Impact of liver fibrosis on prognosis following liver resection for hepatitis B-associated hepatocellular carcinoma

Wang, Q; Fiel, M. Isabel; Blank, Sima; Luan, Wei; Kadri, Hena; Kim, K W; Manizate, Fotini; Rosenblatt, Amir; Labow, Daniel M.; Schwartz, Myron; Hiotis, Spiros P.

doi:10.1038/bjc.2013.352

Cited by 72 publications

(91 citation statements)

References 31 publications

(51 reference statements)

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“…Therefore, improved OS in noncirrhotic HCC patients may not be due to lower recurrence rates, but to the greater reserved function of noncirrhotic livers. The proportion of noncirrhotic patients with HCC among all HCC patients ranges from 7 to 54% depending on the report [26] . In this study, 40.4% of HCCs developed in noncirrhotic livers, which translated to a large amount of surgical data for noncirrhotic patients.…”

Section: Discussionmentioning

confidence: 99%

Less Fibrotic Burden Differently Affects the Long-Term Outcomes of Hepatocellular Carcinoma after Curative Resection

Lee¹,

Choi²,

Kim³

et al. 2017

Oncology

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Background: The clinical features of hepatocellular carcinoma (HCC) differ in patients with and without cirrhosis. Objective: We aimed to investigate the long-term outcomes of noncirrhotic HCC patients after curative resection. Methods: We retrospectively examined 649 consecutive patients with HCC who underwent curative resection from 1996 to 2012; 387 (59.6%) were cirrhotic and 262 (40.4%) were noncirrhotic. Results: The mean age was 54.7 years, and 511 (78.7%) of the study participants were men. The most common cause of HCC was hepatitis B virus (n = 419, 64.6%). Noncirrhotic tumors were larger and more advanced than cirrhotic tumors. However, the noncirrhotic group showed better disease-free survival (DFS) and overall survival (OS) after resection than the cirrhotic group (median 64.0 vs. 56.0 months for OS and 48.0 vs. 31.0 months for DFS, p < 0.05). The predictors for HCC recurrence were cirrhosis, tumor number, portal vein invasion, and major surgery. Conclusions: Noncirrhotic HCC showed better DFS and OS after resection than cirrhotic HCC, although noncirrhotic HCC presented more aggressively.

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Section: Discussionmentioning

confidence: 99%

Less Fibrotic Burden Differently Affects the Long-Term Outcomes of Hepatocellular Carcinoma after Curative Resection

Lee¹,

Choi²,

Kim³

et al. 2017

Oncology

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“…Hepatic fibrosis is considered as a wound-healing response to chronic liver injury, which may result in liver cirrhosis and HCC, thus significantly correlated with prognosis of HCC [23,24]. The extent of hepatic fibrosis has usually been evaluated by histological exanimation.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Preoperative Liver Stiffness Measurements in Primary HBV-Positive Hepatocellular Carcinoma

Chen

Zhang

et al. 2017

Future Oncol.

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Aim: To analyze clinical significance of preoperative liver stiffness measurement (LSM) by FibroScan in postcurative resection hepatitis B virus (HBV) related hepatocellular carcinoma (HCC). Patients & methods:A total of 263 patients underwent preoperative LSM and curative operation for primary HBV-positive HCC were enrolled. The correlation between preoperative LSM and survival was analyzed. Results: All patients were stratified into two groups using the optimal cut-off value (13.2 kPa) of LSM using the receiveroperating characteristic. Patients with an LSM ≥13.2 kPa had poorer overall survival (median, 61.3 vs 48.2 months, hazard ratio: 0.15; p = 0.009) and recurrence-free survival (median, 60.4 vs 47.0 months; hazard ratio: 0.32; p = 0.011) than patients with an LSM <13.2 kPa and LSM also have been confirmed as independent predictor for survival for HCC. Discussion: This could potentially guide patient stratification and individualized treatment. Conclusion: Preoperative LSM can be considered as an independent prognostic factor for HBV-positive HCC after curative resection.

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“…Most of Chinese liver cancer patients have a chronic B-related hepatitis history, among whom more than a third are diagnosed of cirrhosis [9]. So, China is located in the high area of primary liver cancer, the incidence has been increasing significantly in recent years [10].…”

Section: Discussionmentioning

confidence: 99%

Therapy Response of Chinese Herbal Medicine in Advanced Liver Cancer: A Retrospective Observational Clinical Trial

Lv¹,

Zhu²,

Wan³

et al. 2016

JPP

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Aiming at starting the ball rolling and contributing humble effort to promote CTM (Chinese traditional medicine), we performed the present study to assess the therapy response of Chinese herbal decoction compared to conventional therapy on critical ill patients of advanced liver cancer. A total of 6 patients (1 female and 5 males) with histologically confirmed liver cancer were included in this retrospective observational clinical trial. We administered Chinese medicine (Gan Decoction, mixed with a variety of effective herbal components) to help them to recover from poor condition. In the meantime, conventional treatment of surgical resection and artery catheterization chemotherapy was applied in cases compared. In 3 cases of CTM combined treatment, the tumor marker level decreased. Residual intrahepatic metastatic sites reduced according to ultrasonography/CT imaging, and the patients felt free from the complaint of abdominal discomfort. The quality of life has been improved, we managed to have prolonged the PFS (Progression-Free-Survival) and TTP (Time-to-Progression) from the onset to date. While in 3 cases with conventional treatment only of surgical resection and artery catheterization chemotherapy, we were not able to decrease the level of tumor marker, metastatic lesions increased according to ultrasonography/CT imaging, and the patient's condition worsen more. We failed in having prolonged the PFS and TTP in the compared cases of conventional treatment only. The retrospective clinical study showed no OS (overall survival) benefit for liver cancer patients treated with Gan Decoction, while the QOL (quality of life) evaluation seemed to predict survival better. Chinese herbs might be an additional choice with its better benefits and tolerability in the treatment of primary liver cancer.

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Impact of liver fibrosis on prognosis following liver resection for hepatitis B-associated hepatocellular carcinoma

Cited by 72 publications

References 31 publications

Less Fibrotic Burden Differently Affects the Long-Term Outcomes of Hepatocellular Carcinoma after Curative Resection

Less Fibrotic Burden Differently Affects the Long-Term Outcomes of Hepatocellular Carcinoma after Curative Resection

Clinical Significance of Preoperative Liver Stiffness Measurements in Primary HBV-Positive Hepatocellular Carcinoma

Therapy Response of Chinese Herbal Medicine in Advanced Liver Cancer: A Retrospective Observational Clinical Trial

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