Impact of mandibular invasion on prognosis in oral squamous cell carcinoma four centimeters or less in size

Fives, Cassie; Nae, Andreea; Roche, Phoebe; O’Leary, Gerard; Fitzgerald, Brendan; Feeley, Linda; Sheahan, Patrick

doi:10.1002/lary.26211

Cited by 31 publications

(44 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…has encountered the terminology “abuts the mandible” in pathology reports at two separate institutions, which led to the hypothesis of the current study that cases of erosive mandibular invasion were potentially being described as abutting the mandible . The suspicion that cases of erosive mandibular invasion were being missed due to the ambiguity of this terminology was reinforced in the study by Fives et al in Ireland, which reported a series of 31 cases of mandibular invasion by SCC; they found that all 31 cases with mandibular invasion also exhibited medullary space invasion . In the Discussion section of the article by Fives et al, the authors recognized this finding to be abnormal, and described that protocols for sampling bone at their institution were likely prone to missing minor cortical invasion.…”

Section: Discussionmentioning

confidence: 74%

“…Oral cavity SCC has the propensity for mandibular invasion, which results in many diagnostic and therapeutic challenges. The pathophysiology and prognostic implications of mandibular invasion has been a long‐studied topic …”

Section: Introductionmentioning

confidence: 99%

“…has studied the pathologic characteristics of mandibular invasion by SCC at two separate institutions and encountered a frequently utilized terminology at both institutions—the tumor “abuts the mandibular bone”— and these cases were interpreted as not having mandibular invasion . A study by Fives et al reported a series of 31 cases of mandibular invasion by SCC, and found that all 31 cases with mandibular invasion also exhibited medullary space invasion …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Variability in pathologic interpretation of mandibular invasion

2019

View full text Add to dashboard Cite

Objectives/Hypothesis Our objective was to identify the accuracy, sensitivity, and specificity of pathological interpretation of mandibular invasion by oral cavity squamous cell carcinoma (SCC) and compare the sensitivity of detecting mandibular invasion in the erosive versus the infiltrative patterns of invasion. We also aimed to describe the significance of the terminology the carcinoma “abuts the mandible” in pathologic interpretation of mandibular invasion. Study Design Retrospective case series. Methods Mandibulectomy specimens from patients who underwent surgical treatment for oral cavity SCC between January 1, 2005 and December 31, 2015 were retrospectively reviewed by a board‐certified anatomic pathologist. The accuracy of pathologic interpretation of mandibular invasion was calculated using the retrospective interpretation of bone invasion as the true interpretation, which was compared to the interpretation on the original pathology report. Incidence of encountering the terminology the carcinoma “abuts the mandible” in the pathology report was calculated. Results A series of 108 consecutive mandibulectomy specimens were reviewed. Sixty‐nine percent (74/108) of cases were interpreted as having mandibular invasion. The accuracy of interpreting mandibular invasion was 84%. The sensitivities for interpretation of mandibular invasion for the erosive and infiltrative patterns of invasion were 77% (30/39) and 91% (32/35), respectively (P = .08). Nine percent (10/108) of pathology reports utilized the terminology the carcinoma “abuts the mandible,” and 80% (8/10) of these cases exhibited mandibular invasion. Conclusions The accuracy of identifying mandibular invasion is 84%, indicating a certain degree of sampling error and variability in interpretation. A precise pathologic definition of mandibular invasion should be applied during the interpretation of these specimens to minimize variability. Level of Evidence 4 Laryngoscope, 130:1721–1724, 2020

show abstract

Section: Discussionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Variability in pathologic interpretation of mandibular invasion

2019

View full text Add to dashboard Cite

show abstract

“…Tumor size, stage, and bone invasion often considered as severity indicators of OSCC. However, the correlation between bone invasion and OSCC prognosis is still controversial 24,25 . They were using paired biopsy‐confirmed tissue specimens of lesion site from 108 incident and 27 recurrent OSCC patients, the statistical correlation between methylation level and severity of OSCC, reflecting the fact hypermethylation related to the progression of OSCC.…”

Section: Discussionmentioning

confidence: 99%

Hypermethylated PAX1 and ZNF582 genes in the tissue sample are associated with aggressive progression of oral squamous cell carcinoma

