Impact of low-dose chronic exposure to bisphenol A and its analogue bisphenol B, bisphenol F and bisphenol S on hypothalamo-pituitary-testicular activities in adult rats: A focus on the possible hormonal mode of action

Ullah, Asad; Pirzada, Madeeha; Jahan, Sarwat; Ullah, Hanif; Turi, Naheed; Ullah, Waheed; Siddiqui, Mariyam Fatima; Zakria, Muhammad; Lodhi, Kinza Zafar; Khan, Muhammad Munir

doi:10.1016/j.fct.2018.08.024

Cited by 91 publications

(64 citation statements)

References 81 publications

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“…In vivo studies of 5 mg/kg/day of BPA, BPB, BPF, and BPS exposed to adult male rats for 28 days showed that they led to decreased T levels and increased ROS levels (165). Male prepubertal rats exposed to 5, 25, and 50 µg/L BPA, BPB, BPF, and BPS in drinking water for 48 weeks also showed a decrease in T levels in the highest dose group (166). These results indicate that BPA analogs BPB, BPF, and BPS have similar effects on the development of the male reproductive system to BPA.…”

Section: In Vivo Studies Of Bpa Analogsmentioning

confidence: 96%

Bisphenols and Leydig Cell Development and Function

Zhu²,

Wang

et al. 2020

Front. Endocrinol.

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Bisphenol A (BPA) is a ubiquitous environmental pollutant, mainly from the production and use of plastics and the degradation of wastes related to industrial plastics. Evidence from laboratory animal and human studies supports the view that BPA has an endocrine disrupting effect on Leydig cell development and function. To better understand the adverse effects of BPA, we reviewed its role and mechanism by analyzing rodent data in vivo and in vitro and human epidemiological evidence. BPA has estrogen and anti-androgen effects, thereby destroying the development and function of Leydig cells and causing related reproductive diseases such as testicular dysgenesis syndrome, delayed puberty, and subfertility/infertility. Due to the limitation of BPA production, the increased use of BPA analogs has also attracted attention to these new chemicals. They may share actions and mechanisms similar to or different from BPA.

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Section: In Vivo Studies Of Bpa Analogsmentioning

confidence: 96%

Bisphenols and Leydig Cell Development and Function

Zhu²,

Wang

et al. 2020

Front. Endocrinol.

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“…There is also evidence of marked histological alterations of male reproductive tract in the offspring of Sprague Dawley rats exposed to various concentrations of BPA and analogues: in particular, the authors detected reduced seminiferous tubules diameters in post-natal male pups and increased oxidative stress markers [54].…”

Section: Pre-natal Exposure: Can Testicular Function Already Be Comprmentioning

confidence: 98%

Mechanisms of Testicular Disruption from Exposure to Bisphenol A and Phtalates

Pallotti

Pelloni

Gianfrilli

et al. 2020

JCM

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Great attention has been paid in recent years to the harmful effects of various chemicals that interfere with our natural hormone balance, collectively known as endocrine-disrupting chemicals (EDCs) or endocrine disruptors. The effects on the reproductive system of bisphenol A (BPA) and phthalates have received particular attention: while they have a short half-life, they are so widespread that human exposure can be considered as continuous. Evidence is often limited to the animal model, disregarding the likelihood of human exposure to a mixture of contaminants. Data from animal models show that maternal exposure probably has harmful effects on the male fetus, with an increased risk of urogenital developmental abnormalities. After birth, exposure is associated with changes in the hypothalamic-pituitary-testicular axis, hindering the development and function of the male genital pathways through the mediation of inflammatory mechanisms and oxidative stress. The epidemiological and clinical evidence, while generally confirming the association between reproductive abnormalities and some phthalate esters and BPA, is more contradictory, with wildly different findings. The aim of this review is therefore to provide an update of the potential mechanisms of the damage caused by BPA and phthalates to reproductive function and a review of the clinical evidence currently available in the literature.

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“…Bisphenol toxicity studies have revealed that these chemicals disrupt the endocrine functions and cause reproductive toxicity [43][44][45][46]. Even a low dose of chronic exposure to bisphenols suppresses the luteinizing hormone, follicle-stimulating hormones, and prolactin, exhibiting estrogenic and antiandrogenic effects and affecting spermatogenesis [12,47,48]. Common reproductive abnormalities include premature puberty, ovarian dysfunction, implantation failure, abnormal sperm function, fertilization failure, sex hormone abnormality, premature birth, and lower birth weight [48][49][50][51][52].…”

Section: Endocrine Disruption and Reproductive Abnormalitiesmentioning

confidence: 99%

Bisphenols as a Legacy Pollutant, and Their Effects on Organ Vulnerability

Kim

Kumar

et al. 2019

IJERPH

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Bisphenols are widely used in the synthesis of polycarbonate plastics, epoxy resins, and thermal paper, which are used in manufacturing items of daily use. Packaged foods and drinks are the main sources of exposure to bisphenols. These chemicals affect humans and animals by disrupting the estrogen, androgen, progesterone, thyroid, and aryl hydrocarbon receptor functions. Bisphenols exert numerous harmful effects because of their interaction with receptors, reactive oxygen species (ROS) formation, lipid peroxidation, mitochondrial dysfunction, and cell signal alterations. Both cohort and case-control studies have determined an association between bisphenol exposure and increased risk of cardiovascular diseases, neurological disorders, reproductive abnormalities, obesity, and diabetes. Prenatal exposure to bisphenols results in developmental disorders in animals. These chemicals also affect the immune cells and play a significant role in initiating the inflammatory response. Exposure to bisphenols exhibit age, gender, and dose-dependent effects. Even at low concentrations, bisphenols exert toxicity, and hence deserve a critical assessment of their uses. Since bisphenols have a global influence on human health, the need to discover the underlying pathways involved in all disease conditions is essential. Furthermore, it is important to promote the use of alternatives for bisphenols, thereby restricting their uses.

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Impact of low-dose chronic exposure to bisphenol A and its analogue bisphenol B, bisphenol F and bisphenol S on hypothalamo-pituitary-testicular activities in adult rats: A focus on the possible hormonal mode of action

Cited by 91 publications

References 81 publications

Bisphenols and Leydig Cell Development and Function

Bisphenols and Leydig Cell Development and Function

Mechanisms of Testicular Disruption from Exposure to Bisphenol A and Phtalates

Bisphenols as a Legacy Pollutant, and Their Effects on Organ Vulnerability

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