Impact of mindfulness-based stress reduction for people with multiple sclerosis at 8 weeks and 12 months: A randomized clinical trial

Senders, Angela; Hanes, David A.; Bourdette, Dennis; Carson, Kimberly M.; Marshall, Lynn M.; Shinto, Lynne

doi:10.1177/1352458518786650

Cited by 35 publications

(59 citation statements)

References 38 publications

(68 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Twelve RCTs were identified as eligible for inclusion in the systematic review. [21][22][23][24][25][26][27][28][29][30][31][32] However, only eight studies reported endpoint data that could be included in the meta-analysis. 21-24 28-30 32 (figure 1).…”

Section: Resultsmentioning

confidence: 99%

“…Five studies took place in Iran, 23 25-27 29 three in the UK, 22 28 31 two in Italy, 24 32 one each in Switzerland 30 and the USA. 21 Six studies reported assessing a MBI against usual care, 22 23 28-31 in three this was not specified, [22][23][24] while three used an active comparator (psychoeducation control). 21 24 32 Six studies were powered.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…21 Six studies reported assessing a MBI against usual care, 22 23 28-31 in three this was not specified, [22][23][24] while three used an active comparator (psychoeducation control). 21 24 32 Six studies were powered. 21 23 24 29 30 32 Sample sizes ranged from 24 to 150 (median 49).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…21 24 32 Six studies were powered. 21 23 24 29 30 32 Sample sizes ranged from 24 to 150 (median 49). Eight studies measured outcomes at three time points (baseline, post MBI and at follow-up; range 1 month-1 year), 21 22 24 28-32 while four were pre-post measurements only.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Most (at least 447 or 60%) had relapsing-remitting MS, at least 112 (15%) had secondary progressive MS and at least 30 (4%) had primary progressive MS. Mean Expanded Disability Status Scale (EDSS) was reported in five studies, 21 use of disease modifying drugs and/or psychotropic medications 21 22 30 32 (table 2).…”

Section: Participant Characteristicsmentioning

confidence: 99%

See 4 more Smart Citations

Mindfulness-based interventions for mental well-being among people with multiple sclerosis: a systematic review and meta-analysis of randomised controlled trials

Simpson

Ramparsad

et al. 2019

J Neurol Neurosurg Psychiatry

View full text Add to dashboard Cite

Objective impairment of mental well-being (anxiety, depression, stress) is common among people with multiple sclerosis (PwMS). Treatment options are limited, particularly for anxiety. The aim of this study was to update our previous systematic review (2014) and evaluate via meta-analysis the efficacy of mindfulnessbased interventions (MBis) for improving mental wellbeing in PwMS. Methods Systematic searches for eligible randomised controlled trials (RCTs) were carried out in seven major databases (November 2017, July 2018), using medical subject headings and key words. Studies were screened, data extracted, quality appraised and analysed by two independent reviewers, using predefined criteria. Study quality was assessed using the Cochrane Collaboration risk of bias tool. Mental well-being was the primary outcome. Random effects model meta-analysis was performed, with effect size reported as standardised mean difference (SMD). results Twelve RCTs including 744 PwMS were eligible for inclusion in the systematic review, eight had data extractable for meta-analysis; n=635. ethnicity, socioeconomic status, comorbidity and disability were inconsistently reported. MBis varied from manualised to tailored versions, lasting 6-9 weeks, delivered individually and via groups, both in person and online. Overall SMD for mental well-being (eight studies) was 0.40 (0.28-0.53), p<0.01, i 2 =28%; against active comparators only (three studies) SMD was 0.17 (0.01-0.32), p<0.05, i 2 =0%. Only three adverse events were reported. Conclusions MBis are effective at improving mental well-being in PwMS. More research is needed regarding optimal delivery method, cost-effectiveness and comparative-effectiveness. PrOsPErO registration number CRD42018093171.search strategy

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Participant Characteristicsmentioning

confidence: 99%

See 3 more Smart Citations

Mindfulness-based interventions for mental well-being among people with multiple sclerosis: a systematic review and meta-analysis of randomised controlled trials

Simpson

Ramparsad

et al. 2019

J Neurol Neurosurg Psychiatry

View full text Add to dashboard Cite

show abstract

Quality of reporting health behaviors for multiple sclerosis (QuoRH‐MS): A scoping review to inform intervention planning and improve consistency of reporting

