Impact of lingual gyrus volume on antidepressant response and neurocognitive functions in Major Depressive Disorder: A voxel-based morphometry study

Imaging predictors of remission to anti-depressant medications in major depressive disorder

“…Other research, which have not satisfied inclusion criteria for this review, have similarly conflicting findings, including better ADM responses with bigger left hippocampi (Samann et al, 2013), or establishing no relationship between hippocampal size and response (Toki et al, 2014). Although two studies associated a smaller right superior frontal gyrus with remitters (Costafreda et al, 2009;Li et al, 2010), Jung et al (2014) showed significantly smaller volumes in patients who did not respond to 8 weeks of ADM, compared to healthy controls (Jung et al, 2014). More consistent findings have been seen with the anterior and posterior cingulate cortices, with larger sizes of both structures predicting remission (Costafreda et al, 2009;Gunning et al, 2009;Jarnum et al, 2011).…”

Detecting Neuroimaging Biomarkers for Depression: A Meta-analysis of Multivariate Pattern Recognition Studies

“…Multiple studies reported changes in brain structure (77) and function (82)(83)(84) following chronic antidepressant treatment. If such effects are present in neuroimagingbased classification experiments, the brain patterns identified might be associated with drugeffects rather than with effects specific to the pathology of depression.…”

Molecular, Functional, and Structural Imaging of Major Depressive Disorder

“…Other VBM studies have also found structural abnormalities in regions including the insula, thalamus, and hippocampus in MDD patients [28,[35][36][37][38][39][40][41][42][43]. The anterior insula connects to the inferior frontal cortex and to the ACC [44].…”