Impact of low-level laser therapy on the quality of life of patients with xerostomia undergoing head and neck radiotherapy: a systematic review

Ribeiro, Lucas Nascimento; de Vasconcelos Carvalho, Marianne; de Oliveira Limirio, João Pedro Justino; do Egito Vasconcelos, Belmiro Cavalcanti; Moraes, Sandra Lúcia Dantas; Pellizzer, Eduardo Piza

doi:10.1007/s00520-024-08325-5

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…LLLT can minimize radiation-induced hyposalivation and presents promising results in xerostomia, consequently improving the QoL of patients undergoing RT in the head and neck region [23,24]. In view of the above, it is extremely important to conduct studies that evaluate the effectiveness of LLLT treatment in preventing hyposalivation, as it is a complex condition that has demonstrated negative effects on the QoL of individuals who need to undergo such treatment.…”

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confidence: 99%

Extraoral photobiomodulation to prevent hyposalivation in patients treated with head and neck radiotherapy: randomized double-blind clinical trial

de Albuquerque,

Ribeiro,

Carvalho

et al. 2024

Preprint

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Purpose To evaluate the efficacy of extraoral photobiomodulation in preventing hyposalivation in patients treated with radiotherapy for head and neck cancers. Methods 52 patients divided into an intervention group (23 patients) and a control group (29 patients). The parameters used were: 30mW, 7.5 J / cm2, 10s / point, 0.3 J / point, a wavelength of 830 nm and an area of 0.028 cm². The salivary flow at rest and the xerostomia inventory were evaluated three times from the beginning to the end of radiotherapy and one month after the end. The primary outcome was the absence of hyposalivation, with secondary outcomes showing a higher prevalence of dry mouth and hyposalivation. Results Most of the sample remained with salivary flow > 0.2 ml / min before and after radiotherapy (control 69% × 65% intervention p > 0.05). The prevalence of xerostomia was higher in the control group (21% x 17% p > 0.05) as well as the complaint of severe xerostomia at the end of radiotherapy (35% x 30% p > 0.05). Oral pain was the most frequent complication (26% vs. 20%, P > 0.05). Conclusion Extraoral photobiomodulation was not effective in preventing the reduction of salivary flow during radiotherapy, but it was responsible for higher flow values compared to the control group. This study allowed for a lower prevalence and severity of xerostomia; however, further studies should be conducted to confirm the real benefits. Trial Registration Numbe at REBEC: RBR5746z9, Dated: April 5th 2020

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Section: Introductionmentioning

confidence: 99%

Extraoral photobiomodulation to prevent hyposalivation in patients treated with head and neck radiotherapy: randomized double-blind clinical trial

de Albuquerque,

Ribeiro,

Carvalho

et al. 2024

Preprint

Self Cite

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Xerostomia: Current Advancements and Insights in Biomedical and Biotechnology Research

Kalgeri,

Doddawad,

Shivakumar

et al. 2024

Biomedical and Biotechnology Research Journal

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Xerostomia, commonly referred to as dry mouth, is a medical condition where the flow of saliva in the mouth is reduced or completely absent. Xerostomia is not categorized as a particular disease entity but is a symptom associated with decreased or lack of salivary secretion. Its effects on oral health and overall well-being can be significant and it can be caused by various factors such as medication use, radiation therapy, surgery, salivary gland problems, and other underlying medical conditions. A health-care professional typically diagnoses xerostomia by evaluating a patient’s symptoms and conducting a physical clinical exam. The patient’s medical and medication history may also be reviewed to identify any potential underlying causes. Decreased salivary secretion can make chewing, breaking up the food and the formation of a food bolus difficult, which increases the risk of incorrect swallowing as well as altered taste and can contribute to the experience of dysphagia. It is crucial for individuals experiencing xerostomia to seek medical attention from a health-care professional to determine the underlying cause and develop a suitable management plan. Xerostomia represents a serious problem with medical and dental implications. The search for related articles was conducted through databases including PubMed, Science Direct, and Google Scholar. This comprehensive review article offers the latest insights into the origins, diagnosis, and treatment of xerostomia, with a particular focus on prevention. In addition, it recognizes the significant impact of innovative approaches in addressing xerostomia and highlights their valuable contribution to its management.

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Impact of low-level laser therapy on the quality of life of patients with xerostomia undergoing head and neck radiotherapy: a systematic review

Cited by 2 publications

References 34 publications

Extraoral photobiomodulation to prevent hyposalivation in patients treated with head and neck radiotherapy: randomized double-blind clinical trial

Extraoral photobiomodulation to prevent hyposalivation in patients treated with head and neck radiotherapy: randomized double-blind clinical trial

Xerostomia: Current Advancements and Insights in Biomedical and Biotechnology Research

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