Impact of low frequency transcranial magnetic stimulation on event-related brain potentials

Hansenne, Michel; Laloyaux, Olivier; Mardaga, S.; Ansseau, Marc

doi:10.1016/j.biopsycho.2004.01.004

Cited by 43 publications

(41 citation statements)

References 33 publications

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“…In contrast, no significant changes were observed in the N100, P200, or N200 [17]. In another study, lowfrequency rTMS applied to the right dorsolateral prefrontal cortex produced no significant alterations in the P300 ERP components [18].…”

Section: Introductionmentioning

confidence: 80%

Frequency-dependent effects of repetitive transcranial magnetic stimulation on the human brain

et al. 2012

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The aim of this study was to examine the effects of repetitive transcranial magnetic stimulation (rTMS) on human brain activity. The effects of low-frequency magnetic stimulation were evaluated by analyzing the P300 component of event-related potentials (ERPs). A figure eight-shaped flat coil was used to stimulate the region over the left or the right supramarginal gyrus, which is considered to be the origin of the P300 component. We examined the effect of rTMS on the latency of the P300 component in 14 healthy individuals by applying 100 magnetic pulses for each stimulus point. Stimulus frequencies were 1.00, 0.75, 0.50, and 0.25 Hz rTMS. The auditory oddball task was used to elicit the P300s before and shortly after rTMS. We found that P300 latencies varied according to the stimulation frequency and the hemisphere of rTMS application. A 1.00 Hz rTMS pulse train over the left supramarginal gyrus shortened the P300 latencies by ∼15 ms at Fz. A 0.5 Hz rTMS pulse train over the left supramarginal gyrus lengthened the P300 latencies by ∼15 ms at Fz. In contrast, 0.75 and 0.25 Hz rTMS pulse trains over the left supramarginal gyrus and 1.00, 0.75, 0.50, and 0.25 Hz rTMS pulse trains over the right supramarginal gyrus did not alter P300 latencies. These results indicate that rTMS frequency affects cognitive processing. We suggest that the effects of rTMS vary according to the activity of excitatory and inhibitory synapses. In addition, the effects of rTMS over the left supramarginal gyrus are dependent on stimulus frequency.

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Section: Introductionmentioning

confidence: 80%

Frequency-dependent effects of repetitive transcranial magnetic stimulation on the human brain

et al. 2012

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“…Indirect evidence of a different possible subcortical generator of the N 2 could be inferred by a delayed P 3 component while the N 2 was not altered after cortical inhibition by lowfrequency transcranial magnetic stimulation [34] .…”

Section: Discussionmentioning

confidence: 99%

The Auditory Oddball Paradigm in Patients with Vascular Cognitive Impairment: A Prolonged Latency of the N<sub>2</sub> Complex

Harten

Laman

Duijn

et al. 2006

Dement Geriatr Cogn Disord

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Objective: The event-related potential (ERP) evoked by the auditory oddball paradigm has been investigated mainly in patients with Alzheimer’s disease and in patients with different causes of subcortical dementia. Subcortical ischemic vascular disease (SIVD) seems to be an important cause of vascular cognitive impairment (VCI) frequently not fulfilling the criteria for dementia. Recognition of VCI is needed in order to provide adequate care and therapy. The aim of this study was to investigate the diagnostic value of the different elements of this response (N₁, N₂ complex and P₃ latencies) in a group of elderly patients with VCI caused by SIVD. Methods: The study population consisted of patients with a clinical and neuropsychological diagnosis of VCI caused by SIVD (n = 38) and healthy control subjects (n = 53) aged 60 years or older. The mean Mini Mental State Examination score of both groups was 27.6, and the mean HIV Dementia Scale score was 6.1 in the patient group and 12.3 in the control group. In all subjects, the ERP was recorded under standardized conditions, and the latencies and amplitudes of N₁, N₂ and P₃ were analyzed by two clinical neurophysiologists in consensus. Both were blinded to the diagnosis. Results: The N₂ latency was significantly longer in patients with VCI than in age-matched controls, whereas the latencies of the P₃ and N₁ were not significantly different. The peak-to-peak amplitude of the N₂ complex to the P₃ wave was significantly lower in the patient group. White matter abnormalities on MRI were not significantly correlated with the N₂ latency. Conclusion: Our findings suggest that the latency of the N₂ complex is prolonged and the peak-to-peak amplitude of the N₂ complex to the P₃ wave is lowered in patients with VCI caused by SIVD.

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“…Most of the research was focused on visual or spatial attention. Studies on the effects of TMS to auditory attention by using EEG are still lacking, with only a few results reported (e.g., [16], [17], [18], [19]). Especially, rTMS has the potential advantage of disrupting brain activity for the duration of train of pulses, making it much easier to detect processing changes in studies of cognitive function as well as in studies of sensory and motor function.…”

Section: Introductionmentioning

confidence: 97%

An investigation on the effects of single pulse transcranial magnetic stimulation in a modified maximum entropy auditory stimulation paradigm

Low

Schwerdtfeger

Harris

et al. 2009

2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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In this paper, we intend to investigate further the effects of single pulse TMS (sTMS) on auditory attention through an experimental design that combines a modified version of maximum entropy stimulation paradigm. Single pulses of TMS with 4.4s inter-stimulus interval (ISI) were applied to the left temporal lobe of subjects while three randomized auditory stimuli with constant ISI of 1.1s were delivered to the contralateral side within the TMS stimulation duration. Our main focus was to examine the time course of the auditory late responses (ALRs) due to TMS stimulation by a phase clustering on the unit circle measure and an adaptive shift- invariant feature extraction method. In the attention scheme, a significant difference in the phase stability between TMS and no-TMS was found in the range of the N1 wave of ALRs. However, the difference occurs only for the data after 1.1s. Furthermore, there is an absence of differences in the amplitude of the ALR. In addition, the effects of TMS and attention can also be discriminated very well and illuminate the effects of TMS in auditory attention. It is concluded that even sTMS might have the potential to alter the attentional states and the effects can last about 1s, at least when considering the large- scale neural correlates of attention in ALR sequences.

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Impact of low frequency transcranial magnetic stimulation on event-related brain potentials

Cited by 43 publications

References 33 publications

Frequency-dependent effects of repetitive transcranial magnetic stimulation on the human brain

Frequency-dependent effects of repetitive transcranial magnetic stimulation on the human brain

The Auditory Oddball Paradigm in Patients with Vascular Cognitive Impairment: A Prolonged Latency of the N<sub>2</sub> Complex

An investigation on the effects of single pulse transcranial magnetic stimulation in a modified maximum entropy auditory stimulation paradigm

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