Impact of Multilevel Surgical Treatment on Mean Platelet Volume in Patients With Obstructive Sleep Apnea Syndrome

Günbey, Emre; Karabulut, İsmail; Karabulut, Hayriye; Zaim, Murat

doi:10.1097/scs.0000000000001556

Cited by 12 publications

(8 citation statements)

References 19 publications

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“…Another study by Kurt et al reported a meaningful correlation between PDW and AHI (17). Moreover in some studies, it was proposed that treatment with continuous positive airway pressure (CPAP) devices and surgical intervention significantly reduce MPV and PDW values in patients with severe OSA (10)(11)(12)24). On contrary, almost similar number of study reported no relationship between MPV and OSA, and between PDW and OSA (13)(14)(15)(16)(17)(18).…”

Section: Discussionmentioning

confidence: 81%

Platelet indices in obstructive sleep apnea: the role of mean platelet volume, platelet distribution widht and plateletcrit

Bülbül

Özgür²,

Örem³

2016

Tuberk Toraks

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SUMMARYPlatelet indices in obstructive sleep apnea: the role of mean platelet volume, platelet distribution widht and plateletcrit Introduction: Because studies report controversial findings of mean platelet volume (MPV) and platelet distribution width (PDW), we aimed to investigate platelet indices in patients with obstructive sleep apnea (OSA). Materials and Methods:One hundred seventy three patients with OSA and 43 control subjects included in analyses. Patients with an apnea-hypopnea index (AHI) ≥ 5 were considered to have OSA and an AHI < 5 were considered as control. Platelet indices (MPV, PDW, plateletcrit) were obtained from routine analysis of blood samples using an automated blood cell counter. OSA, especially in severe OSA when compared to control group (16.80 ± 0.56 vs. 16.21 ± 1.51, p= 0.015 and 16.82 ± 0.06 vs.16.21 ± 1.51, p= 0.014, respectively). Correlation analysis showed a significant but a weak correlation between the PDW and AHI (r= 0.161, p= 0.018) and the PDW and the desaturation index (r= 0.171, p= 0.016). The ROC curve analysis showed that the optimal cut-off value, distinguishing patients with OSA from those in control group, for PDW was 16.62 (sensitivity 57.8%, specificity 58.1%, AUROC 0.60, p= 0.042) Results: Among platelet indices, only PDW was higher in patients with . After the exclusion of patients with comorbid diseases (cardiovascular diseases, diabetes mellitus and chronic inflammatory diseases), we also found weak but a significant correlation between PDW and AHI (r= 0.179, p= 0.040). Conclusion: In conclusion, among the platelet indices, only PDW was found to be higher in patients with

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Section: Discussionmentioning

confidence: 81%

Platelet indices in obstructive sleep apnea: the role of mean platelet volume, platelet distribution widht and plateletcrit

Bülbül

Özgür²,

Örem³

2016

Tuberk Toraks

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“…Increased platelet activity could contribute to an increased atherothrombotic risk in patients with OSA. CPAP reported to cause a significant decrease in the MPV and PDW values in patients with OSA,9, 10 and this suggested that early diagnosis and CPAP therapy may confer some cardioprotective effects through the reduction of platelet activation.…”

Section: Discussionmentioning

confidence: 94%

“…The result of the study showed that OSA is independently associated with subsequent major adverse cardiac and cerebrovascular events, claiming the need for additional studies to evaluate of therapeutic approaches to mitigate OSA‐associated risk 5. Interestingly, some clinical studies showed that severe OSA significantly increases the level of MPV and platelet reactivity, and CPAP therapy significantly reversed this effect 7, 9. Rahangdale et al have previously reported in a small cohort ADP‐induced platelet aggregation was markedly increased in OSA patients 7.…”

Section: Discussionmentioning

confidence: 99%

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Impact of Obstructive Sleep Apnea on Platelet Function Profiles in Patients With Acute Coronary Syndrome Taking Dual Antiplatelet Therapy

Gong

Xiao

Fan

et al. 2018

JAHA

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BackgroundObstructive sleep apnea (OSA) is a novel risk factor for acute coronary syndrome (ACS). Several studies have shown OSA to be associated with induced platelet reactivity. However, whether OSA have effects on platelet function profiles in ACS patients taking dual antiplatelet therapy remains unexplored.Methods and ResultsThis was a cross‐sectional observational study, in which ACS patients taking maintenance aspirin and clopidogrel therapy were included. OSA was defined as an apnea‐hypopnea index ≥15 events/hour. The inhibitory rate of arachidonic acid or adenosine diphosphate pathway were assessed with thrombelastography and defined patients with high residual on‐treatment platelet reactivity. Platelet indices were obtained from routine analysis of blood samples using an automated blood cell counter. A total of 127 ACS patients taking dual antiplatelet therapy were analyzed. Platelet volume indices, including mean platelet volume and platelet large cell ratio, were significantly increased in patients with OSA. Patients with OSA (n=68) had significantly lower inhibitory rate of adenosine diphosphate receptor pathway (P=0.028) compared with those without (n=59). After adjustment for potential confounders, patients with OSA were more likely to have high residual on‐treatment platelet reactivity after clopidogrel therapy (adjusted odds ratio: 3.25, 95% confidence interval: 1.19–8.87, P=0.021).ConclusionsIn ACS patients taking dual antiplatelet therapy, OSA is associated with an increased level of platelet volume indices, reduced clopidogrel‐induced antiplatelet effects and a greater prevalence of high residual on‐treatment platelet reactivity.

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“…Multilevel surgery targeting the retropalatal and tongue-base was effective in reducing mean platelet volume and apnea hypopnea index. Mean platelet volume is known to be predictors of cardiovascular diseases, hypertension, and stroke [115]. Surgery is effective at improving overnight polysomnography in obese children [116].…”

Section: Invasive Treatmentmentioning

confidence: 99%

Urological Manifestations of Obstructive Sleep Apnea Syndrome: A Review of Current Literature

Dagur¹,

Warren²,

Ambroise³

et al. 2015

Transl Biomed

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Sleep apnea syndrome is a common health issue that is frequently found in patients with obesity associated cardiovascular and respiratory disorders. Patients with sleep apnea suffer from hypoxia during sleep, resulting in metabolic dysfunction of various organ specific symptoms. Obstructive sleep apnea syndrome results in critical psychological symptoms, which include depression and suicidal tendencies. Sleep apnea syndrome carries significant morbidity and mortality that is frequently ignored by healthcare providers. A high percentage of sleep apnea patients suffer from genitourinary symptoms, such as frequency, nocturia, erectile dysfunction, enuresis, and overactive bladder. Current concepts of sleep apnea, as related to urological health issues, are discussed to facilitate treatment options of sleep apnea syndrome. Current literature is reviewed related to genitourinary symptoms.

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Impact of Multilevel Surgical Treatment on Mean Platelet Volume in Patients With Obstructive Sleep Apnea Syndrome

Abstract: One-stage multilevel surgery targeting the obstruction at the retropalatal and tongue-base levels was found to be effective in decreasing AHI and MPV. Mean platelet volume may be a new index to indicate the success of OSAS surgery.

Cited by 12 publications

References 19 publications

Platelet indices in obstructive sleep apnea: the role of mean platelet volume, platelet distribution widht and plateletcrit

Platelet indices in obstructive sleep apnea: the role of mean platelet volume, platelet distribution widht and plateletcrit

Impact of Obstructive Sleep Apnea on Platelet Function Profiles in Patients With Acute Coronary Syndrome Taking Dual Antiplatelet Therapy

Urological Manifestations of Obstructive Sleep Apnea Syndrome: A Review of Current Literature

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