Impact of MICA‐TM, MICB‐C1_2_A and C1_4_1 microsatellite polymorphisms on the susceptibility to chronic periodontitis in Germany

Abstract

The major histocompatibility complex class I chain-related gene A (MICA)-TM exon 5 trinucleotide polymorphism, the MICB-C1_2_A intron 1 dinucleotide polymorphism and the tetranucleotide polymorphism C1_4_1 located in the major histocompatibility complex class I region on chromosome 6 were shown to influence various chronic inflammatory conditions. We investigated the association of these microsatellite polymorphisms with chronic periodontitis, a highly prevalent oral inflammatory disease in 389 periodontitis patients and 771 healthy controls with South German genetic background. Genotyping of the MICA-TM, MICB-C1_2_A and C1_4_1 microsatellite polymorphisms was performed by PCR amplification and fragment analysis. Global frequency distribution of MICB-C1_2_A (P = 0.006) and C1_4_1 (P = 0.028) alleles was significantly different between both study groups. Allele-specific analysis revealed that the MICA-TM allele A5 was more prevalent among male periodontitis patients [P = 0.0001; odds ratio (OR) 2.17, 95% confidence interval (CI) 1.55-3.03]. In C1_4_1 allele, three was significantly higher in healthy controls (P = 0.006; OR 0.74, 95% CI 0.60-0.91). Two haplotypes (MICA:A5-C1_4_1:5; P = 0.002; OR 2.63, 95% CI 1.46-4.74 and MICB:CA16-C1_4_1:3; P = 0.014; OR 0.68, 95% CI 0.50-0.92) showed significant differences between periodontitis patients and controls. The MICA-TM, MICB-C1_2_A and C1_4_1 microsatellite polymorphism seem to influence the individual susceptibility to chronic periodontitis in patients with German genetic background.

MIC gene polymorphism and haplotype diversity in Li nationality of Southern China

“…A growing body of research now shows that MICB polymorphism is related to certain diseases . However, as HLA‐MICB‐MICA haplotypes have been reported in different people , this disease association may be secondary and due to LD with HLA alleles. Some reported MICA‐MICB haplotypes were confirmed in our study, for example, MICB*005:02 was in strong LD with MICA*010 , and MICB*008 displayed distinct LD patterns with MICA*002:01 in the Li population.…”

Variants of the human NR1I2 (PXR) locus in chronic periodontitis

“…Selection of study participants was performed on the basis of a standardized periodontal examination procedure, as described previously (17). The diagnosis of periodontitis was made on the basis of the following clinical and radiographic criteria: (i) a total of at least 15 teeth in situ ; (ii) eight or more teeth with a diagnosis of periodontitis clinically defined as a probing pocket depth of ≥ 5 mm and/or attachment loss of ≥ 2 mm at least at one location and/or a furcation involvement of ≥Class II.…”

Major Histocompatibility Complex Class I Chain-Related Gene Polymorphisms: Associated with Susceptibility to Kawasaki Disease and Coronary Artery Aneurysms

“…Some MIC molecules are receptors on NK cells, T4 cells, and T8 cells that mediate host antitumor immune response (Kopp et al, 2009). Recently, Folwaczny et al (2011) demonstrated the association between the MIC SNPs and the susceptibility to chronic periodontitis. Some MIC genetic variation was also associated with ulcerative colitis (Li et al, 2010).…”

“…MICA was found to be associated with Addison's disease (Gambelunghe et al, 1999), Behcet disease (Mizuki et al, 1997), etc. Some MICA polymorphisms have been shown to influence various chronic inflammatory conditions (Folwaczny et al, 2011). Some MIC gene polymorphisms and expressions are associated with autoimmune diseases (Li et al, 2010).…”