Impact of Maternal Drug Dependency on Birth Weight and Head Circumference of Offspring

Doberczak, Tatiana M.; Thornton, John C.; Bernstein, Jonine L.; Kandall, Stephen R.

doi:10.1001/archpedi.1987.04460110033016

Cited by 25 publications

(19 citation statements)

References 25 publications

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“…This dose-related effect may explain why we did not observe more pronounced neonatal withdrawal in methadone-exposed than in heroinexposed infants (see figure 1): The median initial methadone dose in our detoxification program was 2 -6 times lower than in reported maintenance programs [7].…”

Section: Neonatal Abstinence Syndromementioning

confidence: 55%

“…This may be explained by better nutrition due to diminished drug acquisition related problems [7,18], regular prenatal care [1,11,23], mitigated withdrawal attacks and anabolous effect of methadone [7]. We could not confirm this improvement possibly because our mothers were less socially underprivileged than in other studies (see table III); the higher birth weight in our neonates whose mothers had been completely detoxified, is not due to improved fetal growth, but to longer duration of pregnancy alone.…”

Section: Prenatal Growthmentioning

confidence: 64%

“…Opiate abuse during pregnancy leads to proportional fetal growth retardation [3,8,19,26,28] due to poor maternal nutrition and weight gain during pregnancy [7], additional nicotine abuse [7], infections [19,27], withdrawal followed by fetal asphyxia [25], and opiate effect on fetal growth [6].…”

Section: Prenatal Growthmentioning

confidence: 99%

“…The incidence of successful detoxification was low (< 3%), and an acute dose reduction within the last trimester raised the incidence of preterm deliveries [18]. DOBERCZAK cautions not to reduce methadone dosage during pregnancy because of impaired fetal growth [7]. The aim of our study was to look for differences in prenatal growth and neonatal morbidity between infants of mothers joining a methadone detoxification program during pregnancy and infants of mothers practising uncontrolled opiate abuse.…”

Section: Introductionmentioning

confidence: 97%

“…et des troubles de la croissance foetale[7]. L'objectif de notre etude est d'observer les differences entre les enfants de meres entrees dans notre programme de desintoxication ä la methadone pendant la grossesse et les enfants de meres se droguant de facon incontrollee aux opiaces.…”

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Infrequent neonatal opiate withdrawal following maternal methadone detoxification during pregnancy

U¹,

Kattner²,

Weingart-Jesse³

et al. 1990

Jpme

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The influence of maternal participation in a methadone detoxification program as compared to street drug use on intrauterine growth and neonatal morbidity was analysed in 75 newborns. -58 of 75 pregnant addicts joined the methadone program; in 17 women with successful prepartal detoxification, we found a longer course of pregnancy as well as normalized birth weight, head circumference and respiratory status of the neonates. The HIV-status showed no influence on prenatal growth. 63% of all infants developed a neonatal abstinence syndrome; this incidence was lower after maternal participation in the methadone detoxification program: 55 vs. 88%, p less than 0.05. Postnatal respiratory insufficiency occurred more frequently after methadone exposure than after heroin exposure before birth (p less than 0.05).

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Section: Neonatal Abstinence Syndromementioning

confidence: 55%

Section: Prenatal Growthmentioning

confidence: 64%

Section: Prenatal Growthmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

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Infrequent neonatal opiate withdrawal following maternal methadone detoxification during pregnancy

U¹,

Kattner²,

Weingart-Jesse³

et al. 1990

Jpme

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Chronic Opioid Treatment Arrests Neurodevelopment and Alters Synaptic Activity in Human Midbrain Organoids

Kim,

Xiao,

Chen

et al. 2024

Advanced Science

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Understanding the impact of long‐term opioid exposure on the embryonic brain is critical due to the surging number of pregnant mothers with opioid dependency. However, this has been limited by human brain inaccessibility and cross‐species differences in animal models. Here, a human midbrain model is established that uses hiPSC‐derived midbrain organoids to assess cell‐type‐specific responses to acute and chronic fentanyl treatment and fentanyl withdrawal. Single‐cell mRNA sequencing of 25,510 cells from organoids in different treatment groups reveals that chronic fentanyl treatment arrests neuronal subtype specification during early midbrain development and alters synaptic activity and neuron projection. In contrast, acute fentanyl treatment increases dopamine release but does not significantly alter gene expression related to cell lineage development. These results provide the first examination of the effects of opioid exposure on human midbrain development at the single‐cell level.

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Special population: Pregnancy, pain and addiction

Taylor

2015

Managing Patients With Chronic Pain and Opioid Addiction

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Impact of Maternal Drug Dependency on Birth Weight and Head Circumference of Offspring

Cited by 25 publications

References 25 publications

Infrequent neonatal opiate withdrawal following maternal methadone detoxification during pregnancy

Infrequent neonatal opiate withdrawal following maternal methadone detoxification during pregnancy

Chronic Opioid Treatment Arrests Neurodevelopment and Alters Synaptic Activity in Human Midbrain Organoids

Special population: Pregnancy, pain and addiction

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