Impact of Malnutrition on Prognosis and Coronary Artery Calcification in Patients with Stable Coronary Artery Disease

Anzaki, Kazuhiro; Kanda, Daisuke; Ikeda, Yoshiyuki; Takumi, Takuro; Tokushige, Akihiro; Ohmure, Kenta; Sonoda, Takeshi; Arikawa, Ryo; Ohishi, Mitsuru

doi:10.1016/j.cpcardiol.2022.101185

Cited by 9 publications

(5 citation statements)

References 31 publications

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“…GNRI has also been reported to predict cardiovascular events, including cardiovascular disease mortality, in patients with heart failure ( 37 ). Furthermore, a study by Anzaki et al ( 38 ) showed that low GNRI levels were associated with all-cause mortality and major adverse cardiovascular events after elective percutaneous coronary intervention (PCI). Cheng et al ( 11 ) shown that in patients with chronic coronary artery occlusion (CTO) following PCI, the GNRI score at admission was a reliable predictor of adverse cardiovascular events.…”

Section: Discussionmentioning

confidence: 99%

Association between the geriatric nutritional risk index and the risk of stroke in elderly patients with hypertension: A longitudinal and cohort study

Cai

Wen

et al. 2022

Front. Nutr.

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ObjectiveWe aimed to investigate the association between the GNRI and the risk of stroke in elderly patients with hypertension.MethodsA total of 5312 elderly hypertensive patients free of history of stroke were included. Multivariate Cox models were used to calculate hazard ratios (HRs) and their 95% confidence intervals (CIs) for stroke and its subtypes.ResultsThe average time of follow-up was 3.8 years, and the median time was 3.2 years. We identified 640 individuals with stroke, of whom 526 had an ischemic stroke (IS) and 114 had a hemorrhagic stroke (HS). After adjusting for confounding variables, compared with participants in the lowest quartile of the GNRI, those in the third and fourth quartiles were associated with a decreased risk of stroke (adjusted HR 0.72, 95% CI 0.58–0.90, and adjusted HR 0.58, 95% CI 0.46–0.74, respectively, P for trend < 0.001). Similar results were found for IS and HS. Moreover, there were L-shaped associations of GNRI with new-onset HS (P for non-linearity = 0.034). Multiple sensitivity analyses and stratified analyses did not materially change the results.ConclusionsIn summary, we found that a lower GNRI was associated with a higher risk of incident stroke in elderly hypertensive patients. Additional prospective data collection is required to confirm our findings.

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Section: Discussionmentioning

confidence: 99%

Association between the geriatric nutritional risk index and the risk of stroke in elderly patients with hypertension: A longitudinal and cohort study

Cai

Wen

et al. 2022

Front. Nutr.

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“…The parameters of GNRI include height, weight, and albumin, and are also improved by NRI recommended by PNNs. It has been proved to have a good predictive ability for the prognosis of a variety of diseases, such as coronary heart disease patients undergoing percutaneous coronary intervention, 32 patients after hip fracture surgery, 33 patients with diabetic foot ulcers, 34 and patients after radical oncological surgery. 35 Our results showed that GNRI had a good predictive ability for the risk of death in patients with active pulmonary TB, and its predictive value tended to be higher than BMI, which also suggested that in addition to focusing on weight change during treatment, albumin supplementation should not be ignored.…”

Section: Discussionmentioning

confidence: 99%

Malnutrition is Associated with an Increased Risk of Death in Hospitalized Patients with Active Pulmonary Tuberculosis: A Propensity Score Matched Retrospective Cohort Study

