Impact of left ventricular hypertrophy on clinical outcomes in patients with dialysis: a single-center study in Japan

Nakayama, Takafumi; Yamamoto, Junki; Ozeki, Toshikazu; Yasuda, Kaoru; Yamazaki, Chikao; Ito, Tsuyoshi; Goto, Toshihiko; Maruyama, Shoichi; Morozumi, Kunio; Seo, Yoshihiro

doi:10.1007/s10396-022-01197-4

Cited by 2 publications

(2 citation statements)

References 32 publications

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“…The initial time-point for the survival analysis was the date of baseline echocardiography (prescheduled routine echocardiography). Cox proportional hazards analyses were performed using ASA, AVCS, MVCS, and other echocardiographic and clinical variables, including parameters that are considered risk factors for the primary endpoint [2,23,[27][28][29][30][31][32][33]. Regarding the incidence of the primary endpoint, up to five variables that achieved P-values < 0.05 in the univariable analyses were available in the multivariable Cox proportional hazards analyses.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, 306 patients were eligible for analysis in the current study (Fig 1). This study was a sub-analysis of a previous study investigating the impact of LV hypertrophy in hemodialysis patients [23]. The data were accessed for research purposes between November 6th, 2019, and September 15th, 2023, and the authors accessed information that could identify individual participants during data collection.…”

Section: Study Populationmentioning

confidence: 99%

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Impact of an angulated aorto-septal relationship on cardio-cerebrovascular outcomes in patients undergoing hemodialysis

Nakayama,

Yamamoto,

Ozeki

et al. 2024

PLoS ONE

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Aortic and valvular calcification are well-known risk factors for cardio-cerebrovascular events in patients undergoing hemodialysis. We investigated the clinical impact of an angulated aorto-septal angle as a result of aortic elongation due to aortic calcification on cardio-cerebrovascular outcomes in patients undergoing hemodialysis. We investigated 306 patients (mean age 65.4 years, 68% male) who underwent pre-scheduled routine echocardiography between April and September 2018. The angle between the anterior wall of the aorta and the ventricular septal surface (ASA) was quantified. We determined aortic and mitral valve calcification scores based on calcified cardiac changes; the aortic and mitral valve scores ranged between 0–9 and 0–6, respectively. The primary endpoint was a composite including cardio-cerebrovascular events and cardio-cerebrovascular death. The mean duration of dialysis among the patients in this analysis was 9.6 years. The primary endpoint was observed in 54 patients during the observational period (median 1095 days). Multivariable Cox proportional hazards analyses identified left ventricular ejection fraction (per 10% increase: hazard ratio [HR] 0.67; 95% confidential interval [CI] 0.53–0.84, P = 0.001), left ventricular mass index (per 10 g/m2 increase: HR 1.14; 95% CI 1.05–1.24, P = 0.001), ASA (per 10 degree increase: HR 0.69; 95% CI 0.54–0.88; P = 0.003), and aortic valve calcification score (HR 1.15; 95% CI 1.04–1.26, P = 0.005) as independent determinants of the primary endpoint. Kaplan-Meier analysis showed a higher incidence of the primary endpoint in patients with ASA <119.4 degrees than those with ASA ≥119.4 degrees (Log-rank P < 0.001). An angulated aorto-septal angle is an independent risk factor for cardio-cerebrovascular events and cardio-cerebrovascular death in patients undergoing hemodialysis.

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Section: Discussionmentioning

confidence: 99%

Section: Study Populationmentioning

confidence: 99%

Impact of an angulated aorto-septal relationship on cardio-cerebrovascular outcomes in patients undergoing hemodialysis

Nakayama,

Yamamoto,

Ozeki

et al. 2024

PLoS ONE

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Non-A Blood Type Is a Risk Factor for Poor Cardio-Cerebrovascular Outcomes in Patients Undergoing Dialysis

et al. 2023

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The clinical impact of ABO blood type on cardio-cerebrovascular outcomes in patients undergoing dialysis has not been clarified. A total of 365 hemodialysis patients participated in the current study. The primary endpoint was defined as a composite including cardio-cerebrovascular events and cardio-cerebrovascular death. The primary endpoint was observed in 73 patients during a median follow-up period of 1182 days, including 16/149 (11%) with blood type A, 22/81 (27%) with blood type B, 26/99 (26%) with blood type O, and 9/36 (25%) with blood type AB. At baseline, no difference was found in the echocardiographic parameters. Multivariable Cox regression analyses revealed that blood type (type A vs. non-A type; hazard ratio (HR): 0.46, 95% confidence interval (95% CI): 0.26–0.81, p = 0.007), age (per 10-year increase; HR: 1.47, 95% CI: 1.18–1.84), antiplatelet or anticoagulation therapy (HR: 1.91, 95% CI: 1.07–3.41), LVEF (per 10% increase; HR: 0.78, 95% CI: 0.63–0.96), and LV mass index (per 10 g/m2 increase; HR: 1.07, 95% CI: 1.01–1.13) were the independent determinants of the primary endpoint. Kaplan–Meier curves also showed a higher incidence of the primary endpoint in the non-A type than type A (Log-rank p = 0.001). Dialysis patients with blood type A developed cardio-cerebrovascular events more frequently than non-A type patients.

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Impact of left ventricular hypertrophy on clinical outcomes in patients with dialysis: a single-center study in Japan

Cited by 2 publications

References 32 publications

Impact of an angulated aorto-septal relationship on cardio-cerebrovascular outcomes in patients undergoing hemodialysis

Impact of an angulated aorto-septal relationship on cardio-cerebrovascular outcomes in patients undergoing hemodialysis

Non-A Blood Type Is a Risk Factor for Poor Cardio-Cerebrovascular Outcomes in Patients Undergoing Dialysis

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