Impact of Metabolic Syndrome on Severity of COVID-19 Illness

Wu, Shannon S.; Zhou, Keren; Misra‐Hebert, Anita D.; Bena, James; Kashyap, Sangeeta R.

doi:10.1089/met.2021.0102

Cited by 14 publications

(21 citation statements)

References 33 publications

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“…Moreover, the combination of arterial hypertension, obesity and cardiovascular disease has been shown to be the main condition for the development of the metabolic syndrome, which can lead to severe COVID-19 [18][19][20][21][22].…”

Section: Discussionmentioning

confidence: 99%

Clinical and laboratory COVID-19 features in hospitalized patients with concomitant diabetes mellitus type 2: A retrospective study

et al. 2022

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Objective: To investigate the prevalence of diabetes mellitus in comorbidity structures and its effect on the clinical course in hospitalized COVID-19 patients in south region of Kazakhstan. Material and methods: A retrospective analysis of data from 918 patients with COVID-19 treated at the City Clinical Infectious Diseases Hospital was carried out. Pearson's Chi-square test and Student's t-test were conducted. Results: In Kazakhstan, diabetes mellitus occupies the second position in the structure of comorbidities in patients with COVID-19 with a share of 20%. Diabetes mellitus in patients most often occurs in combination with cardiovascular diseases and arterial hypertension (20.3% and 16.3%, respectively). Combination of diabetes mellitus, arterial hypertension and other diseases was detected in 72.4% of patients. Combination of diabetes mellitus, cardiovascular and other diseases was detected in 32.5%. In diabetes mellitus patients, COVID-19 was more severe, the hospital stay was longer, and patients over 60 years of age suffered. These patients had a combination of diabetes mellitus with arterial hypertension, obesity, and cardiovascular diseases. Hyperglycemia, elevated blood pressure, rapid breathing, and low saturation were more common for these patients. Conclusion: Diabetes mellitus ranks second in the structure of comorbidities in COVID-19 in the south region of Kazakhstan and is characterized by a combination with cardiovascular diseases, arterial hypertension and obesity. In patients with diabetes, COVID-19 is more severe, which affects the length of stay in the hospital, the mortality rate and the need for transfer to the Intensive Care Unit.

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Section: Discussionmentioning

confidence: 99%

Clinical and laboratory COVID-19 features in hospitalized patients with concomitant diabetes mellitus type 2: A retrospective study

et al. 2022

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“…Beyond age, sex, and genetic factors, co-morbidities are the main clinical determinants of COVID-19 severity [ 17 , 41 , 42 , 43 ]. Particularly, COVID-19 patients with metabolic syndrome had significantly higher hospitalization and mortality rates [ 44 , 45 ]. Metabolic syndrome is the common denominator of hypertension, diabetes, obesity and dyslipidemia.…”

Section: Factors Modulating Covid-19: Epidemiological and Clinical Datamentioning

confidence: 99%

Factors Modulating COVID-19: A Mechanistic Understanding Based on the Adverse Outcome Pathway Framework

Clerbaux

Albertini

Amigó

et al. 2022

JCM

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Addressing factors modulating COVID-19 is crucial since abundant clinical evidence shows that outcomes are markedly heterogeneous between patients. This requires identifying the factors and understanding how they mechanistically influence COVID-19. Here, we describe how eleven selected factors (age, sex, genetic factors, lipid disorders, heart failure, gut dysbiosis, diet, vitamin D deficiency, air pollution and exposure to chemicals) influence COVID-19 by applying the Adverse Outcome Pathway (AOP), which is well-established in regulatory toxicology. This framework aims to model the sequence of events leading to an adverse health outcome. Several linear AOPs depicting pathways from the binding of the virus to ACE2 up to clinical outcomes observed in COVID-19 have been developed and integrated into a network offering a unique overview of the mechanisms underlying the disease. As SARS-CoV-2 infectibility and ACE2 activity are the major starting points and inflammatory response is central in the development of COVID-19, we evaluated how those eleven intrinsic and extrinsic factors modulate those processes impacting clinical outcomes. Applying this AOP-aligned approach enables the identification of current knowledge gaps orientating for further research and allows to propose biomarkers to identify of high-risk patients. This approach also facilitates expertise synergy from different disciplines to address public health issues.

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“…Recently, the relationship between MetS and the course of infectious diseases caused by some bacteria and viruses has also been studied; however, the exact mechanism of how MetS affects the progression of infectious diseases remains unclear [14] , [15] . Moreover, most studies on the association between MetS and outcomes of COVID-19 have been conducted in patients with severe cases, such as patients who needed hospitalization treatment or intensive care unit (ICU) admission [16] . As COVID-19 has a relatively low mortality rate, studies on the general population, including patients with mild symptoms, are also essential.…”

Section: Introductionmentioning

confidence: 99%

Association between metabolic syndrome and mortality in patients with COVID-19: A nationwide cohort study

Park¹,

Jung²,

Shin³

et al. 2022

Obesity Research & Clinical Practice

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Impact of Metabolic Syndrome on Severity of COVID-19 Illness

Cited by 14 publications

References 33 publications

Clinical and laboratory COVID-19 features in hospitalized patients with concomitant diabetes mellitus type 2: A retrospective study

Clinical and laboratory COVID-19 features in hospitalized patients with concomitant diabetes mellitus type 2: A retrospective study

Factors Modulating COVID-19: A Mechanistic Understanding Based on the Adverse Outcome Pathway Framework

Association between metabolic syndrome and mortality in patients with COVID-19: A nationwide cohort study

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