Impact of latency time on survival for adolescents and young adults with a second primary malignancy

Goldfarb, Melanie; Rosenberg, Aaron S; Li, Qian; Keegan, Theresa H.M.

doi:10.1002/cncr.31170

Cited by 15 publications

(18 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Keegan et al (30) found that a previous cancer history was associated with a worse prognosis in patients with Hodgkin lymphoma, sarcoma, or breast, thyroid, or testicular cancers. A similar finding was also reported by Chao et al (22); moreover, recently, Goldfarb et al (31) noted that a longer latency time (>5 years) suggested an overall increased risk of death. However, none of these studies enrolled patients with head and neck MEC.…”

Section: Figure 2 |supporting

confidence: 84%

Comparison Between Primary and Secondary Pediatric Mucoepidermoid Carcinoma of the Head and Neck

Shi

2020

Front. Pediatr.

View full text Add to dashboard Cite

Objectives: Secondary mucoepidermoid carcinoma (MEC) of the head and neck is occasionally observed in childhood cancer survivors. The goal of this research was to compare the demographic and pathologic characteristics, as well as survival between primary and secondary MEC in children and adolescent patients. Methods: Pediatric patients (younger than 19 years old) with surgically treated MEC of the head and neck were retrospectively enrolled at the Affiliated Children's Hospital of Zhengzhou University and divided into two groups based on their cancer history. Demographic, pathologic, and survival characteristics between the two groups were compared. The main study interests were recurrence-free survival (RFS), overall survival (OS), and disease-specific survival (DSS). Results: The primary and secondary groups consisted of 63 and 15 patients, respectively. The two groups had similar distributions in terms of age, sex, tumor stage, neck lymph node stage, perineural invasion, lymphovascular invasion, p53, Bcl-2, proliferating cell nuclear antigen, carcinoembryonic antigen, and Ki-67 index. The 10-year RFS rates for the primary group and secondary group were 80 and 71%, respectively, and this difference was not significant (p = 0.464). The 10-year DSS rates for the primary group and secondary group were 83 and 82%, respectively, and this difference was also not significant (p = 0.649). The 10-year OS rates for the primary group and secondary group were 74 and 51%, respectively; this difference was significant (p = 0.023). Further Cox model analysis confirmed the independence of a previous cancer history (p = 0.043) in decreasing OS. Conclusions: Pediatric patients with secondary MEC exhibit similar demographic, pathologic, and molecular characteristics as primary patients but worse OS. These findings indicate that special disease management approaches might be needed for secondary patients.

show abstract

Section: Figure 2 |supporting

confidence: 84%

Comparison Between Primary and Secondary Pediatric Mucoepidermoid Carcinoma of the Head and Neck

Shi

2020

Front. Pediatr.

View full text Add to dashboard Cite

show abstract

“…19 Survivors of pediatric malignancies in the Childhood Cancer Survivor Study who previously were treated with abdominal radiation experienced an 11-fold increased risk of gastrointestinal SMNs. 11 A shorter latency time of within 1 to 5 years between the first cancer diagnosis and the SMN demonstrates an increased risk of death compared with a longer latency interval. 10 The British Childhood Cancer Survivor Study reported a cumulative incidence of CRC by age 50 years of 1.4% (95% CI, 0.7%-2.6%) for survivors treated with abdominopelvic irradiation, similar to rates observed in individuals with ≥2 first-degree relatives diagnosed with CRC.…”

Section: Discussionmentioning

confidence: 99%

“…10 Latency time from initial diagnosis to the diagnosis of an SMN also has been shown to be a factor in survival outcomes. 11 A shorter latency time of within 1 to 5 years between the first cancer diagnosis and the SMN demonstrates an increased risk of death compared with a longer latency interval. Specifically, a colon SMN occurring within 5 years conferred a 9-fold increased risk of death compared with one with a latency period of >6 years.…”

