Impact of meteorological conditions on the incidence of acute aortic dissection

Abstract

Background: There is still much controversy about whether meteorological conditions influence the occurrence of acute aortic dissection (AAD). The aim of the present study was to investigate the possible correlation between atmospheric pressure, temperature, lunar cycle and the event of aortic dissection in our patient population. Methods: The clinical data for 348 patients with AAD (73% type Stanford A) were confronted with the meteorological data provided by the Cologne weather station over the same period. Results: There were no statistically significant differences between meteorological parameters on days of AAD events compared with control days. A logistic regression model showed that air pressure (odds ratio [OR] 1.004, 95% confidence interval [CI] 0.991-1.017, p = 0.542), air temperature (OR 0.978, 95% CI 0.949-1.008, p = 0.145), season (p = 0.918) and month of the event (p = 0.175) as well as presence of full moon (OR 1.579, 95% CI 0.763-3.270, p = 0.219) were not able to predict AAD events. Also, no predictive power of meteorological data and season was found on analysing their impact on different types of AAD events. Conclusions: Our study did not reveal any dependence of atmospheric pressure, air temperature or the presence of full moon on the incidence of different types of AAD.

Impact of lunar phase

“…Most recently, Majd et al . have described no association between the lunar cycle and type A dissections in an analysis of 348 patients . Bunevicius et al .…”

A rare case of genetically linked primary distal renal tubular acidosis and Southeast Asian ovalocytosis

“…In the red cell it acts as a component of the membrane cytoskeleton and in both locations acts as a chloride-bicarbonate anion exchanger. 2 This genetic variant results in SAO, but despite its effects on the nephron, does not on its own result in a dRTA phenotype. 2 dRTA is rare, with incidence estimated to be <1:100000.…”

“…2 This genetic variant results in SAO, but despite its effects on the nephron, does not on its own result in a dRTA phenotype. 2 dRTA is rare, with incidence estimated to be <1:100000. 4 It is characterised by the inability of α-intercalated cells of the collecting duct to secrete H + ions into urine and an associated metabolic acidosis caused by a non-functional chloride-bicarbonate anion exchanger in α-intercalated cells.…”

“…SAO is a hereditary haematological condition common in Southeast Asia and Melanesia with a prevalence as high as 30% in some areas. [1][2][3] It presents as macrocytosis with stomatocytes on blood film and may confer some protection against Plasmodium falciparum, but is otherwise clinically benign. 2 Genetically, SAO is an autosomal dominant variant of the SLC4A1/AE1 gene on chromosome 17: a p. Ala400_Ala408 deletion variant (a deletion of codons 400-408 known as B3SAO).…”

“…[1][2][3] It presents as macrocytosis with stomatocytes on blood film and may confer some protection against Plasmodium falciparum, but is otherwise clinically benign. 2 Genetically, SAO is an autosomal dominant variant of the SLC4A1/AE1 gene on chromosome 17: a p. Ala400_Ala408 deletion variant (a deletion of codons 400-408 known as B3SAO). 1 This gene codes for a protein known as 'Band 3' that is found in both the membrane of red blood cells and the basolateral membrane of renal α-intercalated cells in the nephron collecting duct.…”