Impact of Living and Socioeconomic Characteristics on Cardiovascular Risk in Ischemic Stroke Patients

Amarenco, Pierre; Abboud, Halim; Labreuche, Julien; Araúz, Antonio; Bryer, Alan; Lavados, Pablo M.; Massaro, Ayrton Roberto; Collazos, Mario Muñoz; Steg, Philippe Gabriel; Yamout, Bassem; Vicaut, Éric

doi:10.1111/ijs.12290

Cited by 12 publications

(14 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We found a positive association between stroke and lower level of education in the index study which was also is similar to the report by Amarenco et al [48] who observed that low level of education, unemployment status and low quality of living were predictive of major vascular events. People in low level of education are more likely to earn less and affected by factors discussed earlier.…”

Section: Discussionsupporting

confidence: 91%

The Prevalence of Stroke Survivors in Urban Slums in Enugu, Nigeria

Ekenze¹,

Adikaibe²,

Obinna³

et al. 2019

OJPM

View full text Add to dashboard Cite

Background: Stroke is one of the commonest non-communicable diseases and the commonest cause of death in adult neurology wards. Stroke prevalence in sub Saharan Africa has dramatically increased over the past decades possibly due to changing life styles, poverty, poor health infrastructures which had led to increased risk factors for stroke. Poor nutrition and lack of access to standard medical care, predispose to high rates of stroke morbidity and mortality hence possible low prevalence. Little is known about the prevalence of stroke in people with low socio-economic status in Nigeria. Objectives: The main objective of this study was to determine the prevalence of stroke in two urban slums in south east Nigeria. Materials and Methods: This was a cross sectional descriptive study carried out in two slums in Enugu, South East Nigeria. Participants were screened using a stroke specific questionnaire and further examined by two independent neurologists for evidence of focal neurological deficits. Analysis was done by SPSS version 22. Results: A total of 1440 participants were surveyed in the study; 769 (53.4) females and 671 (46.6%) males. About 22.3% (321) screened positive for various neurological diseases out of which 17 (5.3%) had evidence for stroke giving an overall prevalence of 1.2% (males 9 (1.3%) vs females 8 (1%) p = 0.6). The mean age of stroke survivors was 60.1 years, similar in males and females (p = 0.6). The odds ratio for stroke from 40 years showed progress increment doubling between 60 and 70 years and tripled between 40 and 70 years. Age, lower level of education, positive history of hypertension, sickle How to cite this paper: Ekenze, O.

show abstract

Section: Discussionsupporting

confidence: 91%

The Prevalence of Stroke Survivors in Urban Slums in Enugu, Nigeria

Ekenze¹,

Adikaibe²,

Obinna³

et al. 2019

OJPM

View full text Add to dashboard Cite

show abstract

“…Similarly, regarding our previous OPTIC publication [10] showing an independent association of socioeconomics factors with cardiovascular risk, a multivariable model was performed by including socioeconomics factors as covariables. Thus, the following additional models were considered, which included model 1 variables plus hypertension, dyslipidemia, and smoking (model 2); model 2 variables plus body mass index and diabetes (model 3); and model 3 variables plus socioeconomic data (model 4).…”

