Impact of mean platelet volume on the occurrence and severity of sudden sensorineural hearing loss

Sağıt, Mustafa; Kavugudurmaz, Mustafa; Güler, Sertaç; Somdas, Mehmet Akıf

doi:10.1017/s002221511300193x

Cited by 26 publications

(23 citation statements)

References 30 publications

(76 reference statements)

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“…Mirvakili et al (2016) in a prospective case-control study showed no association between PC, MPV and PDW and occurrence of SSNHL; only PDW resulted correlated with the severity of hearing loss (p ¼ 0.043). On the contrary, Sagit et al (2013) and Seo et al (2014) analysing, respectively, haematological data of 31 and 348 SSNHL patients evidenced a significant difference in PC values between subjects with and without SSNHL. Furthermore, Yasan et al (2013), Wittig et al (2014), Quaranta et al (2015), Kum et al (2015) did not recognise PC as prognostic factor for hearing recovery (p40.05).…”

Section: Discussionmentioning

confidence: 78%

“…For example, Kanzaki et al (2014) in a retrospective multicentre trial involving 203 SSNHL patients evidenced a negative correlation in hearing recovery rate between high-pitch sloping hearing loss and fibrinogen levels (p ¼ 0.04) and between anacusis and WBC (p ¼ 0.03). Sagit et al (2013) and Mirvakili et al (2016) instead found no association between hearing loss severity and mean platelet volume (MPV) and platelet count (PC), respectively (p40.05).…”

Section: Introductionmentioning

confidence: 98%

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Sudden sensorineural hearing loss: is there a relationship between routine haematological parameters and audiogram shapes?

Salvago

Rizzo

Bianco

et al. 2016

International Journal of Audiology

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Objective: To investigate the relationship between haematological routine parameters and audiogram shapes in patients affected by sudden sensorineural hearing loss (SSNHL). Design: A retrospective study. All patients were divided into four groups according to the audiometric curve and mean values of haematological parameters (haemoglobin, white blood cell, neutrophils and lymphocytes relative count, platelet count, haematocrit, prothrombin time, activated partial thromboplastin time, fibrinogen and neutrophil-to-lymphocite ratio) of each group were statistically compared. The prognostic role of blood profile and coagulation test was also examined. Study sample: A cohort of 183 SSNHL patients without comorbidities. Results: With a 48.78% of complete hearing recovery, individuals affected by upsloping hearing loss presented a better prognosis instead of flat (18.36%), downsloping (19.23%) and anacusis (2.45%) groups (p ¼ 0.0001). The multivariate analysis of complete blood count values revealed lower mean percentage of lymphocytes (p ¼ 0.041) and higher platelet levels (p ¼ 0.015) in case of downsloping hearing loss; with the exception of fibrinogen (p ¼ 0.041), none of the main haematological parameters studied resulted associated with poorer prognosis. Conclusions: Our work suggested a lack of association between haematological parameters and a defined audiometric picture in SSNHL patients; furthermore, only fibrinogen seems to influence the prognosis of this disease.

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Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 98%

Sudden sensorineural hearing loss: is there a relationship between routine haematological parameters and audiogram shapes?

Salvago

Rizzo

Bianco

et al. 2016

International Journal of Audiology

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“…The higher glucose levels observed in our patients (compared with controls) were probably associated with the acute stress caused by patients' sudden hearing loss. Mean platelet volume in patients with sensorineural hearing loss Dear Sirs, We read with interest the article entitled 'Impact of mean platelet volume on the occurrence and severity of sudden sensorineural hearing loss' by Sagit et al 1 In this important study, mean platelet volume, a determinant of platelet activation, was found to be elevated in patients with sudden sensorineural hearing loss. Sudden sensorineural hearing loss is a symptom of cochlear injury.…”

mentioning

confidence: 97%

“…1 These authors investigated whether mean platelet volume was elevated in patients with sudden sensorineural hearing loss (SNHL), compared with healthy controls, and whether it was related to severity of hearing loss. They found that mean platelet volume was significantly greater in the sudden SNHL group compared with the control group.…”

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confidence: 99%

“…In our study, we investigated the relation of mean platelet volume and sudden SNHL, and found elevated mean platelet volume in patients with sudden SNHL, compared with controls. 1 In their letter, Varol and Ozaydin mention that obesity, smoking, coronary artery disease, metabolic syndrome, statin use and atrial fibrillation might have an impact on mean platelet volume. 2,3 However, as stated in the methods section of our paper, patients with coronary artery disease and hypercholesterolaemia were not included in our study.…”

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confidence: 99%

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et al. 2014

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Low‐Normal Platelets and Decreasing Platelets Are Risk Factors for Hearing Impairment Development

Abe

Toyama

Kazurayama³

et al. 2020

The Laryngoscope

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Identification of undefined risk factors will be crucial for the development of therapeutic strategies in hearing impairment. Platelets are likely to affect the development of sudden sensorineural hearing loss, which is a primary risk factor for permanent hearing impairment. This implies that abnormal platelets might contribute to long-term hearing loss. This study investigated the role of platelets in the development of hearing impairment over a 5-year period. Methods: This study was a retrospective cohort study and consisted of a population-based survey, which was performed for 1,897 participants in 2014 to 2019. To evaluate the effect of platelet level on hearing ability, the subjects were divided into two groups: a high-normal platelet group (25 40 × 10 4 cells/μL) and a low-normal platelet group (15 25 × 10 4 cells/μL). Subjects were defined as having hearing impairment when pure tone audiometry was over 25 dB HL in either ear (tested in 2017 and 2019). Incidence of hearing impairment was analyzed. Results: Incidence of hearing impairment at low frequencies was significantly higher in the low-normal platelet group than in the high-normal group year over year. Low-normal platelet count associated with low-frequency hearing impairment (LFHI) incidence (odds ratio [OR], 2.34; 95% confidence interval [CI], 1.15-4.76). In the low-normal platelet group, subjects whose counts declined from baseline developed more LFHI than those whose counts increased over time. Further, decreasing platelets appeared to be an independent risk factor contributing to the incidence of LFHI (OR, 2.10; 95%CI, 1.09-4.06) in the low-normal platelet group. Conclusion: Both a low-normal platelet and a declining platelet count were independently associated with the incidence of LFHI.

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Impact of mean platelet volume on the occurrence and severity of sudden sensorineural hearing loss

Cited by 26 publications

References 30 publications

Sudden sensorineural hearing loss: is there a relationship between routine haematological parameters and audiogram shapes?

Sudden sensorineural hearing loss: is there a relationship between routine haematological parameters and audiogram shapes?

Authors' reply

Low‐Normal Platelets and Decreasing Platelets Are Risk Factors for Hearing Impairment Development

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