Impact of MTHFR polymorphisms on methylation of MGMT in glioma patients from Northeast China with different folate levels

Liu, N.; Jiang, Jinju; Song, Young Jin; Zhao, Shaodong; Tong, Zhiqiang; Song, Hae-Ri; Wu, Haijian; Jin, Zhu; Gu, Yanqing; Sun, Yan; Hua, Wei; Quan, Jun

doi:10.4238/2013.october.29.10

Cited by 7 publications

(3 citation statements)

References 38 publications

(40 reference statements)

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“… 24 , 25 There are still many controversial results in other cancer types, including prostate cancer, bladder cancer, head and neck cancer, leukemia and lymphoma, nervous system cancers, etc. 26 – 31 …”

Section: Introductionmentioning

confidence: 99%

MTHFR C677T and A1298C polymorphisms and lung cancer risk in a female Chinese population

Tong¹,

Tong²,

Jin³

et al. 2018

CMAR

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ObjectiveTo examine the relationship between polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and susceptibility to lung cancer in a female Chinese population.MethodA hospital-based case-control study of 388 cases and 388 controls was conducted. Two polymorphisms in MTHFR were detected using TaqMan methods.ResultsThe MTHFR C677T polymorphism was associated with the risk of lung cancer and lung adenocarcinoma. Carriers with the TT genotype of C677T were observed to have an increased risk of lung cancer and lung adenocarcinoma (the ORs were 1.550 and 1.588, respectively). By contrast, the A1298C polymorphism had a negative relationship with the risk of lung cancer and lung adenocarcinoma; compared with the AA genotype carriers, the CC genotype carriers had a lower risk of lung cancer and adenocarcinoma in the female Chinese population (ORs were 0.302 and 0.215, respectively). In the stratified analyses, we observed only the A1298C polymorphism in the CC genotype carriers with a statistically significant reduction in the risk of non-small-cell lung cancer, compared to the AA genotype carriers. No significant statistical association was found between the MTHFR gene polymorphisms and risk of the residual subtype of lung cancer.ConclusionThis study provides evidence that the MTHFR C677T polymorphism may contribute to the development of lung cancer and lung adenocarcinoma in a female Chinese population. However, the MTHFR A1298C polymorphism may be associated with the decreasing risk of lung cancer.

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Section: Introductionmentioning

confidence: 99%

MTHFR C677T and A1298C polymorphisms and lung cancer risk in a female Chinese population

Tong¹,

Tong²,

Jin³

et al. 2018

CMAR

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“…SNPs in genes of folate metabolizing enzymes are linked to cancers of various tissue origin like endometrial, cervical, prostate, lung, colon, gastric, breast, head and neck (Boccia et al, 2008;Ericson et al, 2009;Galbiatti et al, 2012;Henao et al, 2005;Izmirli, 2013;Matsuo et al, 2001;Ryan et al, 2001;Xu et al, 2013). SNPs in folate metabolizing enzymes are associated with impaired DNA repair and aberrant patterns of DNA methylation, which are responsible for carcinogenesis (Duthie, 2011;Kim, 1999;Kim et al, 2014;Liu et al, 2013). The SNPs in genes of folate metabolising enzymes like Methylene tetrahydrofolate reductase (MTHFR), 5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase (MTRR) and methionine synthase (MTR) are studied for their increased susceptibility for development of meningioma and glioma (Bethke et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Association of Single Nucleotide Polymorphisms (SNPs) in Genes Encoding for Folate Metabolising Enzymes with Glioma and Meningioma in Indian Population