Section: Methodsmentioning

confidence: 99%

Specificities of Ischemic Stroke Risk Factors in Arab-Speaking Countries

Abboud

Sissani²,

Labreuche³

et al. 2017

Cerebrovasc Dis

Self Cite

View full text Add to dashboard Cite

Background: Stroke is largely preventable, and therefore, a better understanding of risk factors is an essential step in reducing the population stroke rate and resulting disease burden in Arab countries. Summary: We performed 2 separate analyses in 2 similar populations of patients with noncardioembolic ischemic stroke. This first involved 3,635 patients in the Outcomes in Patients with TIA and Cerebrovascular disease (OPTIC) registry (followed for 2 years), with baseline collection of the usual risk factors and 5 socioeconomic variables (unemployment status, residence in rural area, living in fully serviced accommodation, no health-insurance coverage, and low educational level). The second involved patients in the PERFORM trial (n = 19,100 followed up for 2 years), with baseline collection of the usual risk factors and 1 socioeconomic variable (low educational level). The primary outcome was a composite of nonfatal stroke, nonfatal myocardial infarction, or cardiovascular death. Stroke risk factors were more prevalent in patients in Arab countries. The incidence of major cardiovascular events (MACE; age- and gender-adjusted) was higher in Arab countries (OPTIC, 18.5 vs. 13.3%; PERFORM, 18.4 vs. 9.7%; both p ≤ 0.0001). These results remained significant after adjustment on risk factors and were attenuated in OPTIC after further adjustment on socioeconomic variables (hazard ratio 1.24; 95% CI 0.98-1.55; p = 0.07). Key Messages: Patients with ischemic stroke living in Arab countries had a lower mean socioeconomic status, a much higher prevalence of diabetes mellitus, and a higher rate of MACE compared with patients from non-Arab countries. This finding is partly explained by a higher prevalence of risk factors and also by a high prevalence of poverty and low educational level.

show abstract

“…The average hospitalization costs are high (2). Furthermore, the morbidity, disability and mortality of heart failure following myocardial infarction severely affects the quality of life of the patient and community health care resources.…”

Section: Introductionmentioning

confidence: 99%

Internal associations and dynamic expression of c-kit and nanog genes in ventricular remodelling induced by adriamycin

Liu

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. The present study aimed to investigate the dynamic expression of the c-kit and nanog genes in rats with left ventricular remodelling induced by adriamycin (ADR), and explore its internal association and mechanism of action. Sprague-Dawley male rats were randomly divided into a normal control group and a heart failure model group. Heart failure was induced by a single intraperitoneal injection of ADR (4 mg/kg) weekly for six weeks. The normal control group was given the same amount of saline. At the eighth week, rat cardiac function was examined to demonstrate the formation of heart failure. The rat hearts were harvested frozen and sectioned, and the expression levels of the nanog and c-kit genes in the myocardial tissue samples were detected using immunohistochemistry, immunofluorescence and reverse transcription-polymerase chain reaction (RT-PCR). Hematoxylin and eosin staining demonstrated various pathological changes in the myocardial cells in the heart failure model group, whereas myocardial infarction was not observed in the normal control group. Immunohistochemistry and immunofluorescence demonstrated that nanog-positive cells were predominantly expressed in the vascular endothelium, with a few myocardial cells and stem cells in normal myocardium. The expression levels of c-kit and nanog in the myocardium of the rats with heart failure decreased significantly. c-kit-positive cells clustered together in the epicardium and its vicinity, and c-kit expression significantly decreased in the myocardium of rats with heart failure, as compared with normal rats. In both groups, some cells co-expressed both the c-kit and nanog genes. The RT-PCR results demonstrated that the expression levels of the two genes in the heart failure model group were significantly lower compared with those in the normal control group (P<0.05).In conclusion, the c-kit-and nanog-positive stem cells decreased in the myocardium of the rats with left ventricular remodelling induced by ADR. Their abnormal expression was significantly correlated with left ventricular remodelling, thereby indicating an internal association (influences of two indexes in the experimental group and control group) between them.

show abstract

Impact of Living and Socioeconomic Characteristics on Cardiovascular Risk in Ischemic Stroke Patients

Abstract: Vascular risk in stroke patients in low- and middle-income countries varies not only with the number of arterial beds involved but also with socioeconomic variables.

Cited by 12 publications

References 32 publications

The Prevalence of Stroke Survivors in Urban Slums in Enugu, Nigeria

The Prevalence of Stroke Survivors in Urban Slums in Enugu, Nigeria

Specificities of Ischemic Stroke Risk Factors in Arab-Speaking Countries

Internal associations and dynamic expression of c-kit and nanog genes in ventricular remodelling induced by adriamycin

Contact Info

Product

Resources

About