Impact of lympho‐vascular space invasion on tumor characteristics and survival outcome of women with low‐grade serous ovarian carcinoma

Matsuo, Koji; Wong, Kwong-Kwok; Fotopoulou, Christina; Blake, Erin A.; Robertson, Sharon E.; Pejović, Tanja; Frimer, Marina; Pardeshi, Vishakha; Hu, Wei; Choi, Jong Hoon; Sun, Charlotte C.; Richmond, Abby M.; Marcus, Jenna; Hilliard, Maren A.M.; Mostofizadeh, Sayedamin; Mhawech‐Fauceglia, Paulette; Abdulfatah, Eman; Post, Miriam D.; Saglam, Ozlen; Shahzad, Mian M.K.; Karabakhtsian, Rouzan G.; Ali-Fehmi, Rouba; Gabra, Hani; Roman, Lynda D.; Sood, Anil K.; Gershenson, David M.

doi:10.1002/jso.24801

Cited by 11 publications

(16 citation statements)

References 45 publications

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“…This finding was also reported by Chen et al in 2015, 25 then again in in a population of LGSOC patients only. 19 Presence of LVSI was correlated with decreased RFS (HR = 1.57; 95% CI, 1.06-2.34; p = .026) but not OS in multivariate analysis. The present study corroborates these findings (HR = 2.25 [95% CI, 1.12-4.5], p = .022 for RFS and p = .056 for OS).…”

Section: Discussionmentioning

confidence: 90%

“…In is optimal or suboptimal rather than complete. [17][18][19] Grabowski et al 6 showed that the impact of surgery is even more tangible in LGSOC than in HGSOC. In their study, patients with low-grade tumors had better prognoses than those with high-grade tumors when all visible disease was removed, but both had similar survival outcomes when it was not, even with adjuvant therapy.…”

Section: Discussionmentioning

confidence: 99%

“…The high rate of complete cytoreduction in our cohort seems to improve survival outcomes when compared to other groups as rates of complete debulking ranged from 16.7% to 51.7% in the literature. [17][18][19][20][21] | 1805…”

Section: Discussionmentioning

confidence: 99%

“…Both studies had robust designs but included all histological subtypes of EOC in their analysis and had very few cases of LGSOC (n = 1 and n = 22, respectively). Matsuo et al 19 studied LVSI exclusively in the setting of…”

Section: Discussionmentioning

confidence: 99%

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Impact of cytoreductive surgery on survival of patients with low‐grade serous ovarian carcinoma: A multicentric study of Turkish Society of Gynecologic Oncology (TRSGO‐OvCa‐001)

Vatansever

Taşkiran

Meydanlı

et al. 2021

Journal of Surgical Oncology

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Background and Objectives: The aim of this study was to analyze the factors affecting recurrence-free (RFS) and overall survival (OS) rates of women diagnosed with low-grade serous ovarian cancer (LGSOC).Methods: Databases from 13 participating centers in Turkey were searched retrospectively for women who had been treated for stage I-IV LGSOC between 1997 and 2018.Results: Overall 191 eligible women were included. The median age at diagnosis was 49 years (range, 21-84 years). One hundred seventy-five (92%) patients underwent primary cytoreductive surgery. Complete and optimal cytoreduction was achieved in 148 (77.5%) and 33 (17.3%) patients, respectively. The median follow-up period was 44 months

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Impact of cytoreductive surgery on survival of patients with low‐grade serous ovarian carcinoma: A multicentric study of Turkish Society of Gynecologic Oncology (TRSGO‐OvCa‐001)

Vatansever

Taşkiran

Meydanlı

et al. 2021

Journal of Surgical Oncology

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“…LGSC are rare ovarian cancer type that seems to originate from low-malignant potential serous ovarian tumors or de novo from ovarian or peritoneal surfaces [3456]. Accumulating data underlined that LGSC are characterized by partial chemoresistance [3-6].…”

