Impact of lead toxicity on male rat reproduction at “hormonal and histopathological levels”

El‐Sayed, Yasser S.; El-Neweshy, M. S.

doi:10.1080/02772240902984453

Cited by 41 publications

(24 citation statements)

References 28 publications

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“…Heavy metals have also been related to cellular injury, metabolic disorders, and DNA and proteins damage, that may lead to cell and reproductive cycle disturbance, carcinogenesis, or apoptosis (Gerber et al, 1980;Ronis et al, 1996;Wang and Shi, 2001;Tchounwou et al, 2004Tchounwou et al, , 2012Beyersmann and Hartwig, 2008;El-Sayed and El-Neweshy, 2010;Obiakor et al, 2010;Ebrahimi and Taherianfard, 2011). Although in invertebrates the number of these studies is lower, and these organisms present different susceptibility to pollutants, several authors have suggested similar effects and mechanisms than that of vertebrates and have propose them as models in endocrine disruption research (Viarengo et al, 1990;Bolognesi et al, 1999;Matozzo et al, 2001;DeFur, 2004;Porte et al, 2006;Zhou et al, 2009;Fatima et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…However, there are scarce studies about cellular disorders and pathologies of this process in invertebrates, contrarily to in vertebrates. In the latter, the testis is a known target of PAHs and metals toxicity, experiencing disruption of spermatogenesis, degeneration, and loss of germ cell, and testicular atrophy (Ronis et al, 1996;Adhikari et al, 2001;Creasy and Foster, 2002;Dietrich and Krieger, 2009;El-Sayed and El-Neweshy, 2010;Mathur et al, 2010;Ebrahimi and Taherianfard, 2011;Creasy et al, 2012;Chandel and Jain, 2014).…”

Section: Gonadal and Histological Disordersmentioning

confidence: 99%

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Gonadal Histopathological Disorders in Mytilus galloprovincialis Male Exposed to Tars Used in Mussel Farms

et al. 2019

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Polycyclic aromatic hydrocarbons (PAHs) and trace metals are pollutants widely distributed in the marine environment with toxic effects on live organisms, but few laboratory studies have proved their causal relationship with histopathologic alterations from invertebrates. We analyse the histopathologic effects of a tar mixture used in mussel farms on the gonad of male mussels. Mussels were exposed to water-accommodated fractions from different sub-lethal concentrations of that tar mixture during different times. The accumulation of PAHs and metals in mussels was quantified in each one tar exposure condition, and a comparative histological and morphometric analysis of the male gonad was performed, as well as of the gametogenic disorders and the cellular pathologies induced. Spermatogenesis disruption and alterations of somatic and germinal cells were observed as a direct effect of treatment. The pathologies observed followed an increasing malignity sequence depending on dose and exposure time: spawning induction; arrest of spermatogenesis and spermiogenesis; suppression of immune response; dysplasia of Sertoli and connective cells and finally, severe disorders of germinal cells. We demonstrate for the first time that tar used in waterproofing of floating rafts from the mussel farms causes severe effects on male mussel gonad, constituting a direct risk to the health of these organisms, affecting gametogenesis, quality of gametes and, ultimately, the sustainability of this resource and their quality for human consumption. Moreover, we propose the pathologies described in mussel as biomarkers of marine pollution and the mussel gonad as study model of testicular toxicity mechanisms in male reproduction.

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Section: Discussionmentioning

confidence: 99%

Section: Gonadal and Histological Disordersmentioning

confidence: 99%

Gonadal Histopathological Disorders in Mytilus galloprovincialis Male Exposed to Tars Used in Mussel Farms

et al. 2019

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“…Lead intoxication is one of the most common forms of metal intoxication. Numerous studies in humans and animals indicate that high levels of lead exposure can promote renal, nervous, hepatic, hematological and reproductive disorders (Ashry et al, 2010;El-Sayed and El-Neweshy, 2010;Flora et al, 2008). However, the effects of chronic low-level lead exposure have not been well-studied.…”

Section: Discussionmentioning

confidence: 99%

Hepatic fibrogenesis and transforming growth factor/Smad signaling activation in rats chronically exposed to low doses of lead

Aguilar

Honoré

Genta

et al. 2013

J of Applied Toxicology

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Lead is an important heavy metal pollutant in the environment. The nervous system, kidney and liver are the most susceptible organs to lead deposition, showing that this pollutant has no single target system. To examine the cellular and molecular mechanisms involved in their pathobiology of chronic lead at low-dose exposure in the liver, male Wistar rats were exposed to 0.06% lead acetate in drinking water every day for 4 months. At the end of the study, hepatic metal accumulation, morphology and function were examined. Immunochemical staining and Western blot analysis were performed to detect extracellular matrix proteins, α-smooth muscle actin and transforming growth factor (TGF)β1/Smad pathway expression. Results showed increased laminin, collagen IV and fibronectin, located at the perisinusoidal space. Phenotypic transformation of hepatic stellate cells into myofibroblast-like cells was evidenced at the ultrastructural level and a significant expression of α-smooth muscle actin in Disse’s space was observed. These findings were associated with a marked increase in TGFβ1/Smad2/3 signaling. Our data suggest that, chronically, exposure to low levels of lead could trigger the onset of a hepatic fibrogenic process through upregulated TGFβ1/Smad signaling.

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“…The doses for lead acetate were selected on the basis of previously published studies (Ronis et al ., ; El‐Sayed & El‐Neweshy, ).…”

Section: Methodsmentioning

confidence: 99%

Protective effects ofFumaria parvifloraL. on lead-induced testicular toxicity in male rats

2013

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In recent years, the clinical importance of herbal drugs has received considerable attention in reducing free radical-induced tissue injury. Oxidative stress has been proposed as a possible mechanism involved in lead toxicity that causes reproductive system failure in both human and animals. Fumaria parviflora L., a traditional herb, has been used to cure various ailments in Persian folk medicine. This study was carried out to investigate whether ethanolic extract of F. parviflora leaves could protect the male rats against lead-induced testicular oxidative stress. Adult Wistar rats were treated with 0.1% lead acetate in drinking water with or without 200 mg kg day(-1) F. parviflora extract via gavage for 70 days. Lead acetate treatment resulted in significant reduction in testis weight, seminiferous tubules diameter, epididymal sperm count, serum testosterone level, testicular content of superoxide dismutase (SOD) and glutathione peroxidase (GPx). Moreover, significant elevation was observed in content of malondialdehyde (MDA) in lead-treated rats. However, co-administration of F. parviflora extract showed a significant increase in selected reproductive parameters in lead-treated rats. The results indicated that ethanolic extract of F. parviflora leaves has a potential to restore the suppressed reproduction associated with lead exposure and prevented lead-induced testicular toxicity in male Wistar rats.

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Impact of lead toxicity on male rat reproduction at “hormonal and histopathological levels”

Cited by 41 publications

References 28 publications

Gonadal Histopathological Disorders in Mytilus galloprovincialis Male Exposed to Tars Used in Mussel Farms

Gonadal Histopathological Disorders in Mytilus galloprovincialis Male Exposed to Tars Used in Mussel Farms

Hepatic fibrogenesis and transforming growth factor/Smad signaling activation in rats chronically exposed to low doses of lead

Protective effects ofFumaria parvifloraL. on lead-induced testicular toxicity in male rats

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