Impact of mechanical bowel preparation on survival after colonic cancer resection

Collin, Åsa; Jung, B.; Nilsson, Erik; Påhlman, Lars; Folkesson, Joakim

doi:10.1002/bjs.9629

Cited by 18 publications

(5 citation statements)

References 17 publications

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“…However, with the ability to mine large databases electronically, more recent studies have validated the original practice of MBP combined with oral antibiotics, demonstrating a decrease in anastomotic leak and surgical‐site infection rates. The effect of bowel preparation on oncological outcome is largely unknown and there is conflicting evidence regarding the impact of MBP on the long‐term survival of patients with colorectal cancer. Among the many reasons for this conflicting evidence is that the scientific basis of the components of the MBP relative to overall efficacy has not been properly elucidated.…”

Section: Bowel Preparation In the Genomic Eramentioning

confidence: 99%

Gut microbiome influences on anastomotic leak and recurrence rates following colorectal cancer surgery

Gaines

Shao

Hyman

et al. 2018

British Journal of Surgery

125

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Background The pathogenesis of colorectal cancer recurrence after a curative resection remains poorly understood. A yet-to-be accounted for variable is the composition and function of the microbiome adjacent to the tumour and its influence on the margins of resection following resection. Methods PubMed was searched for historical as well as current manuscripts dated between 1970 and 2017 using the following keywords: “colorectal cancer recurrence,” “microbiome,” “anastomotic leak,” “anastomotic failure” and “mechanical bowel preparation”. Results There is a substantial and growing body of literature to demonstrate the various mechanisms by which environmental factors act on the microbiome to alter its composition and function with the net result of adversely affecting oncological outcomes following surgery. Some of these environmental factors include diet, antibiotic use, the methods used to prepare the colon for surgery, and the physiological stress of the operation itself. Conclusion Interrogating the intestinal microbiome using next-generation sequencing technology has the potential to influence cancer outcomes following colonic resection.

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Section: Bowel Preparation In the Genomic Eramentioning

confidence: 99%

Gut microbiome influences on anastomotic leak and recurrence rates following colorectal cancer surgery

Gaines

Shao

Hyman

et al. 2018

British Journal of Surgery

125

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“…However, recent some studies from the United States databases have reported that combining MBP and oral antibiotics results in a significantly lower incidence of AL, incisional SSI and hospital readmission compared with no preoperative bowel preparation in colorectal surgery [6264] . Moreover, regarding the longterm effect of MBP, the 10year cancerspecific survival rate was recently reported to be significantly better in MBP group than in nonMBP group [65,66] . Further studies are required to elucidate the effect of MBP on AL.…”

Section: Mechanical Bowel Preparationmentioning

confidence: 99%

Preoperative, intraoperative and postoperative risk factors for anastomotic leakage after laparoscopic low anterior resection with double stapling technique anastomosis

Kawada

Sakai

2016

WJG

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Anastomotic leakage (AL) is one of the most devastating complications after rectal cancer surgery. The double stapling technique has greatly facilitated intestinal reconstruction especially for anastomosis after low anterior resection (LAR). Risk factor analyses for AL after open LAR have been widely reported. However, a few studies have analyzed the risk factors for AL after laparoscopic LAR. Laparoscopic rectal surgery provides an excellent operative field in a narrow pelvic space, and enables total mesorectal excision surgery and preservation of the autonomic nervous system with greater precision. However, rectal transection using a laparoscopic linear stapler is relatively difficult compared with open surgery because of the width and limited performance of the linear stapler. Moreover, laparoscopic LAR exhibits a different postoperative course compared with open LAR, which suggests that the risk factors for AL after laparoscopic LAR may also differ from those after open LAR. In this review, we will discuss the risk factors for AL after laparoscopic LAR.

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“…More recent studies have added further variables to be considered in this debate. Long‐term results from a randomized control trial in Sweden indicate better survival rates in patients treated with MBP . Analysis of American National Surgical Quality Improvement Program data has shown reduced surgical site infections and anastomotic leak rates in patients treated with a combination of oral antibiotics and MBP .…”

Section: Introductionmentioning

confidence: 99%

A European survey of bowel preparation in colorectal surgery

2017

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Impact of mechanical bowel preparation on survival after colonic cancer resection

Abstract: Patients receiving MBP before elective colonic cancer surgery had significantly better cancer-specific survival after 10 years.

Cited by 18 publications

References 17 publications

Gut microbiome influences on anastomotic leak and recurrence rates following colorectal cancer surgery

Gut microbiome influences on anastomotic leak and recurrence rates following colorectal cancer surgery

Preoperative, intraoperative and postoperative risk factors for anastomotic leakage after laparoscopic low anterior resection with double stapling technique anastomosis

A European survey of bowel preparation in colorectal surgery

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