Impact of Methionine Synthase Reductase Polymorphisms in Chronic Myeloid Leukemia Patients

Elderdery, Abozer Y.; Tebein, Entesar; Alenazy, Fawaz O.; Elkhalifa, Ahmed M. E.; Shalabi, Manar G.; Abbas, Anass M.; Alhassan, Hassan H.; Davuljigari, Chand B.; Mills, Jeremy

doi:10.3390/genes13101729

Cited by 3 publications

(2 citation statements)

References 38 publications

(45 reference statements)

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“…MTRR is an enzyme responsible for converting methionine synthase into the active status. The most frequent variation of MTRR gene at position 66 causes a substitution of methionine to isoleucine at codon 22 (Elderdery et al., 2022). MTRR rs1801394 (G) allele was known to decrease enzymatic activity leading to higher homocysteine concentration, DNA methylation and thrombotic complications in various diseases (Mahmood et al., 2021).…”

Section: Discussionmentioning

confidence: 99%

The prevalence and linkage disequilibrium of 21 genetic variations related to thrombophilia, folate cycle, and hypertension in reproductive age women of Rostov region (Russia)

Bordaeva,

Derevyanchuk,

Alset

et al. 2023

Annals of Human Genetics

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Several maternal genetic variations are known to play an important role during pregnancy since they can affect mother health and/or fetal growth. The frequency of these variants is variable among different populations. This study aimed to investigate thrombophilia, folate metabolism and hypertension genetic variants in reproductive age women of Rostov region (Russia) and then assess their linkage disequilibrium (LD) and heterogeneity among populations. A total of 3108 reproductive age women were included (33.75 ± 5.13 years). Twenty‐one genetic variants were detected with RT‐PCR. LD was tested according to (D′) coefficient and p value. The highest frequency of mutant allele in studied population was as follows: PAI‐1 rs1799768, MTRR rs1801394, AGT rs699, and AGTR2 rs1403543. We showed a high possibility of coinheritance of MTHFR rs1801133 with rs1801131 and AGT rs699 with rs4762 (D′=0.992 and 0.999, respectively). In addition, comparative analysis showed F7 rs6046, FGB rs1800790, MTR rs1805087, and AGT rs699 significantly more frequent among Rostov females by 1.3–1.5 times than European. MTHFR rs1801133, ADD1 rs4961, AGTR2 rs1403543, NOS3 rs2070744, and rs1799983 were with higher frequencies in Europeans than those in the studied group. Our data could be used as a reference for further associative studies of targeted genetic variations in different pregnancy complications specifically in this population.

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Section: Discussionmentioning

confidence: 99%

The prevalence and linkage disequilibrium of 21 genetic variations related to thrombophilia, folate cycle, and hypertension in reproductive age women of Rostov region (Russia)

Bordaeva,

Derevyanchuk,

Alset

et al. 2023

Annals of Human Genetics

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“…Single nucleotide polymorphisms in various Met metabolic enzymes, including MS A2765G, MTRR A66G, MTHFR 677 or 1,298 gene polymorphism displayed different susceptibility to lymphoma, ALL, AML, and Chronic myeloid leukemia (CML), probably due to subtypes of malignancies, ethic factors, and gender ( 114 – 119 ).…”

Section: Amino Acids In Hematologic Malignanciesmentioning

confidence: 99%

Amino acids in hematologic malignancies: Current status and future perspective

Wang

Zhao

et al. 2023

Front. Nutr.

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In recent years, growing emphasis has been placed on amino acids and their role in hematologic malignancies. Cancer cell metabolism is altered during tumorigenesis and development to meet expanding energetic and biosynthetic demands. Amino acids not only act as energy-supplying substances, but also play a vital role via regulating key signaling pathways, modulating epigenetic factors and remodeling tumor microenvironment. Targeting amino acids may be an effective therapeutic approach to address the current therapeutic challenges. Here, we provide an updated overview of mechanisms by which amino acids facilitate tumor development and therapy resistance. We also summarize novel therapies targeting amino acids, focusing on recent advances in basic research and their potential clinical implications.

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Association of maternal genetic polymorphisms with fetal growth restriction syndrome in Russian pregnant women from Rostov region

Alset,

Butenko,

Pokudina

et al. 2023

Egypt J Med Hum Genet

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Background Fetal growth restriction (FGR) is one of the main syndromes causing fetal morbidity and mortality. It was known to be associated with different factors including maternal, fetal, and environmental. However, the effect of genetic factors in FGR is not totally understood. Recently, researchers have focused on investigating genetic variants as possible markers of FGR. This especially concerns maternal genetic polymorphisms since they could serve as prenatal prognostic biomarkers. Accordingly, we aimed to study the association of several polymorphisms affecting vital processes of pregnancy with FGR in pregnant women. Targeted polymorphisms include methylenetetrahydrofolate reductase (MTHFR) 677C > T; methionine synthase reductase (MTRR) 66A > G; methionine synthase (MTR) 2756A > G; angiotensinogen (AGT) 704 T > C; and vascular endothelial growth factor A (VEGFA) 634C > G. In addition, this study examined SNP–SNP interactions, linkage disequilibrium (LD), and haplotypes association for these polymorphisms in the studied population. Results According to our data, MTRR 66(GG) carriers had increased FGR risk (OR = 3.18, 95% CI 1.31–7.72) while (AG) genotype was associated with lower FGR risk (OR = 0.37, 95% CI 0.17–0.84). AGT 704T > C also showed significant association with FGR with allele (T) as a risk factor. SNP–SNP interactions analysis revealed antagonistic relationship between these two polymorphisms and haplotypes association confirmed this finding. High LD possibility was shown between MTHFR 677C > T and MTR 2756A > G (D′ = 0.999) located on chromosome 1. Conclusion We suggest MTRR 66A > G and AGT 704T > C as associated with FGR susceptibility with antagonistic interaction. Result will help to expand our understanding of FGR as a multifactorial syndrome and improve prenatal prognosis using maternal genetic biomarkers, but further studies in different populations are needed to confirm findings.

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Impact of Methionine Synthase Reductase Polymorphisms in Chronic Myeloid Leukemia Patients

Cited by 3 publications

References 38 publications

The prevalence and linkage disequilibrium of 21 genetic variations related to thrombophilia, folate cycle, and hypertension in reproductive age women of Rostov region (Russia)

The prevalence and linkage disequilibrium of 21 genetic variations related to thrombophilia, folate cycle, and hypertension in reproductive age women of Rostov region (Russia)

Amino acids in hematologic malignancies: Current status and future perspective

Association of maternal genetic polymorphisms with fetal growth restriction syndrome in Russian pregnant women from Rostov region

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