Impact of local and systemic factors on the incidence of late oral implant loss

Alsaadi, Ghada; Quirynen, Marc; Komárek, Arnošt; Steenberghe, Daniël van

doi:10.1111/j.1600-0501.2008.01534.x

Cited by 185 publications

(292 citation statements)

References 29 publications

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“…16 The authors found no significant differences in late failure between normal and hypertensive individuals. 16 However, the impact of hypertension on early implant failures rate, which is directly related to the wound healing process in the early stage of osseointegration, has never been tested.…”

Section: Introductionmentioning

confidence: 79%

“…8,9 Although the hypothesis that hypertension may have a harmful effect on bone density was previously evaluated in a series of animal and clinical studies, [10][11][12][13][14] to date, few investigations have focused on the influence of hypertension on bone healing. 15 Currently the hypothesis that the hypertension could lead to an increased incidence of late implant loss was evaluated by Alsaadi et al (2008). 16 The authors found no significant differences in late failure between normal and hypertensive individuals.…”

Section: Introductionmentioning

confidence: 99%

“…15 Currently the hypothesis that the hypertension could lead to an increased incidence of late implant loss was evaluated by Alsaadi et al (2008). 16 The authors found no significant differences in late failure between normal and hypertensive individuals. 16 However, the impact of hypertension on early implant failures rate, which is directly related to the wound healing process in the early stage of osseointegration, has never been tested.…”

Section: Introductionmentioning

confidence: 99%

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Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study

et al. 2010

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Abstract:Clinical and experimental studies have demonstrated some negative effect of hypertension on bone mineral density. The aim of this study was to evaluate bone healing and trabecular bone area (TBA) in spontaneously hypertensive rats (SHR), a well-established model of essential hypertension, when compared to normotensive rats (NTR). A critical-size defect was surgically created in the right tibia of SHR (n = 12) and normotensive rats (NTR; n = 12), while the contralateral tibia was left intact. Eight days later, the animals were sacrificed and the specimens processed in order to obtain decalcified sections. The area of newly-formed bone (NB) within the defect of the right tibia and the TBA in the left tibia were histometrically evaluated. At 8 days post-operative, SHR presented a significantly smaller area of NB when compared to NTR (p < 0.05). In addition, SHR demonstrated a lower TBA than NTR group. In conclusion, the present study demonstrated that SHR rats presented a disturbed bone healing and reduced TBA.

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Section: Introductionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study

et al. 2010

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“…The meta-analysis included 7 controlled clinical trials (Morris et al, 2000;van Steenberghe et al, 2002;Dowell et al, 2007;Alsaadi et al, 2008a;Tawil et al, 2008;Levin et al, 2011;Grandi et al, 2013) and 7 retrospective analyses (Keller et al, 1999;Accursi, 2000;Doyle et al, 2007;Alsaadi et al, 2008b;Anner et al, 2010;Bell et al, 2011;Le et al, 2013). The study of Grandi et al (2013) was a randomized clinical trial for immediately vs. early loaded implants but not for diabetic vs. non-diabetic patients.…”

Section: Description Of the Studiesmentioning

confidence: 99%

Diabetes and Oral Implant Failure

2014

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The aim of this systematic review and meta-analysis was to investigate whether there are any effects of diabetes mellitus on implant failure rates, postoperative infections, and marginal bone loss. An electronic search without time or language restrictions was undertaken in March 2014. The present review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Eligibility criteria included clinical human studies. The search strategy resulted in 14 publications. The I 2 statistic was used to express the percentage of total variation across studies due to heterogeneity. The inverse variance method was used for the random effects model when heterogeneity was detected or for the fixed effects model when heterogeneity was not detected. The estimates of an intervention for dichotomous outcomes were expressed in risk ratio and in mean difference in millimeters for continuous outcomes, both with a 95% confidence interval. There was a statistically significant difference (p = .001; mean difference = 0.20, 95% confidence interval = 0.08, 0.31) between diabetic and non-diabetic patients concerning marginal bone loss, favoring non-diabetic patients. A meta-analysis was not possible for postoperative infections. The difference between the patients (diabetic vs. non-diabetic) did not significantly affect implant failure rates (p = .65), with a risk ratio of 1.07 (95% confidence interval = 0.80, 1.44). Studies are lacking that include both patient types, with larger sample sizes, and that report the outcome data separately for each group. The results of the present metaanalysis should be interpreted with caution because of the presence of uncontrolled confounding factors in the included studies.

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“…Treatment success versus failure factors include the biomechanical condition, the microbial environment, and the host bone quality and quantity [2]. The latter factor is closely associated with systemic diseases associated with ageing, such as osteoporosis and diabetes.…”

Section: Introductionmentioning

confidence: 99%

High-frequency loading positively impacts titanium implant osseointegration in impaired bone

et al. 2014

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Summary High-frequency loading via whole body vibration promotes bone formation and increases bone strength. Whether this translates to positive titanium implant osseointegration in osteoporotic bone was explored in this animal study. An anabolic effect of not only bisphosphonate treatment but also high-frequency loading on implant osseointegration in osteoporotic bone was observed. Introduction The present study investigated the impact of high-frequency (HF) loading, applied via whole body vibration (WBV), on titanium implant osseointegration in healthy versus ovariectomyinduced compromised versus pharmacologically treated compromised bone. Methods A custom-made Ti implant was inserted into the metaphyseal tibia of 59 rats and left to heal for either 4 or 14 days. Rats were divided into six groups according to their hormonal and mechanical status. WBV, consisting of 10 consecutive frequency steps at an acceleration of 0.3g, was applied daily for either 4 or 14 days. Tissue samples were processed for quantitative histology at the tibial cortical and medullar level. Data were analyzed by three-way ANOVA and by post hoc pairwise comparisons. Results The bone healing response at the interface and surrounding titanium implants was negatively influenced by osteoporotic bone conditions, mainly at the trabecular bone level. Furthermore, the administration of bisphosphonates for preventing the ovariectomy-induced impaired periimplant response was successful. Finally, the effect of HF WBV loading on the peri-implant bone healing was dependent on the bone condition and was anabolic solely in untreated osteoporotic trabecular bone when applied for an extended period of time. ConclusionsThe bone healing response to implant installation is compromised in osteoporotic bone conditions, in particular at the trabecular bone compartment. Meanwhile, not only pharmacological treatment but also mechanical loading via HF WBV can exert a positive effect on implant osseointegration in this specific bone micro-environment. The peri-implant cortical bone, however, seems to be less sensitive to HF WBV loading influences.

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Impact of local and systemic factors on the incidence of late oral implant loss

Abstract: Implant location in the oral cavity and radiotherapy seem predominant to explain the occurrence of implant loss. On the other hand, smoking and systemic health factors do not seem to be prominent players in the etiology of late implant loss.

Cited by 185 publications

References 29 publications

Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study

Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study

Diabetes and Oral Implant Failure

High-frequency loading positively impacts titanium implant osseointegration in impaired bone

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