Impact of maternal nutrition on breast-milk composition: a systematic review,

Bravi, Francesca; Wiens, Frank; Decarli, Adriano; Pont, Alessia Dal; Agostoni, Carlo; Ferraroni, Monica

doi:10.3945/ajcn.115.120881

Cited by 283 publications

(270 citation statements)

References 51 publications

(235 reference statements)

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“…Other stakeholders have been specifically addressed with targeted communication. Evidence-based recommendations on optimized practice of nutrition before and during pregnancy, during the breast feeding period and the early life of infants, have been developed based on the project results and on systematic reviews of available evidence [35,36,37,38,39,40,41,42], in close collaboration with a broad group of stakeholders (prepared for publication). These recommendations are of considerable importance because most of the current guidance for pregnant women, particularly obese women, and for young children does not take into account the long-term programming consequences of early nutrition.…”

Section: Further Disseminationmentioning

confidence: 99%

Long-Term Health Impact of Early Nutrition: The Power of Programming

Koletzko

Brands²,

Grote³

et al. 2017

Ann Nutr Metab

103

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The Power of Programming conference 2016 at Ludwig-Maximilians-Universität Munich brought together about 600 researchers and other stakeholders from around the world who reviewed the recent evidence on the lasting health impact of environment and nutrition during early life, from pre-pregnancy to early childhood. The conference was hosted by the Early Nutrition Project, a multidisciplinary research collaboration funded by the European Commission with collaborating researchers from 35 institutions in 15 countries in Europe, the United States and Australia. The project explores the early origins of obesity, adiposity and associated non-communicable diseases, underlying mechanisms and opportunities for prevention. The project also proactively supports translational application of research findings. In fact, some existing evidence has already been rapidly adopted into policy, regulatory standards and practice. Further, broad dissemination of findings is achieved through the established digital eLearning platform of the Early Nutrition eAcademy, video clip-based learning and graphically supported messaging to consumers. The project demonstrated powerful effects of early metabolic programming on later health. Compared to other common prevention strategies, modifying risk trajectories in early life can achieve a much larger risk reduction and be more cost-effective. While some effective prevention strategies have been promptly implemented in policy and guidelines, legislation and practice, in other areas, the uptake is limited by a paucity of quality human intervention trials and insufficient evaluation of the feasibility of implementation and econometric impact. This needs to be strengthened by future collaborative research work.

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Section: Further Disseminationmentioning

confidence: 99%

Long-Term Health Impact of Early Nutrition: The Power of Programming

Koletzko

Brands²,

Grote³

et al. 2017

Ann Nutr Metab

103

View full text Add to dashboard Cite

show abstract

“…For instance, no changes have been observed in proteins, and mineral composition (Innis, 2014). However, diet can affect the content of fatty acids and vitamins, such as vitamin B1 and C composition (Bravi et al, 2016). As a consequence it has been suggested that diet can affect the concentrations of gangliosides, such as GM3 and GD3 in human milk (Giuffrida, Elmelegy, Thakkar, Marmet, & Destaillats, 2014).…”

Section: Maternal Factorsmentioning

confidence: 99%

Relationship Between Oligosaccharides and Glycoconjugates Content in Human Milk and the Development of the Gut Barrier

Figueroa-Lozano

Vos

2018

Comp Rev Food Sci Food Safe

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The intestinal immune barrier is considered to be the gatekeeper of the human body and rapidly develops directly after birth. Many pre‐ and postnatal factors influence the development of the gut‐barrier, which is composed of the microbiota, the mucus, the epithelial layer and the mucosal immune system. Even minor disturbances during barrier development can have consequences for health far into adulthood. Here we critically discuss the current knowledge on which pre‐ and postnatal factors influence development, maturation, and maintenance of the gut immune barrier. Human milk has a unique composition and is the gold standard for adequate development of the intestinal immune barrier. Not only the influence of human milk oligosaccharides (HMOs) but also that of glycoproteins (HMGPs) is reviewed. We discuss the influence of maternal genetic factors, such as the secretor and Lewis phenotypes on breast milk fucosylation and sialylation of HMOs and HMGPs. This diversity in HMOs and HMPGs influences microbiota composition and also the development of the immune barrier. Cow milk‐derived infant formula is often being used as an alternative for human breast milk. The consequences of this for proper development of the intestinal immune barrier and, in particular, the differences in the type of oligosaccharides and glycosylation patterns (sialic and fucose composition) between cow and human milk are critically discussed. Current and prospective strategies to promote proper gut‐immune maturation are proposed. These might include more personalized infant formulas when breast milk is not an option.

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“…6 The fat fraction appears to be the most sensible to maternal diet whereas the protein and carbohydrate fraction appear not to be affected. 7 The specific fatty acids in human milk, either synthetized endogenously in the mammary gland or taken up from maternal plasma, reflect changes in the maternal dietary fat within two-three days. Maternal body mass index also contributes to modulate the amount and type of human milk fatty acids; specifically, the amount of saturated fatty acids and the ratio of n-6 to n-3 fatty acids are higher in overweight women's breast milk than in normal weight women's breast milk, also after taking into account maternal diet.…”

Section: Introductionmentioning

confidence: 99%

Human milk: composition and health benefits

2017

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Breastfeeding is widely acknowledged as the normal and unequalled method for feeding infants due to its associated health benefits, both for the infant and the mother. The World Health Organization recommends that infants are exclusively breastfed up to the completion of six months of age, with breastfeeding continuing to be an important part of the diet until the infant is at least two years old. The several health benefits associated with breastfeeding are driven by the combined action of the nutritional and bioactive components in human milk and the magnitude of the majority of the ascertained biological effects is directly dependent on breastfeeding duration. This review briefly summarizes the current knowledge on the composition of human milk and provides an overview on its functional effects on health outcomes, focusing on the latest research results.

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Impact of maternal nutrition on breast-milk composition: a systematic review,

Abstract: The available information on this topic is scarce and diversified. Most of the evidence currently used in clinical practice to make recommendations is limited to studies that only reported indirect associations.

Cited by 283 publications

References 51 publications

Long-Term Health Impact of Early Nutrition: The Power of Programming

Long-Term Health Impact of Early Nutrition: The Power of Programming

Relationship Between Oligosaccharides and Glycoconjugates Content in Human Milk and the Development of the Gut Barrier

Human milk: composition and health benefits

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