Impact of maternal thyroid autoantibodies positivity on the risk of early term birth: Ma’anshan Birth Cohort Study

Yan, Han; Mao, Leijing; Ge, Xing; Huang, Kun; Yan, Shuangqin; Ren, Lingling; Hong, Shikai; Gao, Hui; Sheng, Jie; Xu, Yuanyuan; Pan, Weijun; Zhu, Peng; Hao, Jiahu; Zhu, Dawei

doi:10.1007/s12020-018-1576-6

Cited by 24 publications

(12 citation statements)

References 45 publications

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“…Because rates for moderate and late preterm births were combined, we only have partial data on the specific burden of late preterm birth. Only sparse data exist from lower-and middle-income countries on early term birth rates; Brazil reports 35% [33] and China between 23% and 29% among singleton live births [34]. This lack of information on the burden of early term delivery in lower-and middle-income countries constitutes an important limit to our knowledge.…”

Section: Prevalence Of Late Preterm and Early Term Birthsmentioning

confidence: 99%

Epidemiology of late preterm and early term births – An international perspective

Delnord

Zeitlin

2019

Seminars in Fetal and Neonatal Medicine

114

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Section: Prevalence Of Late Preterm and Early Term Birthsmentioning

confidence: 99%

Epidemiology of late preterm and early term births – An international perspective

Delnord

Zeitlin

2019

Seminars in Fetal and Neonatal Medicine

114

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“…Over the last 30 years, it has become clear that thyroid autoimmunity, including Graves' disease, is correlated with a series of maternal and fetal risks during pregnancy and with female infertility [1][2][3][4][5][6][7][8]. Research has led to different proposals for acting on the target of thyroid autoimmunity.…”

Section: Introductionmentioning

confidence: 99%

Selenium supplementation in the management of thyroid autoimmunity during pregnancy: results of the “SERENA study”, a randomized, double-blind, placebo-controlled trial

et al. 2019

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Purpose Selenium is frequently in nutraceuticals for pregnancy, given its role on fertility and thyroid metabolism. However, most evidence rise from non-controlled studies. We aimed to evaluate the protective effect of selenium against thyroid autoimmunity during and after pregnancy. Methods A multicenter, randomized, double-blind, placebo-controlled trial was performed and promoted by the Young Italian Endocrinologists Group (EnGioI)-Italian Society of Endocrinology. Forty-five women with thyroiditis in pregnancy were enrolled and randomly assigned to L-selenomethionine (L-Se-Met) 83 mcg/day or placebo (PLB) and evaluated at 10 ± 2 (T1), 36 ± 2 weeks of gestation (T2) and 6 months after delivery (postpartum, PP). Results We measured a significant reduction of autoantibodies after pregnancy in L-Se-Met group [at PP: TgAb 19.86 (11.59-52.60), p < 0.01; TPOAb 255.00 (79.00-292.00), p < 0.01], and an antibodies titer's rebound in PLB group (TgAb 151.03 ± 182.9, p < 0.01; TPOAb 441.28 ± 512.18, p < 0.01). A significant increase in selenemia was measured in L-Se-Met group at T2 (91.33 ± 25.49; p < 0.01) and PP (93.55 ± 23.53; p = 0.02). Two miscarriage occurred in PLB. No differences were found in thyroid volume, echogenicity, quality of life, maternal/fetal complications. Conclusions SERENA study demonstrated a beneficial effect of L-Se-Met supplementation on autoantibody titer during pregnancy and on postpartum thyroiditis recurrence.

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“…It was shown that 21% of women of the Whickham cohort coveted to thyroid antibody positivity around the age of menopause [21]. Increased titers were associated with increasing age [22].…”

Section: Resultsmentioning

confidence: 99%

Antithyroid Peroxidase Antibodies and Histopathological Outcomes in Egyptian Patients Subjected to Total Thyroidectomy for Nonmalignant Nodular Goiter

Salman

Rabiee

Salman

et al. 2020

Preprint

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Objective: The study aimed to assess antithyroid antibodies in patients with benign thyroid masses and the effect of total thyroidectomy on the antibodies titers.Patients and Methods: This is a retrospective work of 112 cases managed with total thyroidectomy who have positive antithyroid peroxidase antibodies (TPO-Ab), antithyroglobulin antibodies (Tg-Ab), or both. All patients were euthyroid before surgery. Thyroid function tests and thyroid antibodies levels were measured before and 6 and 12 months after surgery.Results: Histopathological evaluation revealed Hashimoto thyroiditis (47.3%), colloid nodules (22.3%), and lymphocytic thyroiditis (30.4%). All patients were TPO-Ab positive, while 96 patients (85.7%) were Tg-Ab positive before surgery. There was no considerable change in TPO-Ab and Tg-Ab after surgery (p = 0.817, and p=0.560, respectively). Also, there was no significant difference between the three histopathological diagnoses in the levels of TPO-Ab (p = 0.086) or Tg-Ab (p = 0.673). Conclusion: Antithyroid antibodies are not valuable markers for diagnosis or prognosis of benign thyroid diseases subjected to total thyroidectomy. We do not recommend their use beyond being a supportive evidence of the possibility of autoimmune nature of the disease if other criteria are confirmed.

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Impact of maternal thyroid autoantibodies positivity on the risk of early term birth: Ma’anshan Birth Cohort Study

Abstract: Our results show that TPOAb is associated with shorter duration of gestation and with higher risk of premature and early term birth.

Cited by 24 publications

References 45 publications

Epidemiology of late preterm and early term births – An international perspective

Epidemiology of late preterm and early term births – An international perspective

Selenium supplementation in the management of thyroid autoimmunity during pregnancy: results of the “SERENA study”, a randomized, double-blind, placebo-controlled trial

Antithyroid Peroxidase Antibodies and Histopathological Outcomes in Egyptian Patients Subjected to Total Thyroidectomy for Nonmalignant Nodular Goiter

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