Probst,

Kinnane

2024

Brain and Behavior

View full text Add to dashboard Cite

BackgroundMultiple sclerosis (MS) is a neurological condition that necessitates a multidisciplinary approach to aid those living with MS in managing their disease. Health behavior, or lifestyle modification, is an emerging approach to MS self‐management. MS researchers utilize measurement tools to ensure that interventions are best suited to the outcomes, thereby potentially influencing practice. The aim of this study was to investigate which tools are being used for health behavior management studies in people living with MS and develop an aid for tool selection.MethodsA scoping review guided by the PRISMA‐Sc checklist and the JBI manual for evidence synthesis was employed with a systematic search strategy executed across four scientific databases: Medline, PubMed, CINAHL, and Cochrane Libraries. The types of assessment tools used were extracted from the included studies. Each tool was categorized into the health behavior intervention discipline (nutrition, exercise, and psychology) and then subcategorized by the tool's purpose. The frequency of use was determined for each tool. Reporting of validation of the assessment tools were collated to inform a tool selection checklist.ResultsThe review identified a total of 248 tools (12 nutrition, 55 exercise, and 119 psychology unique reports) from 166 studies. Seventy‐seven multidimensional tools were identified including measures of quality of life, fatigue, and functional scales. Only 88 studies (53%) referred to the validity of the tools. The most commonly reported tools were the dietary habits questionnaire (n = 4, nutrition), 6‐minute walk test (n = 17, exercise), Symbol Digits and Modalities Test, and Hospital Anxiety and Depression Scale (n = 15 each, psychology) with the Expanded Disability Status Scale reported 43 times.ConclusionEvidence from interventions may inform practice for health professionals. This review provides insights into the range of tools reported across health behavior intervention studies for MS and offers a guide toward more consistent reporting of study methods.

show abstract

A systematic review and meta-analysis exploring the efficacy of mindfulness-based interventions on quality of life in people with multiple sclerosis

et al. 2022

View full text Add to dashboard Cite

Background Quality of life (QoL) is commonly impaired among people with multiple sclerosis (PwMS). The aim of this study was to evaluate via meta-analysis the efficacy of Mindfulness-based interventions (MBIs) for improving QoL in PwMS. Methods Eligible randomized controlled trials (RCTs) were identified via searching six major electronic databases (MEDLINE, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials, AMED, and PsycINFO) in April 2022. The primary outcome was QoL. Study quality was determined using the Cochrane Collaboration risk of bias tool. Meta-analysis using a random effects model was undertaken. Effect sizes are reported as Standardized Mean Difference (SMD). Prospero ID: 139835. Results From a total of 1312 individual studies, 14 RCTs were eligible for inclusion in the meta-analysis, total participant n = 937. Most studies included PwMS who remained ambulatory. Cognitively impaired PwMS were largely excluded. Comorbidities were inconsistently reported. Most MBIs were delivered face-to face in group format, but five were online. Eight studies (n = 8) measured MS-specific QoL. In meta-analysis, overall effect size (SMD) for any QoL measure (n = 14) was 0.40 (0.18–0.61), p = 0.0003, I2 = 52%. SMD for MS-specific QoL measures (n = 8) was 0.39 (0.21–0.57), p < 0.0001, I2 = 0%. MBI effect was largest on subscale measures of mental QoL (n = 8), SMD 0.70 (0.33–1.06), p = 0.0002, I2 = 63%. Adverse events were infrequently reported. Conclusions MBIs effectively improve QoL in PwMS. The greatest benefits are on mental health-related QoL. However, more research is needed to characterize optimal formatting, mechanisms of action, and effects in PwMS with more diverse social, educational, and clinical backgrounds.

show abstract

Impact of mindfulness-based stress reduction for people with multiple sclerosis at 8 weeks and 12 months: A randomized clinical trial

Abstract: Emotional well-being improved with both MBSR and education. Spontaneous improvement cannot be ruled out as an explanation for findings and additional studies that evaluate the impact of mindfulness training to improve emotional health are warranted.

Cited by 35 publications

References 38 publications

Mindfulness-based interventions for mental well-being among people with multiple sclerosis: a systematic review and meta-analysis of randomised controlled trials

Mindfulness-based interventions for mental well-being among people with multiple sclerosis: a systematic review and meta-analysis of randomised controlled trials

Quality of reporting health behaviors for multiple sclerosis (QuoRH‐MS): A scoping review to inform intervention planning and improve consistency of reporting

A systematic review and meta-analysis exploring the efficacy of mindfulness-based interventions on quality of life in people with multiple sclerosis

Contact Info

Product

Resources

About