Xu¹,

Zhu²,

Cai³

et al. 2022

IDR

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Background This study aimed to investigate whether nutrition levels in patients with active pulmonary tuberculosis (TB) affect their risk of all-cause mortality during hospitalization and to further evaluate the predictive ability of Geriatric Nutritional Risk Index (GNRI) and Body Mass Index (BMI) for risk of all-cause mortality. Methods Patients from January 1, 2020 to December 31, 2021 were retrieved, and a total of 1847 were included. The primary outcome was all-cause mortality. Propensity score matching (PSM) was performed for risk adjustment, and receiver operating characteristic (ROC) curve analysis was performed to assess the predictive ability of GNRI and BMI for all-cause mortality. Results Malnourished TB patients were older, had more congestive heart failure, and had more chronic obstructive pulmonary disease or asthma. Under the nutrition level grouping defined by GNRI, the all-cause mortality in the malnourished group did not appear to reach a statistical difference compared with the nonmalnourished group (P = 0.078). When grouped by level of nutrition as defined by BMI, the all-cause mortality was higher in the malnourished group (P = 0.009), and multivariate logistic regression analysis revealed that malnutrition was an independent risk factor for all-cause mortality. After propensity score matching, the results showed that the all-cause mortality was higher in the malnutrition group, regardless of BMI or GNRI defined nutrition level grouping, compared with the control group (both P < 0.001). The ROC curve analysis revealed that the area under the curve (AUC) was 0.811 ([95% confidence interval (CI) 0.701–0.922], P < 0.001) for GNRI and 0.728 ([95% CI 0.588–0.869], P = 0.001) for BMI. Conclusion In the clinical treatment of patients with active TB, more attention should be paid to the management of nutritional risk. GNRI may be a highly effective and easy method for predicting short-term outcomes in patients with active pulmonary TB.

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“…Recently, the side effects of malnutrition in cardiovascular diseases have come under the researchers' spotlight. Clinical studies have demonstrated that malnutritional status has negative effects on people affected by cardiovascular diseases including ACS (13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Geriatric nutritional risk index predicts all-cause mortality in the oldest-old patients with acute coronary syndrome: A 10-year cohort study

Liu

Shen²,

Hou³

et al. 2023

Front. Nutr.

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Background and objectiveNutritional status assessment in acute coronary syndrome (ACS) patients has been neglected for a long time. The geriatric nutritional risk index (GNRI) is a sensitive indicator for assessing the nutritional status of the elderly. This study aims to explore the association between GNRI and all-cause mortality in the oldest-old patients with ACS.MethodsThe patients who met the inclusion criteria were consecutively enrolled from January 2006 to December 2012. Clinical data were collected on admission, and all subjects were followed after being discharged. The nutritional status was evaluated using GNRI. The relationship between GNRI and all-cause mortality was assessed by using different analyses.ResultsA total of 662 patients with a mean age of 81.87 ± 2.14 years old were included in our study, and followed (median: 63 months, IQR 51–71). Patients whose GNRI ≤ 98 were reported as at risk of malnutrition (31.11%, n = 206). In multivariable analysis, we found that for each SD increase in GNRI, the risk of all-cause mortality lowered by 23%, and the HR for GNRI ≤ 98 was 1.39 (95% CI 1.04–1.86). After stratifying patients into three groups by tertiles of GNRI, we found that the HRs for tertile 2 and tertile 3 were 1.49 (95% CI 1.02–2.19) and 1.74 (95% CI 1.22–2.50), respectively. The trend test revealed a dose–response relationship between GNRI and all-cause mortality in the oldest-old with ACS. Lastly, in subgroup analyses, we found a reliable association between GNRI and all-cause mortality.ConclusionMalnutrition is common in the oldest-old patients with ACS, and GNRI could predict their long-term all-cause mortality in a dose-dependent manner. GNRI may be a prospective index for risk-stratification and secondary-prevention in the oldest-old patients with ACS.

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Impact of Malnutrition on Prognosis and Coronary Artery Calcification in Patients with Stable Coronary Artery Disease

Cited by 9 publications

References 31 publications

Association between the geriatric nutritional risk index and the risk of stroke in elderly patients with hypertension: A longitudinal and cohort study

Association between the geriatric nutritional risk index and the risk of stroke in elderly patients with hypertension: A longitudinal and cohort study

Malnutrition is Associated with an Increased Risk of Death in Hospitalized Patients with Active Pulmonary Tuberculosis: A Propensity Score Matched Retrospective Cohort Study

Geriatric nutritional risk index predicts all-cause mortality in the oldest-old patients with acute coronary syndrome: A 10-year cohort study

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