Impact of main bronchial lymph node involvement in pathological T1-2N1M0 non-small-cell lung cancer: multi-institutional survey by the Japan National Hospital Study Group for Lung Cancer

Abstract

Involvement of the main bronchial lymph nodes is a significant factor to predict a worse prognosis in pathological T1-2N1M0 patients with NSCLC.

Prognostic value of different N1 lymph node zones in pN1M0 non-small cell lung cancer: a systematic review and meta-analysis

“…Two other studies used patient information from the same database, so we excluded a study with fewer patients. Finally, a total of 10 studies 6 , 13 – 21 were identified in the meta-analysis. The PRISMA statement of the selection flow diagram is shown in Fig.…”

Quantification of regional lymph node involvement in lung cancer

“…Thus, for pathologically staged I tumours, the number of removed lymph nodes at thoracotomy seems to have prognostic impact, although the cut-off varies in different studies from six to more than 15 removed lymph nodes 2 3. Within the N1 category, involvement of hilar (main bronchi) lymph nodes has been consistently associated with worse prognosis compared with involvement of intrapulmonary lymph nodes 4 5. Other indicators of worse prognosis in N1 disease are macroscopic nodal involvement and multiple nodal involvement,6 involvement of multiple nodal stations,7 and metastatic involvement—as opposed to direct nodal invasion, at least, in squamous cell carcinomas 8.…”