Impact of Maternal Exercise during Pregnancy on Offspring Chronic Disease Susceptibility

Blaize, A. Nicole; Newcomer, Sean C.

doi:10.1249/jes.0000000000000058

Cited by 54 publications

(44 citation statements)

References 35 publications

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“…31 Table 1 summarizes the recent animal studies, and provides further details on sex differences and variation observed in lean (control) v. obese exercised dams, where appropriate. In pigs, maternal exercise during pregnancy results in enhanced endothelium-dependent vaso-relaxation response in the thoracic aorta of newborn female offspring.…”

Section: Maternal Exercise and Offspring Metabolic Phenotypesmentioning

confidence: 99%

Homage to the ‘H’ in developmental origins of health and disease

Rosenfeld

2016

J Dev Orig Health Dis

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Abundant evidence exists linking maternal and paternal environments from pericopconception through the postnatal period to later risk to offspring diseases. This concept was first articulated by the late Sir David Barker and as such coined the Barker Hypothesis. The term was then mutated to Fetal Origins of Adult Disease and finally broadened to developmental origins of adult health and disease (DOHaD) in recognition that the perinatal environment can shape both health and disease in resulting offspring. Developmental exposure to various factors, including stress, obesity, caloric-rich diets and environmental chemicals can lead to detrimental offspring health outcomes. However, less attention has been paid to date on measures that parents can take to promote the long-term health of their offspring. In essence, have we neglected to consider the ‘H’ in DOHaD? It is the ‘H’ component that should be of primary concern to expecting mothers and fathers and those seeking to have children. While it may not be possible to eliminate exposure to all pernicious factors, prevention/remediation strategies may tip the scale to health rather than disease. By understanding disruptive DOHaD mechanisms, it may also illuminate behavioral modifications that parents can adapt before fertilization and throughout the neonatal period to promote the lifelong health of their male and female offspring. Three possibilities will be explored in the current review: parental exercise, probiotic supplementation and breastfeeding in the case of mothers. The ‘H’ paradigm should be the focus going forward as a healthy start can indeed last a lifetime.

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Section: Maternal Exercise and Offspring Metabolic Phenotypesmentioning

confidence: 99%

Homage to the ‘H’ in developmental origins of health and disease

Rosenfeld

2016

J Dev Orig Health Dis

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“…Regular exercise even in the 3rd trimester neither leads to an increased rate of premature delivery nor to increased hospitalisation [8,10]. Moreover, mostly on the basis of preclinical data, positive effects on the newborn in terms of longterm risk of chronic metabolic, cardiovascular and oncological diseases are discussed [11]. The American College of Obstetricians and Gynecologists (ACOG) therefore now recommends regular, moderate intensity exercise for 30 minutes at least 3 days a week [2].…”

Section: Introductionmentioning

confidence: 99%

Physical Exercise During Pregnancy – How Active Are Pregnant Women in Germany and How Well Informed?

Schmidt

Heilmann

Savelsberg

et al. 2017

Geburtshilfe Frauenheilkd

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ABSTR AC TIntroduction There is sufficient evidence showing the positive effects of physical exercise on various aspects of pregnancy. This study evaluates knowledge and status of physical exercise among pregnant women. MethodsThe standardised paper-pencil questionnaire "Pregnancy Physical Activity Questionnaire" (PPAQ) as well as general demographic questions were used to assess the exercise behaviour of study participants. 83 questionnaires completed by women presenting to the Kiel University Hospital for antenatal assessment were included in the analysis.Results At the time of questionnaire completion 10 women were in the first trimester of pregnancy, 64 in the second, and 9 in the third. Just less than 90 % of participants felt they had been informed "sufficiently" on the topic physical exercise during pregnancy, over 50 % felt they were "well" or "very well" informed. Just less than half of participants received their information from a doctor (either their gynaecologist or general practitioner) and none of these felt "insufficiently" informed. Almost 80 % of participants reported still doing no sport or less exercise than before falling pregnant. The maximum proportional energy expenditure for recreational activity -just under 20 % -was in the third trimester. Women who felt they had been well counselled tended to have higher activity levels.Conclusion Study participants demonstrated a clear decline in physical exercise during pregnancy despite clear evidence of the benefits of regular exercise for pregnant women, and despite participants feeling they were well informed. Detailed information on the recommendations for physical exertion in pregnancy should form an integral part of antenatal counselling. ZUSAMMENFASSUNGEinleitung Die positiven Effekte einer körperlichen Aktivität

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“…It turns out that regular physical activity can bring significant benefits to pregnant women and fetus. Maternal benefits include improving cardiovascular function, lightening weight gain in pregnancy (Melzer et al 2010), mitigating musculoskeletal discomfort, reducing incidence of muscle spasms and lower limb edema, reducing risk of hypertension-related complications (Dempsey et al 2004;Blaize et al 2015). Fetal benefits include reducing fat content, improving stress tolerance and promoting nerve development (Harrod et al 2014;Marques et al 2015).…”

Section: Intervention Of Physical Activity On the Progression Of Gestmentioning

confidence: 99%

Impact of Physical Activity During Pregnancy on Gestational Hypertension

Gao

Ren

Zhou

et al. 2020

Physical Activity and Health

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Background: Hypertensive disorders of pregnancy are characterised by new onset of hypertension after 20 weeks gestation, proteinuria and other associated complications, which are major causes of adverse maternal and neonatal outcome. The benefits of physical activity on reducing the risk of essential hypertension, coronary atherosclerotic heart disease and type 2 diabetes are well documented, but the effcet of physical activity on gestational hypertension is inconclusive. This review presents the state of knowledge related to the impact of physical activity on gestational hypertension. Methods: We searched physical activity and gestational hypertension studies and highlight key articles with a focus on maternal health outcomes to best inform physical activity promotion efforts. Results: Physical activity during pregnancy can reduce the risk of gestational hypertension by improving placental blood flow perfusion deficiency, reducing oxidative stress, improving insulin resistance and improve the prognosis of maternal and fetus. Conclusion: Physical activity is of great benefit to improve the occurrence and development of gestational hypertension. Pregnant women should be guided according to individual factors and complications during pregnancy. However, there have no gold standard about physical activity norms based on gestational hypertension. Scientific computation of big data in real-world clinical research are needed in future research.

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Impact of Maternal Exercise during Pregnancy on Offspring Chronic Disease Susceptibility

Cited by 54 publications

References 35 publications

Homage to the ‘H’ in developmental origins of health and disease

Homage to the ‘H’ in developmental origins of health and disease

Physical Exercise During Pregnancy – How Active Are Pregnant Women in Germany and How Well Informed?

Impact of Physical Activity During Pregnancy on Gestational Hypertension

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