Impact of ligating gonadal or adrenal collateral veins with the left renal vein on renal function and histology in right-nephrectomized rats

Yücel, Tayfun; Ekiz, Feza; Gürdal, Sibel Özkan; Yavuz, Hasan; Gönüllü, Doğan; Köksoy, Ferda Nihat; Şit, Mustafa; Igdem, Aysenur Akyildiz; Sahan, Elife

doi:10.1016/j.ijsu.2009.05.006

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…In other words, a small reduction in diameter can have a large effect on pressure as well as on the health and viability of upstream tissue. In a previous rodent study, the left renal vein was ligated leading to increased flow through collateral vessels; mortality, though, increased when important collateral vessels were not preserved [17]. The overall BP change in the stenosed group was about 10 mmHg higher in both systolic and diastolic BP than in sham controls.…”

Section: Discussionmentioning

confidence: 91%

Toward Automation of the Supine Pressor Test for Preeclampsia

Qureshi

Anderson

et al. 2019

Journal of Engineering and Science in Medical Diagnostics and Therapy

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Preeclampsia leads to increased risk of morbidity and mortality for both mother and fetus. Most previous studies have largely neglected mechanical compression of the left renal vein by the gravid uterus as a potential mechanism. In this study, we first used a murine model to investigate the pathophysiology of left renal vein constriction. The results indicate that prolonged renal vein stenosis after 14 days can cause renal necrosis and an increase in blood pressure (BP) of roughly 30 mmHg. The second part of this study aimed to automate a diagnostic tool, known as the supine pressor test (SPT), to enable pregnant women to assess their preeclampsia development risk. A positive SPT has been previously defined as an increase of at least 20 mmHg in diastolic BP when switching between left lateral recumbent and supine positions. The results from this study established a baseline BP increase between the two body positions in nonpregnant women and demonstrated the feasibility of an autonomous SPT in pregnant women. Our results demonstrate that there is a baseline increase in BP of roughly 10-14 mmHg and that pregnant women can autonomously perform the SPT. Overall, this work in both rodents and humans suggests that (1) stenosis of the left renal vein in mice leads to elevation in BP and acute renal failure, (2) nonpregnant women experience a baseline increase in BP when they shift from left lateral recumbent to supine position, and (3) the SPT can be automated and used autonomously.

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Section: Discussionmentioning

confidence: 91%

Toward Automation of the Supine Pressor Test for Preeclampsia

Qureshi

Anderson

et al. 2019

Journal of Engineering and Science in Medical Diagnostics and Therapy

View full text Add to dashboard Cite

show abstract

“…In an animal study with rats, division of both the left renal vein and adrenal vein resulted in acceptable renal function and histology. On the other hand, the gonadal vein should be preserved as a major draining channel (25). In a clinical study with patients undergoing LRVD as an adjunct to aortic surgery, postoperative spermatic venography demonstrated collateral drainage through various retroperitoneal veins in most cases (24).…”

Section: Discussionmentioning

confidence: 99%

CT findings after left renal vein division during abdominal aortic surgery

et al. 2020

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Background The rationale behind left renal vein division (LRVD) is the assumption that adequate collateral draining channels will develop. Purpose To describe computed tomography (CT) findings after LRVD during aortic surgery. Material and Methods Among 61 consecutive patients who underwent LRVD during aneurysm repair or revascularization for aortic occlusive disease between January 2003 and December 2017, 51 patients (40 men, mean age 71.4 ± 8.4 years) were enrolled. Contrast-enhanced CT images were analyzed to evaluate collateral drainage, patency, left renal vein diameter, and left renal parenchymal thickness. A total of 115 radiologic reports were reviewed to check whether these findings were accurately mentioned. Results The median time period of the first postoperative follow-up CT was 36 days (range 7–1351 days). The gonadal vein (n = 47) was the most common collateral draining channel, followed by the retroperitoneal veins (n = 42) and adrenal vein (n = 33). Thrombosis occurred in five patients between postoperative days 7 and 17 in the remnant renal vein (n = 3), remnant renal vein plus gonadal and adrenal veins (n = 1), and gonadal vein (n = 1). There was a significant decrease in renal vein diameter (–0.48 ± 2.12 mm, P = 0.006). There was no significant difference in parenchymal thickness (−0.25 ± 1.27 mm, P = 0.193). Neither LRVD nor any associated findings were correctly stated on radiologic reports. Conclusion Postoperative contrast-enhanced CT can delineate collateral draining channels and complications following LRVD. However, these findings tend to be either missed or misinterpreted.

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Impact of ligating gonadal or adrenal collateral veins with the left renal vein on renal function and histology in right-nephrectomized rats

Abstract: In right-nephrectomized rats, the LRV near the IVC and the adrenal collateral can be ligated, while the gonadal collateral should be preserved.

Cited by 2 publications

References 22 publications

Toward Automation of the Supine Pressor Test for Preeclampsia

Toward Automation of the Supine Pressor Test for Preeclampsia

CT findings after left renal vein division during abdominal aortic surgery

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