within 90 days of the procedure. 13 (6.5%) of these men required percutaneous drainage with hospital stay following re‐admissions ranged between 3 and 12 days. 10 (5.0%) participants had intra/peri‐operative complications. 23 (11.5%) men reported to primary care physicians for various indications. Higher quality surgical technique videotaped scores (assessed by independent peer review) had a significant correlation with early continence recovery at 3 months post‐procedure, (P = 0.013), but lost statistical significance with overall continence at 1 year. No statistical correlation was observed between videotaped scores and oncological outcomes (positive surgical margins/biochemical recurrence), post‐operative complications, and readmission into hospital. Conclusions Quality of surgical procedure assessed by independent third party videotaping score predicted early resumption of continence following extraperitoenal laparoscopic radical prostatectomy, however, it did not predict complications, oncological or functional outcome as assessed using patient reported outcomes at 12 months. J. Surg. Oncol. 2016;114:1016–1023. © 2016 Wiley Periodicals, Inc.

show abstract

Impact of multiple deprivations on detection, progression and interventions in small renal masses (less than 4 cm) in a population based study

Cited by 11 publications

References 20 publications

Carcinoma In Situ Is Significantly Underdetected by Prenephroureterectomy Ureteroscopy in the Management of Upper Tract Urothelial Cancers

Carcinoma In Situ Is Significantly Underdetected by Prenephroureterectomy Ureteroscopy in the Management of Upper Tract Urothelial Cancers

Outcomes of synchronous and metachronous bilateral small renal masses (< 4 cm): a population-based cohort study

Videotaping of surgical procedures and outcomes following extraperitoneal laparoscopic radical prostatectomy for clinically localized prostate cancer

Contact Info

Product

Resources

About