Impact of long-term caloric restriction on cardiac senescence: Caloric restriction ameliorates cardiac diastolic dysfunction associated with aging

Shinmura, Ken; Tamaki, Kunihiko; Sano, Motoaki; Murata, Mitsushige; Yamakawa, Hiroyuki; Ishida, Hideyuki; Fukuda, Keiichi

doi:10.1016/j.yjmcc.2010.10.018

Cited by 151 publications

(137 citation statements)

References 43 publications

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“…Although exercising regularly, our findings continue to suggest that the decline in LV diastolic filling is inevitable (Bradshaw et al 2010;Groban et al 2008;Lee et al 2012;Shinmura et al 2011;Turner et al 2013). Yet, the benefit of regular lifelong physical activity is greater passive filling velocities for the SHAM mice throughout a majority of the lifespan.…”

Section: Discussionsupporting

confidence: 51%

Altered left ventricular performance in aging physically active mice with an ankle sprain injury

Turner

Guderian

Wikstrom

et al. 2016

AGE

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We assessed the impact of differing physical activity levels throughout the lifespan, using a musculoskeletal injury model, on the age-related changes in left ventricular (LV) parameters in active mice. Forty male mice (CBA/J) were randomly placed into one of three running wheel groups (transected CFL group, transected ATFL/CFL group, SHAM group) or a SHAM Sedentary group (SHAMSED). Before surgery and every 6 weeks after surgery, LV parameters were measured under 2.5 % isoflurane inhalation. Group effects for daily distance run was significantly greater for the SHAM and lesser for the ATLF/CFL mice (p = 0.013) with distance run decreasing with age for all mice (p < 0.0001). Beginning at 6 months of age, interaction (group × age) was noted with LV posterior wall thickness-to-radius ratios (h/r) where h/r increased with age in the ATFL/CFL and SHAMSED mice while the SHAM and CFL mice exhibited decreased h/r with age (p = 0.0002). Passive filling velocity (E wave) was significantly greater in the SHAM mice and lowest for the ATFL/CFL and SHAMSED mice (p < 0.0001) beginning at 9 months of age. Active filling velocity (A wave) was not different between groups (p = 0.10). Passive-to-active filling velocity ratio (E/A ratio) was different between groups (p < 0.0001), with higher ratios for the SHAM mice and lower ratios for the ATFL/CFL and SHAMSED mice in response to physical activity beginning at 9 months of age. Passive-toactive filling velocity ratio decreased with age (p < 0.0001). Regular physical activity throughout the lifespan improved LV structure, passive filling velocity, and E/A ratio by 6 to 9 months of age and attenuated any negative alterations throughout the second half of life. The diastolic filling differences were found to be significantly related to the amount of activity performed by 9 months and at the end of the lifespan.

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Section: Discussionsupporting

confidence: 51%

Altered left ventricular performance in aging physically active mice with an ankle sprain injury

Turner

Guderian

Wikstrom

et al. 2016

AGE

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“…Caloric restriction is believed to reduce cardiovascular risk factors and slow down heart aging via reduction of mitochondrial reactive oxygen species in plasma and heart tissues (Minamiyama et al, 2007;Shinmura et al, 2011). On the other hand, several CR effects leading to alterations in gene expression and protein profile and deterioration of heart function have been reported (Katzeff et al, 1997;Sugizaki et al, 2009Sugizaki et al, , 2011Yamagishi et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

The effects of caloric restriction and age on thyroid hormone signalling in the heart of rats

Lachowicz¹,

Fürstenberg²,

Pałkowska³

et al. 2014

J. Anim. Feed Sci.

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“…Almost all of these studies have initiated CR in young animals to see the extent to which the effects of aging are protected. While CR has not been studied extensively in aging cardiomyopathy, there are a few studies in rodents and humans suggesting that CR did not prevent, but at least partially ameliorated, aging cardiomyopathy (Niemann et al 2010;Shinmura et al 2011;Weiss and Fontana 2011). Again in these studies, CR was initiated in young animals.…”

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confidence: 99%

Calorie restriction can reverse, as well as prevent, aging cardiomyopathy

Yan

Gao

et al. 2013

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Calorie restriction (CR) is the most widely studied intervention protecting from the adverse effects of aging. Almost all prior studies have examined the effects of CR initiated in young animals. Studies examining the effects of CR on development of aging cardiomyopathy found only partial prevention. The major goal of this study was to determine whether CR initiated after aging cardiomyopathy developed could reverse the cardiomyopathy. Aging cardiomyopathy in 2-year-old mice was characterized by reduced left ventricular (LV) function, cardiac hypertrophy, and increased cardiac apoptosis and fibrosis. When short-term (2 months) CR was initiated after aging cardiomyopathy developed in 20-month-old mice, the decrease in cardiac function, and increases in LV weight, myocardial fibrosis and apoptosis were reversed, such that the aging hearts in these mice were indistinguishable from those of young mice or mice where CR was initiated in young mice. If apoptosis was the mechanism for protecting against aging cardiomyopathy, then total myocyte numbers should have reverted to normal with CR, but did not. However, the alterations in cytoskeletal proteins, which contribute to aging cardiomyopathy, were no longer observed with CR. This is the first study to demonstrate complete prevention of aging cardiomyopathy by CR and, more importantly, that instituting this intervention even later in life can rapidly correct aging cardiomyopathy, which could have important therapeutic implications.

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Impact of long-term caloric restriction on cardiac senescence: Caloric restriction ameliorates cardiac diastolic dysfunction associated with aging

Cited by 151 publications

References 43 publications

Altered left ventricular performance in aging physically active mice with an ankle sprain injury

Altered left ventricular performance in aging physically active mice with an ankle sprain injury

The effects of caloric restriction and age on thyroid hormone signalling in the heart of rats

Calorie restriction can reverse, as well as prevent, aging cardiomyopathy

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