2013
DOI: 10.1186/1475-2875-12-139
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Impact of malaria during pregnancy on pregnancy outcomes in a Ugandan prospectivecohort with intensive malaria screening and prompt treatment

Abstract: BackgroundMalaria in pregnancy (MiP) is a major public health problem in endemic areas of sub-Saharan Africa and has important consequences on birth outcome. Because MiP is a complex phenomenon and malaria epidemiology is rapidly changing, additional evidence is still required to understand how best to control malaria. This study followed a prospective cohort of pregnant women who had access to intensive malaria screening and prompt treatment to identify factors associated with increased risk of MiP and to ana… Show more

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Cited by 127 publications
(142 citation statements)
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“…Different species of malaria parasite release different antigen to facilitate binding. For instance, P. falciparum releases Erythrocyte Binding Antigen-175 (EBA-175) [51], a microneme protein which binds to the sialic acid residue on glycophorins of the RBCs [55]. A merozoite serine protease cleaves band 3, causing a disruption in the cytoskeleton of RBC.…”
Section: Malaria Induced Anemia (Mia) In Pregnancymentioning
confidence: 99%
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“…Different species of malaria parasite release different antigen to facilitate binding. For instance, P. falciparum releases Erythrocyte Binding Antigen-175 (EBA-175) [51], a microneme protein which binds to the sialic acid residue on glycophorins of the RBCs [55]. A merozoite serine protease cleaves band 3, causing a disruption in the cytoskeleton of RBC.…”
Section: Malaria Induced Anemia (Mia) In Pregnancymentioning
confidence: 99%
“…This results in mechanical destruction of the RBC through haemolysis [51]. The AMA-1 also releases coats the surface of non-parasitized RBCs and are cleared by the immune system [55,51]. Again, the antigens act to down regulate erythropoiesis, and the cumulative effect of these activities seeks to reduce the quantity of RBCs leading to anaemia [48].…”
Section: Malaria Induced Anemia (Mia) In Pregnancymentioning
confidence: 99%
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“…Many studies from areas with different malaria transmission patterns have investigated the consequences of malaria in pregnancy on both maternal health and birth outcomes (DeBeaudrap et al, 2013). Malaria in pregnancy has been associated with significant degree of intrauterine growth restriction, 36% of preterm deliveries, 30% of preventable low birth weight deliveries, 14% of low birth weight deliveries and 15% of maternal anaemia (Steketee et al, 2001).…”
Section: Introductionmentioning
confidence: 99%
“…Malaria infection during pregnancy has been a major public health problem in endemic areas such as tropical and subtropical regions throughout the world. 4 The burden of malaria infection during pregnancy is caused chiefly by Plasmodium falciparum; the most common malaria species in Africa. 5 Primigravida accounted for a greater part of the 60% prevalence of malaria that affected mainly women in their first trimester of pregnancy, and the age range of the infected women is 30-39 years.…”
Section: Introductionmentioning
confidence: 99%