Impact of microbiota on the use and effects of isoflavones in the relief of climacteric symptoms in menopausal women – A review

Monteiro, Naice Eleidiane Santana; Queirós, Lívia Dias de; Lopes, Danielle Branta; Pedro, Adriana Orcesi; Macêdo, Gabriela Alves

doi:10.1016/j.jff.2017.12.043

Cited by 19 publications

(16 citation statements)

References 132 publications

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“…Intestinal wall inoculation with bacteria transforming daidzein into equol using prebiotics or probiotics, the aim being to induce the equol production in the intestine of adults, has not been successful so far [209]. Oral equol administration, on the other hand, has been proven in several studies as a suitable alternative [20].…”

Section: Isoflavone Utilization For Functional Food Productionmentioning

confidence: 99%

Isoflavones

et al. 2019

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Phytoestrogens are naturally occurring nonsteroidal phenolic plant compounds that, due to their molecular structure and size, resemble vertebrate steroids estrogens. This review is focused on plant flavonoids isoflavones, which are ranked among the most estrogenic compounds. The main dietary sources of isoflavones for humans are soybean and soybean products, which contain mainly daidzein and genistein. When they are consumed, they exert estrogenic and/or antiestrogenic effects. Isoflavones are considered chemoprotective and can be used as an alternative therapy for a wide range of hormonal disorders, including several cancer types, namely breast cancer and prostate cancer, cardiovascular diseases, osteoporosis, or menopausal symptoms. On the other hand, isoflavones may also be considered endocrine disruptors with possible negative influences on the state of health in a certain part of the population or on the environment. This review deals with isoflavone classification, structure, and occurrence, with their metabolism, biological, and health effects in humans and animals, and with their utilization and potential risks.

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Section: Isoflavone Utilization For Functional Food Productionmentioning

confidence: 99%

Isoflavones

et al. 2019

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“…Menopausal symptoms are connected to oestrogen deficiency and include vasomotor symptoms (primarily hot flashes), urogenital symptoms, metabolic changes leading to weight gain and higher risk of cardiovascular diseases, and accelerated bone loss leading to osteoporosis [ 19 ]. Dietary supplements containing isoflavones can help to reduce the menopausal symptoms ( Figure 2 ) including frequency of hot flashes in menopausal women [ 20 ], changes in cholesterol forms [ 21 ], and the incidence of subclinical cardiovascular disease [ 22 ].…”

Section: Roles Of Isoflavones In Human Healthmentioning

confidence: 99%

“…Dietary supplements containing isoflavones can help to reduce the menopausal symptoms ( Figure 2 ) including frequency of hot flashes in menopausal women [ 20 ], changes in cholesterol forms [ 21 ], and the incidence of subclinical cardiovascular disease [ 22 ]. However, at least some of the effects were found only in women who were able to metabolize daidzein into equol [ 19 ]. Furthermore, genistein was found to suppress osteoporosis.…”

Section: Roles Of Isoflavones In Human Healthmentioning

confidence: 99%

Production of Bovine Equol-Enriched Milk: A Review

Křížová

Křešťáková

Dadáková

et al. 2021

Animals

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Milk and dairy products are important sources of nutrients in the human diet because they contain a number of essential substances and other biologically active components. Many of these substances can be modified, and thus offer opportunities to use milk and dairy products as functional food. Isoflavones are particularly important in human nutrition due to their diverse pharmacological and antioxidant properties. The clinical effectiveness of isoflavone-rich products is believed to be dependent on their ability to metabolize daidzein to equol, which may directly exert cancer preventive effects. However, only approximately 30–40% of humans are able to produce equol, while animals, in general, produce equol. Equol is the predominant product of bacterial metabolism of isoflavones and can be found in various amounts in some food of animal origin, especially in milk. Therefore, milk and dairy products can be considered to be sources of equol for humans who are not able to produce this metabolite. When the content of isoflavones in milk is to be modified, two groups of factors should be considered, i.e., dietary factors that include the source of isoflavones and the processing effects on feedstuffs and animal factors that include the intake of isoflavones, ruminal and postruminal changes, and the health and physiological status of animals. The approximate content of isoflavones in milk can be predicted using carry-over rates for different dietary sources or using a formula that describes the relationship between equol concentration in milk and formononetin intake. Processing and storage can affect the content and profile of isoflavones in milk and dairy products.

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“…The regular use of soy derivatives has a number of benefits, such as the reduction of serum cholesterol, relief of menopausal symptoms, reduction of cardiovascular diseases, protective effect of carcinogenesis, and antioxidant function (Monteiro, Queirós, Lopes, & Pedro, 2018). On the other hand, phytoestrogens are also recognized as anxiolytic substances and might negatively interfere with endocrine system (Nardi et al, 2017), corroborating the importance of knowing the concentrations of these compounds that people are exposed through the diet.…”

Section: Introductionmentioning

confidence: 99%

Isoflavone quantitation in soymilk: Genistein content and its biological effect

Freddo

Nardi

Bertol

et al. 2019

CyTA - Journal of Food

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Soy derivatives contain isoflavones with structural similarity to estrogen hormones known as phytoestrogens. The levels of isoflavones in these foods are quite variable and often unknown. The objective of this work was to develop and validate a methodology for the quantification of isoflavone genistein in soymilk by liquid chromatography coupled with an ultraviolet detector. After quantifying the levels of genistein in soymilk, the behavioral effects of daily administration of soymilk supplemented or not with glyphosate (50 or 100 mg/kg) throughout the pre-pubertal period in male rats were evaluated. The method developed is selective, sensitive, specific, and precise for the quantification of genistein with a total execution time of 20 min. Behavioral test highlights changes in anxiety pattern after chronic prepubertal exposure to soymilk containing 26.46 μg/mL genistein. Cuantificación de isoflavonas en la leche de soya: el contenido de genisteína y sus efectos biológicos RESUMEN Los derivados de la soya contienen isoflavonas que guardan similitud estructural con las hormonas de estrógeno conocidas como fitoestrógenos. El nivel de isoflavonas en estos alimentos varía bastante y en muchos casos se desconoce. El presente estudio se propuso desarrollar y validar una metodología que permitiera cuantificar la isoflavona genisteína presente en la leche de soya, empleando cromatografía líquida acompañada de un detector ultravioleta. Después de cuantificar el nivel de genisteína en la leche de soya, se evaluaron los efectos que conlleva administrar diariamente leche de soya con y sin suplementos de glifosato (50 mg/kg o 100 mg/kg) en el comportamiento de ratas machos prepúberes. El método desarrollado es selectivo, sensible, específico y preciso para la cuantificación de genisteína, y su tiempo total de ejecución es de 20 minutos. Las pruebas de comportamiento dan cuenta de cambios en los patrones de ansiedad de ratas machos durante el periodo prepubescente como resultado de administrarles leche de soya con un contenido de 26.46 μg/mL de genisteína.

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Impact of microbiota on the use and effects of isoflavones in the relief of climacteric symptoms in menopausal women – A review

Cited by 19 publications

References 132 publications

Isoflavones

Isoflavones

Production of Bovine Equol-Enriched Milk: A Review

Isoflavone quantitation in soymilk: Genistein content and its biological effect

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