Sun

Juan²,

Su³

et al. 2020

J Oral Pathology Medicine

View full text Add to dashboard Cite

Background DNA methylation of paired box gene 1 (PAX1) and zinc finger 582 (ZNF582) is promising cancer biomarkers for oral squamous cell carcinoma detection. This study aims to investigate the correlation between PAX1 or ZNF582 methylation and the progression of oral squamous cell carcinoma (OSCC). Materials and Methods A total of 135 OSCC cases from Peking University School and Hospital of Stomatology were enrolled in this study. Tissue specimens were collected from the lesion site and corresponding adjacent normal site. The methylation level of these two genes was evaluated in primary and recurrent OSCC group. Results Hypermethylation of PAX1 or ZNF582 was observed in lesion sites among primary and recurrent OSCC cases. In the lesion site of primary cases, promoter methylation was observed in T3/T4 (PAX1: P = .02; ZNF582: P = .01), stage III/IV (PAX1: P = .03; ZNF582: P = .01), and bone invasion cases (PAX1: P = .02; ZNF582: P = .047). In the subgroup analysis, the correlation between hypermethylation and OSCC severity remains significant with exposure to smoking/alcohol consumption. Conclusions Hypermethylated PAX1 and ZNF582 can sufficiently act as biomarkers to reflect the severity or progression of OSCC.

show abstract

“…cm(21). A porcentagem significativa de casos com recidiva loco-regional (30,6%), mostra uma dificuldade ainda presente na cura da doença.Com relação à localização do tumor, na amostra estudada a região mais frequente foi o assoalho da cavidade oral, em quase metade dos casos (45%), seguido da área retromolar (16%).…”

unclassified

Estudo das proteínas da transição epitélio-mesênquima na invasão óssea do carcinoma epidermóide da cavidade oral

Vanini¹

View full text Add to dashboard Cite

Vanini J.V. Study of epithelial-mesenchymal proteins in bone invasion of oral squamous cell carcinoma [dissertation]. São Paulo: Universidade de São Paulo, Faculdade de Odontologia; 2019. Original version. Squamous cell carcinoma is the most common cancer of the oral cavity. When the tumor invades the bone tissue, the prognostic and survival rate decreases a lot, and the treatment becomes more aggressive, with several damages to the patient and health system. Many of the molecular mechanisms of this process are not understood yet, but it's already known that one of central processes of tumor evolution -adjacent tissues invasion and metastasis -is a large spectrum of phenotypic changes in epithelial cells to mesenchymal, in a process named as epithelial-mesenchymal transition. During this phenomenon, there are a lot of changes in the cells protein expression, which can be used as biomarkers for diagnostic and determination of tumor aggressiveness in early stages, as also the possibility of developing new treatment drugs, more specific and efficient. The objective of this retrospective study is to evaluate if epithelial-mesenchymal transition is present in bone invasion of oral squamous cell carcinoma, by immunohistochemistry evaluation of E-cadherin, Twist, Vimentin, TGFβ1 and Periostin expression. The proteins expression was very heterogeneous. E-cadherinand Twist showed high levels of positivity, and were found associations between Twist positive expression and infiltrative bone invasion pattern (p=0,041), primary tumor site close to bone (p=0,014) and Periostin negative expression (p=0,031), suggesting this transcription factor could be strongly involved in the disease evolution in bone tissue. There are also associations between Vimentin expression and tumor size. The results of this study suggests that epithelial-mesenchymal transition could be present in some level of its spectrum in bone invasion of oral squamous cell carcinoma.

show abstract

Impact of mandibular invasion on prognosis in oral squamous cell carcinoma four centimeters or less in size

Abstract: 4. Laryngoscope, 127:849-854, 2017.

Cited by 31 publications

References 14 publications

Variability in pathologic interpretation of mandibular invasion

Variability in pathologic interpretation of mandibular invasion

Hypermethylated PAX1 and ZNF582 genes in the tissue sample are associated with aggressive progression of oral squamous cell carcinoma

Estudo das proteínas da transição epitélio-mesênquima na invasão óssea do carcinoma epidermóide da cavidade oral

Contact Info

Product

Resources

About