Section: Discussionmentioning

confidence: 99%

“…1 CRC in this population has shown a tendency toward left-sided cancers, but the incidence and percentage of right-sided cancers also is increasing among patients aged 40 to 49 years. [9][10][11] CRC is one of the important SMNs whose prevalence and morbidity, both early and late in survivorship, are emerging in aging cohorts of young survivors. 8 CRC in younger adults can occur de novo or as a subsequent malignant neoplasm (SMN) in patients previously treated for another cancer.…”

Section: Introductionmentioning

confidence: 99%

“…Although the survival rates for childhood cancers have improved to >80%, solid SMNs have emerged as a significant cause of early mortality in survivors, especially when diagnosed early in the survivorship period. [9][10][11] CRC is one of the important SMNs whose prevalence and morbidity, both early and late in survivorship, are emerging in aging cohorts of young survivors. 12 Investigators from the Childhood Cancer Survivor Study, Late Effects Study Group, and British Childhood Cancer Survivor Study have observed a 0.1% to 2.4% cumulative incidence of subsequent CRC at 30 years.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Colon cancer as a subsequent malignant neoplasm in young adults

Teng

Nelson

Dehal

et al. 2019

Cancer

Self Cite

View full text Add to dashboard Cite

BACKGROUND: The incidence of colon cancer (CC) is rising in younger adults and can occur de novo or in patients previously treated for another cancer. To the authors' knowledge, the impact on survival of CC occurring as a subsequent malignant neoplasm (SMN) has not been described for younger patients, which the authors anticipate to be lower with SMNs than that of primary CC. METHODS: Patients aged <50 years with CC in the 2004 through 2014 National Cancer Data Base were identified. Patients were stratified by primary or subsequent occurrence. The impact of SMN status on overall survival (OS) was evaluated. RESULTS: Of 41,915 patients, 2852 (6.8%) had colon SMNs. More patients with colon SMNs were aged 40 to 49 years compared with patients with primary CC (83% vs 77%; P < .001). Patients with colon SMNs presented with earlier clinical and pathological T, N, and M classifications (all P < .001). Colon SMNs more commonly occurred in the right colon, whereas primary CC was found to have a higher prevalence in the sigmoid colon (P < .001). Patients with colon SMNs more frequently underwent total colectomy (17% vs 5%; P < .001), but received less chemotherapy (53% vs 65%; P < .001). When adjusted for demographic, tumor, and treatment characteristics, SMN status was associated with a 23% decreased OS compared with primary CC (95% CI, 1.14-1.31; P < .001). Chemotherapy offered a 33% improvement in OS (95% CI, 0.56-0.8; P < .001). CONCLUSIONS: Colon SMNs in younger patients present at an earlier stage and are treated more aggressively surgically compared with primary CCs. Patients with SMNs of the colon have decreased survival, although chemotherapy offers a survival advantage. Further investigation is warranted to determine whether these disparities are due to the effects of cancer treatment or differences in tumor biology. Cancer 2019;125:3749-3754.

show abstract

Nomograms constructed for predicting diagnosis and prognosis in cervical cancer patients with second primary malignancies: a SEER database analysis

Xie¹,

Lin²,

Liu³

et al. 2023

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

Impact of latency time on survival for adolescents and young adults with a second primary malignancy

Abstract: Most AYAs who develop an SPM do so within 1 to 5 years of their primary cancer diagnosis, and they have an increased risk of death from cancer in comparison with AYAs with an SPM developing after longer survivorship intervals. Cancer 2018;124:1260-8. © 2017 American Cancer Society.

Cited by 15 publications

References 38 publications

Comparison Between Primary and Secondary Pediatric Mucoepidermoid Carcinoma of the Head and Neck

Comparison Between Primary and Secondary Pediatric Mucoepidermoid Carcinoma of the Head and Neck

Colon cancer as a subsequent malignant neoplasm in young adults

Nomograms constructed for predicting diagnosis and prognosis in cervical cancer patients with second primary malignancies: a SEER database analysis

Contact Info

Product

Resources

About