Impact of Low Birth Weight and Cardiovascular Risk Factors on Endothelial Function in Early Adult Life

Leeson, C. P. M.; Kattenhorn, M; Morley, Ruth; Lucas, Alan; Deanfield, John

doi:10.1161/01.cir.103.9.1264

Cited by 330 publications

(230 citation statements)

References 37 publications

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“…Adults known to have had intrauterine growth retardation have been shown to exhibit abnormalities of peripheral endothelial function. 327 Remarkably, adults with low birth weight who otherwise had a low-risk cardiovascular profile (nonsmoker, normal blood pressure, and normal weight) have been shown to have vascular dysfunction similar to the risk of individuals who smoked 4.5 cigarette pack-years. 328 Genetic-environment interactions are ubiquitous in human development.…”

Section: Effect Of Prenatal/early Childhood Deprivation On Cvd Incidementioning

confidence: 99%

Social Determinants of Risk and Outcomes for Cardiovascular Disease

Havranek¹,

Mujahid²,

Barr³

et al. 2015

Circulation

1,101

732

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Section: Effect Of Prenatal/early Childhood Deprivation On Cvd Incidementioning

confidence: 99%

Social Determinants of Risk and Outcomes for Cardiovascular Disease

Havranek¹,

Mujahid²,

Barr³

et al. 2015

Circulation

1,101

732

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“…A recent study has shown a relationship between low birth weight and endothelial dysfunction in young adults that was most marked in individuals with lower risk factor profiles. This suggests that the association does not operate via increased risk factors, such as cholesterol and blood pressure, and that early growth may directly influence the blood vessel wall (Leeson et al, 2001). Further studies are needed to understand fully the different pathways in programming of adult diseases.…”

Section: Figurementioning

confidence: 99%

Association between size at birth, truncal fat and obesity in adult life and its contribution to blood pressure and coronary heart disease; study in a high birth weight population

et al. 2004

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Objective: The aim of the study was to assess the relationship between size at birth and obesity as well as truncal fat, and its contribution to cardiovascular risk in a high birth weight population. Design: Cohort-study with retrospectively collected data on size at birth. Setting: Reykjavik, Iceland. Subjects: A total of 1874 men and 1833 women born in Reykjavik during . Main outcome measures: Size at birth. Adult weight, height and skinfold thickness measurements, systolic and diastolic blood pressure, fatal and nonfatal coronary heart disease (CHD). Results: Birth weight was positively related to adult body mass index (BMI) in both genders (B¼0.3570.14 kg/m 2 , adj. R 2 ¼0.015, P¼0.012 and B¼0.3470.17 kg/m 2 , adj. R 2 ¼0.055, P¼0.043 in men and women, respectively). However, high birth weight was not a risk factor for adult obesity (BMIZ30 kg/m 2 ). In the highest birth weight quartile, the odds ratio (95% CI) for being above the 90th percentile of truncal fat was 0.7 (0.6-1.0, P¼0.021) for men and 0.4 (0.3-0.8, P¼0.002) for women, compared with the lowest birth weight quartile. Truncal fat and BMI were positively related to blood pressure in both genders (Po0.05), but not to CHD. The regression coefficient for the inverse association between birth weight and blood pressure hardly changed when adding truncal fat to the model. Conclusion: In this high birth weight population, high birth weight was related to higher BMI in adulthood without being a risk factor for adult obesity. The inverse association between birth weight and truncal fat in adulthood suggests a role for foetal development in determining adult fat distribution. The inverse relationship of birth weight to blood pressure seems not to be mediated through the same pathway as to truncal fat.

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“…7,25,29 All of the adolescents in the present study were born fullterm and with adequate weight, however we do not have information on their rates of growth during their first weeks of life (Table 1). …”

Section: Variablesmentioning

confidence: 99%

“…5 Studies have found evidence of abnormal endothelial function in people with risk factors for arterial hypertension and atherosclerosis, such as obesity, familial hypercholesterolemia, family history of arterial hypertension and low birth weight. [6][7][8] These studies assessed endothelial function by means of high-resolution B-mode ultrasound, a methodology that is widely used to evaluate endotheliumdependent vascular dilatation. This dilatation is a function of NO, which is a potent vasodilator and is produced by endothelial cells in response to stimulation from blood in contact with the vessel walls.…”

Section: Introductionmentioning

confidence: 99%

Função endotelial de adolescentes normotensos sem fatores de risco para hipertensão arterial

Andrade¹,

Carvalhaes²,

Taddei³

et al. 2005

J. Pediatr. (Rio J.)

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Objective: To define standards for normal endothelial function in adolescents by high-resolution ultrasound measurement of endothelium-dependent vascular dilatation.Methods: This was a cross-sectional, descriptive, observational study and part of the thematic project Clinical Study of Growth, Behavior, Arterial Hypertension, Obesity and Oral Health (ECCCHOS) that was developed by the Discipline of Nutrition at the Universidade Federal de São Paulo. Thirty-one adolescents, eight male and 23 female, with no risk factors for systemic arterial hypertension were selected from 1,420 high-school students. The students were daytime pupils at a school in the southeastern district of the city of São Paulo, the capital of São Paulo state, located in the Southeast region of Brazil. All results are presented in the form of means with standard deviations and percentiles.Results: For male students, endothelium-dependant dilation 90 seconds after the cuff was released was 20.9±6,7% [mean ±1 standard deviation] with a 10th percentile of 12.5 and for females these figures were 18.8±12.9% with a 10th percentile of 6.6%. Values for the whole group of subjects were 19.3±11.7% and 6.7%, respectively.Conclusion: Endothelium-dependant vascular dilation of 6.7%, after 90 seconds, which corresponds to the 10th percentile, can be considered the lower limit of normality for this age group. Knowledge of this limit is important for the diagnosis of endothelium dysfunction that appears before cardiovascular disease.J Pediatr (Rio J). 2005;81(5):395-9: Adolescents, endothelium, and ultrasound.

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Impact of Low Birth Weight and Cardiovascular Risk Factors on Endothelial Function in Early Adult Life

Cited by 330 publications

References 37 publications

Social Determinants of Risk and Outcomes for Cardiovascular Disease

Social Determinants of Risk and Outcomes for Cardiovascular Disease

Association between size at birth, truncal fat and obesity in adult life and its contribution to blood pressure and coronary heart disease; study in a high birth weight population

Função endotelial de adolescentes normotensos sem fatores de risco para hipertensão arterial

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