Impact of LncRNA GAS5 Genetic Variants and the Epidermal Growth Factor Receptor Phenotypes on the Clinicopathological Characteristics of Lung Adenocarcinoma Patients

Hsieh, Ming‐Hong; Wu, Yiliang; Tsao, Thomas Chang-Yao; Huang, Yi-Wen; Lin, Jizhen; Lee, Chia-Yi; Hsieh, Ming‐Ju; Yang, Shun‐Fa

doi:10.3390/ijerph19169971

Cited by 5 publications

(4 citation statements)

References 35 publications

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“…In recent years, studies have also revealed that genetic polymorphisms of MALAT1 have susceptibility to cancers [ 31 , 32 , 40 ]. In our study, the cohort of LUAD demographics and fundamental traits were comparable to those of previous Asian cohort [ 48 , 49 ]; these cohort also showed that LUAD patients with an EGFR mutation were more likely to be female, never-smokers, and to have better cell differentiation than the EGFR wild-type group. The absence of smoking was linked to the development of LUAD, whereas EGFR mutations were more common among never-smoker ( Table 1 ).…”

Section: Discussionsupporting

confidence: 81%

Evaluation of the clinical significance of long non-coding RNA MALAT1 genetic variants in human lung adenocarcinoma

Lin,

Lu,

Hsieh

et al. 2024

Aging

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Lung adenocarcinoma (LUAD) is the most frequent histological subtype of lung cancer, which is the most common malignant tumor and the main cause of cancer-related mortality globally. Recent reports revealed that long non-coding RNA (lncRNA) of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) plays a crucial role in tumorigenesis and metastasis development in lung cancer. However, the contribution of MALAT1 genetic variants to the development of LUAD is unclear, especially in epidermal growth factor receptor (EGFR) mutation status. In this study, 272 LADC patients with different EGFR status were recruited to dissect the allelic discrimination of the MALAT1 polymorphisms at rs3200401, rs619586, and rs1194338. The findings of the study showed that MALAT1 polymorphisms rs3200401, rs619586, and rs1194338 were not associated to LUAD susceptibility; however, rs3200401 polymorphisms was significantly correlated to EGFR wild-type status and tumor stages in LUAD patients in dominant model (p=0.016). Further analyses using the datasets from The Cancer Genome Atlas (TCGA) revealed that lower MALAT1 mRNA levels were associated with the advanced stage, and lymph node metastasis in LADC patients. In conclusion, our results showed that MALAT1 rs3200401 polymorphisms dramatically raised the probability of LUAD development.

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Section: Discussionsupporting

confidence: 81%

Evaluation of the clinical significance of long non-coding RNA MALAT1 genetic variants in human lung adenocarcinoma

Lin,

Lu,

Hsieh

et al. 2024

Aging

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“…Based on published data, we observed that studies into the roles of GAS5, miR-25a-3p, and SOX11 in cancer or their connections to cancer have taken place. Hsieh et al [ 33 ] evaluated the influences of lncRNA GAS5 genetic variants on the clinicopathological characteristics of lung adenocarcinoma. Similarly, miR-25-3p was also identified as a stable tumor biomarker for its knockdown suppressed breast cancer cell proliferation and invasion[ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Construction of CDKN2A-related competitive endogenous RNA network and identification of GAS5 as a prognostic indicator for hepatocellular carcinoma

Pan,

Zhang,

Wang

et al. 2024

World J Gastrointest Oncol

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BACKGROUND Competitive endogenous RNA (ceRNA) is an innovative way of gene expression modulation, which plays a crucial part in neoplasia. However, the intricacy and behavioral characteristics of the ceRNA network in hepatocellular carcinoma (HCC) remain dismal. AIM To establish a cyclin dependent kinase inhibitor 2A (CDKN2A)-related ceRNA network and recognize potential prognostic indicators for HCC. METHODS The mutation landscape of CDKN2A in HCC was first explored using the cBioPortal database. Differential expression analysis was implemented between CDKN2Ahigh and CDKN2Alow expression HCC samples. The targeted microRNAs were predicted by lncBasev3.0, and the targeted mRNAs were predicted by miRDB, and Targetscan database. The univariate and multivariate analysis were utilized to identify independent prognostic indicators. RESULTS CDKN2A was frequently mutated and deleted in HCC. The single-cell RNA-sequencing analysis revealed that CDKN2A participated in cell cycle pathways. The CDKN2A-related ceRNA network-growth arrest specific 5 (GAS5)/miR-25-3p/SRY-box transcription factor 11 (SOX11) was successfully established. GAS5 was recognized as an independent prognostic biomarker, whose overexpression was correlated with a poor prognosis in HCC patients. The association between GAS5 expression and methylation, immune infiltration was explored. Besides, traditional Chinese medicine effective components targeting GAS5 were obtained. CONCLUSION This CDKN2A-related ceRNA network provides innovative insights into the molecular mechanism of HCC formation and progression. Moreover, GAS5 might be a significant prognostic biomarker and therapeutic target in HCC.

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“…Moreover, SNPs rs920778 and rs1899663 in lncRNA HOTAIR have been found to increase lung cancer susceptibility [140]. Epidermal growth factor receptor (EGFR) wild type lung adenocarcinoma, the GAS5 SNP rs145204276, may aid in tumor stage, distal metastases, and lymph node metastasis prediction [141]. PRNCR1 is an lncRNA located on chromosome 8q24.21 and is a popular oncogene in prostate cancer [142].…”

Section: Lncrnas Snps List In Lung Cancer Their Role and Mechanism Of...mentioning

confidence: 99%

The Intergenic Type LncRNA (LINC RNA) Faces in Cancer with In Silico Scope and a Directed Lens to LINC00511: A Step toward ncRNA Precision

Eldash,

Sanad,

Nada

et al. 2023

ncRNA

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Background: Long intergenic non-coding RNA, is one type of lncRNA, exerting various cellular activities, as does ncRNA, including the regulation of gene expression and chromatin remodeling. The abnormal expression of lincRNAs can induce or suppress carcinogenesis. Main body: LincRNAs can regulate cancer progression through different mechanisms and are considered as potential drug targets. Genetic variations such as single nucleotide polymorphisms (SNPs) in lincRNAs may affect gene expression and messenger ribonucleic acid (mRNA) stability. SNPs in lincRNAs have been found to be associated with different types of cancer, as well. Specifically, LINC00511 has been known to promote the progression of multiple malignancies such as breast cancer, colorectal cancer, lung cancer, hepatocellular carcinoma, and others, making it a promising cancer prognostic molecular marker. Conclusion: LincRNAs have been proved to be associated with different cancer types through various pathways. Herein, we performed a comprehensive literature and in silico databases search listing lncRNAs, lincRNAs including LINC00511, lncRNAs’ SNPs, as well as LINC00511 SNPs in different cancer types, focusing on their role in various cancer types and mechanism(s) of action.

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Impact of LncRNA GAS5 Genetic Variants and the Epidermal Growth Factor Receptor Phenotypes on the Clinicopathological Characteristics of Lung Adenocarcinoma Patients

Cited by 5 publications

References 35 publications

Evaluation of the clinical significance of long non-coding RNA MALAT1 genetic variants in human lung adenocarcinoma

Evaluation of the clinical significance of long non-coding RNA MALAT1 genetic variants in human lung adenocarcinoma

Construction of CDKN2A-related competitive endogenous RNA network and identification of GAS5 as a prognostic indicator for hepatocellular carcinoma

The Intergenic Type LncRNA (LINC RNA) Faces in Cancer with In Silico Scope and a Directed Lens to LINC00511: A Step toward ncRNA Precision

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