Impact of mucosal inflammation on risk of colorectal neoplasia in patients with ulcerative colitis: a systematic review and meta-analysis

Flores, Brisas; OʼConnor, Anthony; Moss, Alan C.

doi:10.1016/j.gie.2017.07.028

Cited by 72 publications

(47 citation statements)

References 114 publications

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“…Finally, in a recent meta-analysis of 1443 patients, the presence of endoscopic or histologic inflammation as well as histologic inflammation alone increased the risk of colorectal neoplasia (OR, 3.53; 95% CI, 2.59-4.80 and OR, 2.6; 95% CI, 1.49-4.46, respectively). 47…”

Section: Association Between Histologic Inflammation and The Developmmentioning

confidence: 99%

The emerging role of histologic disease activity assessment in ulcerative colitis

Pai

Jairath

Casteele

et al. 2018

Gastrointestinal Endoscopy

100

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Section: Association Between Histologic Inflammation and The Developmmentioning

confidence: 99%

The emerging role of histologic disease activity assessment in ulcerative colitis

Pai

Jairath

Casteele

et al. 2018

Gastrointestinal Endoscopy

100

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“…Patients without signs of previous or ongoing inflammation have acquired less cumulative inflammatory damage over time. A decreased mutational burden translates into a decreased risk of developing aCRN 25. Moreover, endoscopically active disease, strictures and postinflammatory polyps all affect visibility during colonoscopy and thus the sensitivity of the colonoscopy itself for dysplasia and CRC detection.…”

Section: Discussionmentioning

confidence: 99%

Consecutive negative findings on colonoscopy during surveillance predict a low risk of advanced neoplasia in patients with inflammatory bowel disease with long-standing colitis: results of a 15-year multicentre, multinational cohort study

Hove

Shah

Shaffer

et al. 2018

Gut

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“…Screening techniques included standard white-light colonoscopy (SD-WLE), high-definition white light colonoscopy (HD-WLE), dye chromoendoscopy (DCE), virtual chromoendoscopy (NBI, i-Scan, and FICE) and AFI. Patients presented with UC in the form of pancolitis or left colitis or DC with involvement of at least one-third or more of a segment of the colon, with a disease time of more than 8 years, or with primary sclerosing cholangitis, regardless of disease time [26][27][28]. There was no restriction of period, country or language of publication.…”

Section: Eligibility Criteriamentioning

confidence: 99%

Surveillance in inflammatory bowel disease: is chromoendoscopy the only way to go? A systematic review and meta-analysis of randomized clinical trials

et al. 2020

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Background and study aims Ulcerative colitis (UC) and Crohn’s disease (CD) have higher risk of colorectal cancer (CRC). Guidelines recommend dysplasia surveillance with dye-spraying chromoendoscopy (DCE). The aim of this systematic review and meta-analysis was to review all randomized clinical trials (RCTs) available and compare the efficacy of different endoscopic methods of surveillance for dysplasia in patients with UC and CD. Methods Databases searched were Medline, EMBASE, Cochrane and SCIELO/LILACS. It was estimated the risk difference (RD) for dichotomous outcomes (number of patients diagnosed with one or more dysplastic lesions, total number of dysplastic lesions diagnosed and number of dysplastic lesions detected by targeted biopsies) and mean difference for continuous outcomes (procedure time). Results This study included 17 RCTs totaling 2,457 patients. There was superiority of DCE when compared to standard-definiton white light endoscopy (SD-WLE). When compared with high-definition (HD) WLE, no difference was observed in all outcomes (number of patients with dysplasia (RD 0.06; 95 % CI [–0.01, 0.13])). Comparing other techniques, no difference was observed between DCE and virtual chromoendoscopy (VCE – including narrow-band imaging [NBI], i-SCAN and flexible spectral imaging color enhancement), in all outcomes except procedure time (mean difference, 6.33 min; 95 % CI, 1.29, 11.33). DCE required a significantly longer procedure time compared with WLE (mean difference, 7.81 min; 95 % CI, 2.76, 12.86). Conclusions We found that dye-spraying chromoendoscopy detected more patients and dysplastic lesions than SD-WLE. Although no difference was observed between DCE and HD-WLE or narrow-band imaging, the main outcomes favored numerically dye-spraying chromoendoscopy, except procedure time. Regarding i-SCAN, FICE and auto-fluorescence imaging, there is still not enough evidence to support or not their recommendation.

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Impact of mucosal inflammation on risk of colorectal neoplasia in patients with ulcerative colitis: a systematic review and meta-analysis

Cited by 72 publications

References 114 publications

The emerging role of histologic disease activity assessment in ulcerative colitis

The emerging role of histologic disease activity assessment in ulcerative colitis

Consecutive negative findings on colonoscopy during surveillance predict a low risk of advanced neoplasia in patients with inflammatory bowel disease with long-standing colitis: results of a 15-year multicentre, multinational cohort study

Surveillance in inflammatory bowel disease: is chromoendoscopy the only way to go? A systematic review and meta-analysis of randomized clinical trials

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