Impact of Lead Sub-Chronic Toxicity on Recognition Memory and Motor Activity of Wistar Rat

Azzaoui, Fatima-Zahra; Ahami, Ahmed Omar Touhami; Khadmaoui, Abderrazzak

doi:10.3923/pjbs.2009.173.177

Cited by 15 publications

(13 citation statements)

References 5 publications

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“…Introduction) reported deficits in object recognition (Azzaoui et al, 2009) and in spatial memory (Kasten-Jolly et al, 2012), similar to those found in the current study. Object recognition and spatial memory are sub-served by brain regions that overlap olfactory recognition memory pathways including the prefrontal, entorhinal and perirhinal cortices, and the hippocampus/dentate gyrus (Jesseberger et al, 2009; Parron et al, 2006; Rinaldi et al, 2007; Winters and Bussey, 2005).…”

Section: Discussionsupporting

confidence: 90%

“…For example, in adulthood, BALB/c mice chronically exposed to 20 ppm lead acetate delivered in dam’s drinking water had diminished memory (object recognition memory task) as compared to controls (Azzaoui et al, 2009). In a similar study, as compared to controls, adult Wistar rats chronically exposed to 20 ppm of lead in dam’s drinking water had diminished spatial memory (water maze) (Kasten-Jolly et al, 2012) (blood lead levels were not reported).…”

Section: Introductionmentioning

confidence: 99%

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Olfactory recognition memory is disrupted in young mice with chronic low-level lead exposure

2015

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Chronic developmental lead exposure yielding very low blood lead burden is an unresolved child public health problem. Few studies have attempted to model neurobehavioral changes in young animals following very low level exposure, and studies are needed to identify tests that are sensitive to the neurobehavioral changes that may occur. Mechanisms of action are not yet known however results have suggested that hippocampus/dentate gyrus may be uniquely vulnerable to early chronic low-level lead exposure. This study examined the sensitivity of a novel odor recognition task to differences in pre-adolescent C57BL/6J mice chronically exposed from birth to PND 28, to 0 ppm (control), 30 ppm (low-dose), or 330 ppm (higher-dose) lead acetate (N = 33). Blood lead levels (BLLs) determined by ICP-MS ranged from 0.02 to 20.31 µg/dL. Generalized linear mixed model analyses with litter as a random effect showed a significant interaction of BLL × sex. As BLLs increased olfactory recognition memory decreased in males. Among females, non-linear effects were observed at lower but not higher levels of lead exposure. The novel odor detection task is sensitive to effects associated with early chronic low-level lead exposure in young C57BL/6J mice.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Olfactory recognition memory is disrupted in young mice with chronic low-level lead exposure

2015

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“…In a study of adult Wistar rats with and without exposure to 20 ppm lead acetate delivered in dams’ drinking water during development, low-level lead-exposed animals had decreased recognition memory (novel object recognition task), and increased exploratory ambulation (open field task) (Azzaoui, Ahami, and Khadmaoui, 2009). In another study of adult Sprague–Dawley rats exposed to 5 and 50 ppm lead acetate delivered in dams’ drinking water, the lowest exposure group had decreased exploratory ambulation on an open field task (Reiter, Anderson, Laskey, and Cahill, 1975) (specific BLL values not reported).…”

Section: Introductionmentioning

confidence: 99%

Early chronic lead exposure reduces exploratory activity in young C57BL/6J mice

Flores-Montoya

Sobin

2014

J of Applied Toxicology

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Research has suggested that chronic low-level lead exposure diminishes neurocognitive function in children. Tests that are sensitive to behavioral effects at lowest levels of lead exposure are needed for the development of animal models. In this study we investigated the effects of chronic low-level lead exposure on exploratory activity (unbaited nose poke task), exploratory ambulation (open field task) and motor coordination (Rotarod task) in pre-adolescent mice. C57BL/6J pups were exposed to 0 ppm (controls), 30 ppm (low-dose) or 230 ppm (high-dose) lead acetate via dams’ drinking water administered from birth to postnatal day 28, to achieve a range of blood lead levels (BLLs) from not detectable to 14.84 μg dl−1). At postnatal day 28, mice completed behavioral testing and were killed (n = 61). BLLs were determined by inductively coupled plasma mass spectrometry. The effects of lead exposure on behavior were tested using generalized linear mixed model analyses with BLL, sex and the interaction as fixed effects, and litter as the random effect. BLL predicted decreased exploratory activity and no threshold of effect was apparent. As BLL increased, nose pokes decreased. The C57BL/6J mouse is a useful model for examining effects of early chronic low-level lead exposure on behavior. In the C57BL/6J mouse, the unbaited nose poke task is sensitive to the effects of early chronic low-level lead exposure. This is the first animal study to show behavioral effects in pre-adolescent lead-exposed mice with BLL below 5 μg dl−1.

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“…In mouse and rodent models, early chronic exposure to Pb resulted in decreased memory, and abnormal motor and exploratory behavior (Azzaoui et al, 2009; Kasten-Jolly et al, 2012; Leasure et al, 2008). The mechanisms by which early chronic exposure to Pb alters brain structure and function have not been identified.…”

Section: Introductionmentioning

confidence: 99%

Microglial disruption in young mice with early chronic lead exposure

et al. 2013

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The mechanisms by which early chronic lead (Pb) exposure alter brain development have not been identified. We examined neuroimmune system effects in C57BL/6J mice with Pb exposure, including levels that may be common among children in lower socioeconomic income environments. Pups were exposed via dams’ drinking water from birth to post-natal day 28 to low, high or no Pb conditions. We compared gene expression of neuroinflammatory markers (study 1); and microglial mean cell body volume and mean cell body number in dentate gyrus, and dentate gyrus volume (study 2). Blood Pb levels in exposed animals at sacrifice (post-natal day 28) ranged from 2.66 to 20.31 μg/dL. Only interleukin-6 (IL6) differed between groups and reductions were dose-dependent. Microglia cell body number also differed between groups and reductions were dose-dependent. As compared with controls, microglia cell body volume was greater but highly variable in only low-dose animals; dentate gyri volumes in low- and high-dose animals were reduced. The results did not support a model of increased neuroinflammation. Instead, early chronic exposure to Pb disrupted microglia via damage to, loss of, or lack of proliferation of microglia in the developing brains of Pb-exposed animals.

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Impact of Lead Sub-Chronic Toxicity on Recognition Memory and Motor Activity of Wistar Rat

Cited by 15 publications

References 5 publications

Olfactory recognition memory is disrupted in young mice with chronic low-level lead exposure

Olfactory recognition memory is disrupted in young mice with chronic low-level lead exposure

Early chronic lead exposure reduces exploratory activity in young C57BL/6J mice

Microglial disruption in young mice with early chronic lead exposure

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