Impact of maternal HIV infection on obstetrical and early neonatal outcome

Braddick, M; Kreiss, Joan K.; Embreé, Joanne; Datta, Pratibha; Ndinya-Achola, J. O.; Pamba, H.O.; Maitha, Gregory; Roberts, Pacita L.; Quinn, Thomas C.; Holmes, King K.; Vercauteren, G.; Piot, Peter; Adler, Michael; Plummer, Francis A.

doi:10.1097/00002030-199010000-00009

Cited by 103 publications

(42 citation statements)

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“…HIV exposure during pregnancy has been associated with poor pregnancy outcomes such as preterm birth or LBW compared with nonexposed children [19,[37][38][39][40]. In this study, prevalence of preterm birth was higher in HEU children compared with HIV-unexposed 6 AIDS 2017, Vol 00 No 00 children, though data on gestational age at the time of delivery were only available in one-third of the HEU infants.…”

Section: Discussionmentioning

confidence: 66%

Maternal HIV infection is an important health determinant in non-HIV-infected infants

Rosario

González

Maculuve

et al. 2017

Aids

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Objective: To assess morbidity and mortality in HIV-exposed uninfected (HEU) children to help guiding appropriate clinical care and effective preventive interventions.Design: This is a longitudinal study comparing two cohorts of children; one born to HIV-infected women and the other born to HIV-uninfected women. Methods:We have analyzed prospectively obtained information on nutritional status, morbidity and mortality from 966 HEU and 909 HIV-unexposed infants followed up until their first 18 months of life at a referral health facility in southern Mozambique. Determinants for adverse health outcomes in HEU children were also assessed using multivariate logistic regression.Results: Increased incidence of hospital admissions (P ¼ 0.0015), shorter survival in the first 18 months of life (P ¼ 0.0510) and moderate and severe malnutrition (P ¼ 0.0006 and 0.0014, respectively) were observed among HEU children compared with HIVunexposed children. Incidence of outpatient attendance in HEU children was associated with being men, older age and the mother being on antiretroviral treatment. Among HEU children, those who were never breastfed, or who were weaned or were partially breastfed, had an increased incidence of hospital admissions compared with children who were exclusively breastfed. Conclusion:Maternal HIV infection has important health consequences in non-HIVinfected children. As the prevalence of HIV-infected pregnant women is maintained and the proportion of HIV-infected children declines because of the scale-up of antiretroviral treatment during pregnancy and breastfeeding, more focus should be given to the health needs of HEU children to ensure that the post-2015 sustainable development goals are met.

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Section: Discussionmentioning

confidence: 66%

Maternal HIV infection is an important health determinant in non-HIV-infected infants

Rosario

González

Maculuve

et al. 2017

Aids

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“…Studies from Kenya also showed that HIV-infected women were 3 times more likely to deliver a LBW baby in the presence of HIV-related symptoms and lower CD4 level [33,34]. The Univariate analysis in this study indicated that advanced maternal WHO clinical stage, especially in advanced WHO clinical stage III (p ≤ 0.0001) and stage IV (p ≤ 0.0001) were associated with LBW and PD, even though this variable didn't persist in the multivariate analysis .…”

Section: Discussionmentioning

confidence: 99%

Birth outcome and correlates of low birth weight and preterm delivery among infants born to HIV-infected women in public hospitals of Northwest Ethiopia

Kebede¹,

Andargie²,

Gebeyehu³

2013

Health

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“…Of the 20 studies included in Fisher and colleagues' meta-analysis, 19 were retained for inclusion in the present study (Ao, Sam, Masenga, Seage, & Kapiga, 2006;Ayisi et al, 2000;Braddick et al, 1990;Demissie, Amre, & Tsega, 1996;Fritz et al, 2002;Hargreaves et al, 2002;Kapiga, Lyamuya, Lwihula, & Hunter, 1998;Kapiga et al, 2002;Kapiga et al, 2006;Lewis et al, 2005;Mbulaiteye et al, 2000;Mnyika, Klepp, Kvåle, & Ole-King'ori, 1996;Ndina-Achola et al, 1997;Sebit et al, 2003;Simbayi et al, 2004;Talbot et al, 2002;Tengia-Kessey, Msamanga, & Moshino, 1998;Zablotska et al, 2006;Zuma, Gouws, Williams, & Lurie, 2003) and one (Gilgen, Williams, & Campbell, 2000) was excluded for failing to meet the inclusion criteria specified below (i.e., it was not published in a peer-reviewed journal). An additional eight nonoverlapping studies published prior to 2009 were identified from our previous narrative review (Allen et al, 1992;Bassett et al, 1996;Clift et al, 2003;Dunkle et al, 2004;Fisher, Cook, Sam, & Kapiga, 2008;Msuya et al, 2006;St.…”

Section: Methods Literature Reviewmentioning

confidence: 99%

“…The meta-analysis was re-run excluding these three studies and there was effectively no change in the pooled OR estimate (1.61, 95% CI: 1.38-1.88). Additionally, the cumulative meta-analysis was executed in the absence of several outliers visible in Figure 1 (OR > 3.0) (Allen et al, 1992;Braddick et al, 1990;Fisher et al, 2008;Norris et al, 2009;Seme et al, 2005;Talbot et al, 2000). These studies were not allocated a significant amount of weight and the pooled OR estimate again changed very little (1.54, 95% CI: 1.40-1.70).…”

Section: Sensitivity Analysesmentioning

confidence: 99%

An update on alcohol use and risk of HIV infection in sub-Saharan Africa: Meta-analysis and future research directions

Woolf‐King

Steinmaus

Reingold

et al. 2013

IJADR

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Aims: Sub-Saharan Africa is disproportionately affected by HIV/AIDS, and growing evidence suggests that alcohol consumption is a co-occurring problem in the region. We conducted a meta-analysis on studies of alcohol use and HIV infection in subSaharan Africa in order to assess associations, evaluate heterogeneity in the literature, identify susceptible subgroups, and suggest avenues for future research.Design: We performed a systematic review, including published review articles and electronic database searches, and identified 35 studies on alcohol use and HIV. Setting and participants:All of the studies included in the meta-analysis occurred with adults in sub-Saharan Africa.Measurements: Pooled odds ratio (OR) estimates were calculated using both the fixed inverse variance weighting method and the random effects method when evidence of heterogeneity was present. Findings:The pooled OR estimate for all studies was 1.61 (95% CI: 1.44-1.80). The association between alcohol use and prevalence or incident HIV infection was particularly large among samples who reported problem drinking (OR = 2.17, 95% CI: 1.64-2.87) and drinking in sexual contexts (OR = 1.79, 95% CI: 1.55-2.06). Some evidence of publication bias was present; however, the OR remained statistically significant in small and large studies and with population-based and high-risk samples.

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Impact of maternal HIV infection on obstetrical and early neonatal outcome

Cited by 103 publications

References 0 publications

Maternal HIV infection is an important health determinant in non-HIV-infected infants

Maternal HIV infection is an important health determinant in non-HIV-infected infants

Birth outcome and correlates of low birth weight and preterm delivery among infants born to HIV-infected women in public hospitals of Northwest Ethiopia

An update on alcohol use and risk of HIV infection in sub-Saharan Africa: Meta-analysis and future research directions

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