Impact of Left Ventricular Dysfunction on Renal Transplant Survival: Study of Paired Kidneys From the Same Donor

Monte, Esther González; Mora, M.T.; Polanco, Natalia; Morales, Enrique; Gutiérrez, Eduardo; Molina, María; Sevillano, Ángel; Hernández, Eduardo; Praga, Manuel; Andrés, Amado

doi:10.1016/j.transproceed.2014.11.013

Cited by 8 publications

(4 citation statements)

References 7 publications

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“…As renal graft survival is the main determinant of successful renal transplantation, the predictors for renal graft survival are well studied. Another study performed by Gonzalez Monte et al 7 examined the impact of pretransplant LV systolic function on renal transplant survival. They found that LV systolic dysfunction defined as a LVEF of less than 50% is associated with poor graft survival and renal function.…”

mentioning

confidence: 99%

LV remodelling after renal transplantation: future directions

Hung

2015

Heart

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mentioning

confidence: 99%

LV remodelling after renal transplantation: future directions

Hung

2015

Heart

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“…One month after surgery the patient had creatinine level of 1.9 mg/dL with normal Qmax and PVR of 33 cc/s and 35.4 cc, respectively. This proves that patients with decreased LVEF had increased risk for delayed graft and worse long-term graft function 31 .…”

Section: Discussionmentioning

confidence: 68%

Voiding profile in recipients post renal transplant: A prospective observational study

et al. 2019

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Background: Renal transplantation (RTX) is thought to have high survival rates. However, patients with long-term dialysis have decreased bladder function due to disuse. High urine production after RTX surgery might cause patients to have urinary symptoms, thus decreasing their quality of life. The aim of this study was to evaluate voiding characteristics of patients after RTX surgery. Methods: All patients were diagnosed with chronic kidney disease (CKD) and underwent kidney transplantation from a living donor. Anthropometric parameters, physical examinations, cause of CKD, daily urine production, types and duration of dialysis, and basic laboratory examination were collected before transplant surgery. Post-operative examinations included laboratory examination, international prostate symptom score (IPSS; for male patients only), overactive bladder symptom score (OABSS), uroflowmetry, and post void residue (PVR). Results: 71 patients were evaluated with a mean age of 46 ± 17.9 years, with male and female ratio of 52:19. Significant negative correlation was seen between duration of dialysis and daily urine production (r: -0.68, p<0.01). Majority of patients had a maximum flow rate of >15 cc/s (70.4 %) with average flow of 22 ± 9.8 cc/s. The majority of patients had PVR <100 cc (91.5%) with median PVR of 33.5 cc (range, 2.3 – 142 cc). IPSS result showed that frequency [2 (0 – 5)] and nocturia [2 (0 – 5)] are the main problem in these patients (n = 52). OABSS questionnaire also showed that frequency (OABSS 1; score 1 [1-2]) and nocturia (OABSS 2; score 2 [0-3]) was the main symptoms reported by patients. Conclusion: After RTX, the majority of patients experienced urinary frequency and nocturia problems due to various causes such as increased daytime and nighttime urine production, urinary tract infection, changes in bladder capacity (both small and large), and a decrease in bladder compliance.

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“…43,44 Also, systolic dysfunction in the renal transplant recipient is associated with a greater delay in graft function and worse graft survival with poor renal function. 45 Wali et al did not report a change in volumetric and structural parameters of left ventricle. 39 Improvement in ejection fraction in all reported studies could have been due to hemodynamic alterations in preload, correction of anemia, and normalization of parathormone level after kidney transplantation.…”

Section: End -S Tag E Renal D Is E a S E And He Art Failurementioning

confidence: 94%

“…However, improvement may be unpredictable and suboptimum hemodynamics could compromise graft function . Also, systolic dysfunction in the renal transplant recipient is associated with a greater delay in graft function and worse graft survival with poor renal function . Wali et al did not report a change in volumetric and structural parameters of left ventricle .…”

Section: End‐stage Renal Disease and Heart Failurementioning

confidence: 95%

Kidney transplantation and cardiomyopathy: Concepts and controversies in clinical decision‐making

Jha

Lata

2020

Clinical Transplantation

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Increasing comorbidities and an aging population have led to a tremendous increase in the burden of both kidney and cardiac dysfunction. Concomitant cardiomyopathy exposes the patients with kidney disease to further physiological, hemodynamic, and pathologic alterations. Kidney transplantation imposes lesser anesthetic and surgical complexities compared to another solid organ transplant. The surgical decision‐making remains an unsettled issue in these conditions. The surgical choices, techniques, and sequences in kidney transplant and cardiac surgery depend on the pathophysiological perturbations and perioperative outcomes. The absence of randomized controlled trials eludes us from suggesting definite management protocol in patients with end‐stage kidney disease with cardiomyopathy. Nevertheless, in this review, we extracted data from published literature to understand the pathophysiologic interactions between end‐stage renal diseases with cardiomyopathy and also proposed the management algorithm in this challenging scenario. The proposed management algorithm would ensure consensus across all stakeholders involved in decision‐making. Our simplistic evidence‐based approach would augur future randomized trials and would further ensure refinement in our management approach after the emergence of more definitive evidence.

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Impact of Left Ventricular Dysfunction on Renal Transplant Survival: Study of Paired Kidneys From the Same Donor

Cited by 8 publications

References 7 publications

LV remodelling after renal transplantation: future directions

LV remodelling after renal transplantation: future directions

Voiding profile in recipients post renal transplant: A prospective observational study

Kidney transplantation and cardiomyopathy: Concepts and controversies in clinical decision‐making

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