Impact of lead toxicity on male rat reproduction at “Hormonal and Histopathological Levels”

El‐Sayed, Yasser S.; El-Neweshy, M. S.

doi:10.1016/j.toxlet.2009.06.510

Cited by 8 publications

(8 citation statements)

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“…However, semen analysis revealed that sperm motility decreased in the PbAc group and that the percentage of dead and abnormal sperm increased. These results were similar to those of El‐Sayed and El‐Neweshy (2010). It could be said that these effects of Pb on semen are due to the delay in the release of immature spermatogenic cells from seminiferous tubules as well as slowing of spermiation during spermatogenesis (Alves et al., 2014).…”

Section: Discussionsupporting

confidence: 91%

Chrysin protects against testicular toxicity caused by lead acetate in rats with its antioxidant, anti‐inflammatory, and antiapoptotic properties

et al. 2020

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In the present study, the protective effects of chrysin (CHR) against testicular damage caused by lead acetate (PbAc) were examined. In this way, 30 min after rats were given 25 and 50 mg/kg/b.w CHR orally for seven consecutive days, 30 mg/kg/b.w PbAc was administered orally. In biochemical analysis of testicular tissue, it was found that PbAc-reduced antioxidant parameters [glutathione peroxidase (GPx), glu

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Section: Discussionsupporting

confidence: 91%

Chrysin protects against testicular toxicity caused by lead acetate in rats with its antioxidant, anti‐inflammatory, and antiapoptotic properties

et al. 2020

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“…Similar results were also observed in rats by Allouche et al (2009) andEl-Sayed andEl-Neweshy (2010). The absence of Pb effect on body weight gain may be explained by the absence of general toxicity.…”

Section: Discussionsupporting

confidence: 87%

“…Treatment of rats with Pb for 35 days had no effect on body weight gain and relative testes weight when compared with the control group. Similar results were also observed in rats by Allouche et al (2009) and El-Sayed and El-Neweshy (2010). The absence of Pb effect on body weight gain may be explained by the absence of general toxicity.…”

Section: Discussionsupporting

confidence: 85%

Thymoquinone supplementation ameliorates lead-induced testis function impairment in adult rats

Mabrouk¹,

Cheikh

2014

Toxicol Ind Health

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This study was realized to investigate the possible beneficial effect of thymoquinone (TQ), the major active component of volatile oil of Nigella sativa seeds, against lead (Pb)-induced inhibition of rat testicular functions. Adult rats were randomized into four groups: a control group receiving no treatment; a Pb group exposed to 2000 parts per million (ppm) of Pb acetate in drinking water; a Pb-TQ group co-treated with Pb (as in Pb group) plus TQ (5 mg/kg body weight (b.w.)/day, per orally (p.o.)); and a TQ group receiving TQ (5 mg/kg b.w./day, p.o.). All treatments were for 5 weeks. No significant differences were observed for the body weight gain or for relative testes weight among the four groups of animals. Testicular Pb content significantly increased in metal-intoxicated rats compared with that in control rats. TQ supplementation had no effect on this testicular Pb accumulation. Interestingly, when coadministrated with Pb, TQ significantly improved the low plasma testosterone level and the decreased epididymal sperm count caused by Pb. In conclusion, the results suggest, for the first time, that TQ protects against Pb-induced impairment of testicular steroidogenic and spermatogenic functions. This study will open new perspectives for the clinical use of TQ in Pb intoxication.

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“…Many studies indicated that Pb exerts its effects on testis both directly or indirectly. Direct effects include interference of Pb with testicular Sertoli cells thereby altering sperm production and quality (Wadi and Ahmad, 1999), and indirectly, Pb interferes with the hypothalamo-pituitary axis thereby altering circulating follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels (EI-Sayed and EI-Neweshy, 2010). Pb also interferes with epididymal functions thereby causing asthenospermia, oligospermia, and teratospermia (Morán-Martínez et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

The protective effects of zinc in lead-induced testicular and epididymal toxicity in Wistar rats

et al. 2016

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The aim of this study was to investigate the beneficial effects of zinc (Zn) in preventing lead (Pb)-induced reproductive toxicity in Wistar rats. The rats were divided into four groups, namely, control group, Pb group, Zn group, and Pb + Zn group. Animals were exposed to Pb (819 mg of Pb/L) or Zn (71 mg of Zn/L) or both through drinking water for 65 days. Rats exposed to Pb showed decreased weights of testes and accessory sex organs. Significant decrease in the testicular daily sperm production, epididymal sperm count, motility, viability, and number of hypoosmotic tail coiled sperm was observed in Pb-exposed rats. Testicular 3β- and 17β-hydroxysteroid dehydrogenase activity levels and circulatory testosterone levels were also decreased significantly in Pb-exposed rats. A significant increase in the lipid peroxidation products with a significant decrease in the activities of catalase and superoxide dismutase were observed in the testes and epididymis of Pb-exposed rats. Moreover, the testicular architecture showed lumens devoid of sperm in Pb-exposed rats. Supplementation of Zn mitigated Pb-induced oxidative stress and restored the spermatogenesis and steroidogenesis in Pb-exposed rats. In conclusion, cotreatment of Zn is effective for recovering suppressed spermatogenesis, steroidogenesis, elevated oxidative status, and histological damage in the testis of rats treated with Pb.

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Impact of lead toxicity on male rat reproduction at “Hormonal and Histopathological Levels”

Cited by 8 publications

References 0 publications

Chrysin protects against testicular toxicity caused by lead acetate in rats with its antioxidant, anti‐inflammatory, and antiapoptotic properties

Chrysin protects against testicular toxicity caused by lead acetate in rats with its antioxidant, anti‐inflammatory, and antiapoptotic properties

Thymoquinone supplementation ameliorates lead-induced testis function impairment in adult rats

The protective effects of zinc in lead-induced testicular and epididymal toxicity in Wistar rats

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