Impact of low-dose computed tomography screening on lung cancer mortality among asbestos-exposed workers

Barbone, Fabio; Barbiero, Fabiano; Belvedere, Ornella; Rosolen, Valentina; Giangreco, Manuela; Zanin, Tina; Pisa, Federica Edith; Meduri, Stefano; Follador, A.; Grossi, Francesco; Fasola, Gianpiero

doi:10.1093/ije/dyy212

Cited by 13 publications

(11 citation statements)

References 26 publications

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“…Additionally, from the high-risk individuals, ex-smokers were more likely than current smokers to consent to participate in the RCT (49.9% vs. 42.1%; P<0.0001) (15). Barbone et al [2018] found that participants were more likely to have quit smoking (46). The same results were found by Tonge et al…”

Section: Ex-smokers Vs Smokerssupporting

confidence: 69%

Lung cancer screening: targeting the hard to reach—a review

Hal¹,

Garcia²

2021

Transl Lung Cancer Res

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Lung cancer (LC) is the leading cause of cancer death in the USA for both men and women (1). Also worldwide, LC is the commonest cause of cancer death (2). Of all LC cases, smoking is implicated in more than 90% and prognosis is poor, with mortality close to 85% (3).However, the earlier the stage at which LC is detected, the better the prognosis. In November 2011, the first large multicenter randomized control trial-the National Lung Screening Trial (NLST) in the USA-released their results that showed that screening with chest low-dose computed tomography (LDCT) could reduce LC mortality by 20% (4,5). In the meantime, the NELSON trial in The Netherlands and Belgium also released its results (6). They found that screening with chest LDCT can reduce cause-Review Article on Lung Cancer Screening

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Section: Ex-smokers Vs Smokerssupporting

confidence: 69%

Lung cancer screening: targeting the hard to reach—a review

Hal¹,

Garcia²

2021

Transl Lung Cancer Res

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“…Barbone and colleagues examined nine-year mortality follow-up of a non-randomized study of 926 asbestos-exposed workers who were enrolled in an asbestos surveillance program in Northeastern Italy, a major shipbuilding area. The group had undergone at least two periodic LDCT scans beginning in 2002 [ 38 , 45 ]. They were mostly men with a mean age of 58 years at study onset and a long history of exposure to asbestos (mean duration of 30 years); one-third never smoked, and median pack-years of cigarettes among smokers was 18.5.…”

Section: Current Knowledgementioning

confidence: 99%

Lung Cancer Screening in Asbestos-Exposed Populations

Markowitz

2022

IJERPH

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Asbestos exposure is the most important cause of occupational lung cancer mortality. Two large randomized clinical trials in the U.S. and Europe conclusively demonstrate that annual low-dose chest CT (LDCT) scan screening reduces lung cancer mortality. Age and smoking are the chief risk factors tested in LDCT studies, but numerous risk prediction models that incorporate additional lung cancer risk factors have shown excellent performance. The studies of LDCT in asbestos-exposed populations shows favorable results but are variable in design and limited in size and generalizability. Outstanding questions include how to: (1) identify workers appropriate for screening, (2) organize screening programs, (3) inform and motivate people to screen, and (4) incorporate asbestos exposure into LDCT decision-making in clinical practice. Conclusion: Screening workers aged ≥50 years with a history of ≥5 years asbestos exposure (or fewer years given intense exposure) in combination with either (a) a history of smoking at least 10 pack-years with no limit on time since quitting, or (b) a history of asbestos-related fibrosis, chronic lung disease, family history of lung cancer, personal history of cancer, or exposure to multiple workplace lung carcinogens is a reasonable approach to LDCT eligibility, given current knowledge. The promotion of LDCT-based screening among asbestos-exposed workers is an urgent priority.

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“…The 2015 Helsinki Consensus Report [ 52 ] had in fact recommended LDCT-LCS in the following workers: (a) those with any asbestos exposure and a smoking history according to NLST criteria (smokers and former smokers, aged 55–74, with pack-year ≥30); or (b) those with asbestos exposure regardless of smoking history but who have an estimated risk equal to that of NLST [ 5 ] study population. However, there is only limited evidence to support the use of LDCT-LCS in asbestos-exposed persons and other exposed workers [ 53 , 54 ]. Furthermore, most studies investigating LDCT-LCS in asbestos-exposed persons did not perform risk estimation to identify high-risk individuals for asbestos exposure [ 51 ].…”

Section: Eligibly Criteria For Ldct-lcsmentioning

confidence: 99%

“…However, such data are often difficult to get. Use of validated questionnaires and checklists administered by trained interviewers are the most reliable means to identify persons with a work significant history of asbestos exposure [ 52 , 53 , 54 , 55 , 56 ], particularly when corroborated with data coming from the literature or databases on asbestos fibres content per air volume unit in workplaces [ 57 , 58 ]. Nevertheless, as people change jobs, it can be challenging to reconstruct occupational history and make precise estimations of asbestos exposure.…”

Section: Eligibly Criteria For Ldct-lcsmentioning

confidence: 99%

Recommendations for Implementing Lung Cancer Screening with Low-Dose Computed Tomography in Europe

Veronesi

Baldwin

Henschke

et al. 2020

Cancers

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Lung cancer screening (LCS) with low-dose computed tomography (LDCT) was demonstrated in the National Lung Screening Trial (NLST) to reduce mortality from the disease. European mortality data has recently become available from the Nelson randomised controlled trial, which confirmed lung cancer mortality reductions by 26% in men and 39–61% in women. Recent studies in Europe and the USA also showed positive results in screening workers exposed to asbestos. All European experts attending the “Initiative for European Lung Screening (IELS)”—a large international group of physicians and other experts concerned with lung cancer—agreed that LDCT-LCS should be implemented in Europe. However, the economic impact of LDCT-LCS and guidelines for its effective and safe implementation still need to be formulated. To this purpose, the IELS was asked to prepare recommendations to implement LCS and examine outstanding issues. A subgroup carried out a comprehensive literature review on LDCT-LCS and presented findings at a meeting held in Milan in November 2018. The present recommendations reflect that consensus was reached.

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Impact of low-dose computed tomography screening on lung cancer mortality among asbestos-exposed workers

Cited by 13 publications

References 26 publications

Lung cancer screening: targeting the hard to reach—a review

Lung cancer screening: targeting the hard to reach—a review

Lung Cancer Screening in Asbestos-Exposed Populations

Recommendations for Implementing Lung Cancer Screening with Low-Dose Computed Tomography in Europe

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