Kumawat

Gowda

Debnath

et al. 2018

Asian Pac J Cancer Prev

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Background: The association of primary brain tumors with Single Nucleotide polymorphisms (SNPs) in genes of folate metabolising enzymes have been reported to vary among different ethnic population. Here, we have studied the association of SNPs of folate metabolizing genes with the primary brain tumors (glioma and meningioma) in North Indian population. Methods: SNPs of genes coding for folate metabolizing enzymes was carried out in 288 study population from North India [Glioma (n=108), Meningioma (n=76) and healthy-control (n=104)]. The allele-specific polymerase chain reaction (ARMS-PCR) was used to analyse the SNP A1298C of the MTHFR (Methylenetetrahydrofolate-reductase) and the SNP A66G of the methionine synthase reductase (MTRR) genes. The PCR-RLFP (Restriction Fragment Length Polymorphism) was used to analyse the SNP C677T of the Methylene tetrahydrofolate-reductase and the SNP A2756G of the methionine-synthase (MTR) genes. Serum homocysteine, vitamin B 12 and folate levels were evaluated in controls/patients serum using Chemiluminescence immunoassay and the levels were correlated with SNPs genotype. Results: The CC genotype of MTHFR A1298C was observed to have reduced risk of having meningioma than AA genotype (odd ratio=0.62, 95%CI 0.32-0.97, p=0.03). Similarly, the AG genotype of MTRR A66G showed reduced risk of glioma than AA genotype (odd ratio=0.56, 95%CI 0.32-0.97, p=0.039). Furthermore, in patients with AA genotype of MTR A2756G and CT genotype of MTHFR C677T showed higher serum homocysteine level than GG genotype (8.6 µmol/L, p=0.048) and CC genotype (11.2µmol/L, p=0.039) respectively. Conclusion: Our findings provide an insight into the risk association of SNPs in MTHFR A1298C and MTRR A66G genes with glioma/meningioma patients. Further studies are needed to evaluate their clinical implications.

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“…Similarly, concomitant use of alcohol, cigarette and possessing T allele of C677T were significantly higher in OSCC patients[ 21 ]. Besides, the investigators have found homozygotes (TT) of C677T with low levels of folate were significantly associated with decreased methylation of MGMT in Chinese glioma patients[ 40 ]. Low vitamin B2 and low methionine intake were significantly associated with an increased risk of colorectal tumor in individuals with homozygotes (TT) of C677T [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

The association between MTHFR gene polymorphisms (C677T, A1298C) and oral squamous cell carcinoma: A systematic review and meta-analysis

Jiao

Chang

2018

PLoS ONE

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A consensus has not been reached regarding the association of MTHFR gene polymorphism and susceptibility to oral squamous cell carcinoma (OSCC). We performed a meta-analysis to better evaluate the association between MTHFR C677T, A1298C polymorphism and OSCC risk. The studies regarding the association of MTHFR C677T, A1298C polymorphisms and OSCC were identified in PubMed and EMBASE and Google Scholar. The pooled odd rates (ORs) with 95%CIs were estimated using a fixed-effect or random-effect model. The associations between MTHFR polymorphisms and OSCC risk were assessed under the dominant, recessive and additive models. A collective total of 1539 OSCC patients and 2131 normal controls were included across 13 studies. The minor T allele of MTHFR C677T was significantly associated with the increased risk of OSCC development(OR = 1.35, 95%CI 1.04–1.76). Individuals carrying the ‘‘T” allele (TT+CT) had a nearly 43% increased risk for OSCC development when compared with CC (OR = 1.43, 95%CI 1.02–1.99). Under additive model, the results also showed that individuals with CT or TT genotype were more susceptible to OSCC than CC (OR = 1.45, 95%CI 1.02–2.08; OR = 1.79, 95%CI 1.28–2.50; respectively). The subgroup analysis by ethnicity revealed that significant difference in C677T allele distribution could be observed in European (OR = 1.33, 95%CI 1.02–1.75) rather than Asian (OR = 1.59, 95%CI 0.91–2.78). No significant association of MTHFR A1298C polymorphism and OSCC risk could be observed. The present study revealed that T allele and TT genotype of MTHFR C677T polymorphism were significantly associated with the increased risk of OSCC development.

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Impact of MTHFR polymorphisms on methylation of MGMT in glioma patients from Northeast China with different folate levels

Cited by 7 publications

References 38 publications

MTHFR C677T and A1298C polymorphisms and lung cancer risk in a female Chinese population

MTHFR C677T and A1298C polymorphisms and lung cancer risk in a female Chinese population

Association of Single Nucleotide Polymorphisms (SNPs) in Genes Encoding for Folate Metabolising Enzymes with Glioma and Meningioma in Indian Population

The association between MTHFR gene polymorphisms (C677T, A1298C) and oral squamous cell carcinoma: A systematic review and meta-analysis

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