Impact of microsampling on toxicological evaluation in rodent safety studies
Kazuaki Takahashi,
Norimichi Hattori,
Hideaki Yokoyama
et al.
Abstract:Recently, animal welfare has been attracting worldwide attention, and implementation of 3Rs (replacement, reduction, and refinement) is prioritized in every way possible in the drug development. Microsampling, in which small amounts of blood are collected, is attracting attention in this context. ICH S3A Q&A focused on microsampling was published in November 2017 to help accelerate the application of microsampling for toxicokinetic assessment. The increased sensitivity of drug measurement apparatuses such … Show more
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