Section: Introductionmentioning

confidence: 99%

The detrimental effect of adopting interval debulking surgery in advanced stage low-grade serous ovarian cancer

et al. 2019

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ObjectiveTo examine outcomes of patients having treatments for newly diagnosed advanced stage low-grade serous ovarian cancer (LGSC).MethodsWe conducted a retrospective case series of women affected by advanced stage (stage IIIB or more) LGSC undergoing surgery in a single oncologic center between January 2000 and December 2017. Survival outcomes were assessed using Kaplan-Meier and Cox models.ResultsData of 72 patients were retrieved. Primary cytoreductive surgery was attempted in 68 (94.4%) patients: 19 (27.9%) had residual disease (RD) >1 cm after primary surgery. Interval debulking surgery (IDS) was attempted in 15 of these 19 (78.9%) patients and the remaining 4 patients having not primary debulking surgery. Twelve out of 19 (63.1%) patients having IDS had RD. After a mean (±standard deviation) follow-up was 61.6 (±37.2) months, 50 (69.4%) and 22 (30.5%) patients recurred and died of disease, respectively. Via multivariate analysis, non-optimal cytoreduction (hazard ratio [HR]=2.79; 95% confidence interval [CI]=1.16–6.70; p=0.021) and International Federation of Obstetrics and Gynecologists (FIGO) stage IV (HR=3.15; 95% CI=1.29–7.66; p=0.011) were associated with worse disease-free survival. Via multivariate analysis, absence of significant comorbidities (HR=0.56; 95% CI=0.29–1.10; p=0.093) and primary instead of IDS (HR=2.95; 95% CI=1.12–7.74; p=0.027) were independently associated with an improved overall survival.ConclusionLGSC is at high risk of early recurrence. However, owing to the indolent nature of the disease, the majority of patients are long-term survivors. Further prospective studies and innovative treatment modalities are warranted to improve patients care.

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Factors associated with the involvement of lymph nodes in low‐grade serous ovarian cancer

Durmuş

Meydanlı

Akıllı

et al. 2021

Journal of Surgical Oncology

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Background and Objectives: Evaluating nodal metastases in low-grade serous ovarian cancer (LGSOC) patients.Methods: Women with LGSOC who had undergone primary cytoreductive surgery comprising systematic pelvic-paraaortic lymphadenectomy were included. Data were obtained retrospectively from 12 oncology centers.Results: One hundred and forty-eight women with LGSOC who had undergone comprehensive surgical staging were included. Seventy-one (48.0%) patients had metastatic lymph nodes. Preoperative serum CA-125 levels of ≥170 U/ml (odds ratio [OR]: 3.84; 95% confidence interval [CI]: 1.22-12.07; p = 0.021) and presence of lymphovascular space invasion (LVSI) (OR: 13.72; 95% CI: 3.36-55.93; p < 0.001) were independent predictors of nodal metastasis in LGSOC. Sixty (40.5%) patients were classified to have apparently limited disease to the ovary/ovaries. Twenty (33.3%) of them were upstaged after surgical staging. Twelve (20.0%) had metastatic lymph nodes.

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Impact of lympho‐vascular space invasion on tumor characteristics and survival outcome of women with low‐grade serous ovarian carcinoma

Abstract: LVSI in the ovarian tumor is associated with adverse clinico-pathological characteristics and decreased progression-free survival in women with low-grade serous ovarian carcinoma.

Cited by 11 publications

References 45 publications

Impact of cytoreductive surgery on survival of patients with low‐grade serous ovarian carcinoma: A multicentric study of Turkish Society of Gynecologic Oncology (TRSGO‐OvCa‐001)

Impact of cytoreductive surgery on survival of patients with low‐grade serous ovarian carcinoma: A multicentric study of Turkish Society of Gynecologic Oncology (TRSGO‐OvCa‐001)

The detrimental effect of adopting interval debulking surgery in advanced stage low-grade serous ovarian cancer

Factors associated with the involvement of lymph nodes in low‐grade serous ovarian cancer

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