Impact of lactoferrin on bone regenerative processes and its possible implementation in oral surgery – a systematic review of novel studies with metanalysis and metaregression

Abstract

Background: Lactoferrin is an ironbinding glycoprotein with anti-inflammatory and anabolic properties found in many internal fluids. It is worth looking at novel studies, because of their methodology and observations that may once be applicable in modern implantology. The aim of the study is to answer the question if lactoferrin is a promising factor for bone regenerative process in oral surgery. Method: An electronic search was conducted on 14th October 2019 on the PubMed, Scopus and Web of Science databases. The keywords used in the search strategy were: lactoferrin AND bone regeneration AND oral surgery. The qualitative evaluation was conducted using the Jadad and Newcastle-Ottawa Quality Assessment Form. Then a metanalysis of a new bone growth and percentage of the resorbed graft were performed with the metaregression of lactoferrin dose to its outcome effects on bone regeneration. Results: The search strategy identified potential articles: 133 from PubMed, 2 from Scopus, 4 from Web of science. After removal of duplicates, 136 articles were analyzed. Subsequently, 131 papers were excluded because they did not meet the inclusion criteria. The remaining 5 papers were included in the qualitative synthesis. The use of lactoferrin clearly increases the growth of a newly formed bone (2.58, CI:[0.79, 4.37]), as well as shortens the time of the graft resorption (− 1.70, Cl:[3.43, 0.03]) and replaces it with a species-specific bone. Heterogeneity is significant at p < 0.001 level. Metaregression indicates that one unit increase in the log (Treatment dose), i.e. a 2.78 times increase of the Treatment dose, results in an increase of the Effect size by 0.682.

The Evaluation of the Periodontal Status of Hemodialysis Patients with End-Stage Renal Disease

“…Postbiotics or lactoferrin in oral surgery or periodontology to support the treatment of periodontal disease, among others, is increasingly discussed in the literature [44,45]. These are mostly natural substances, which may support the treatment of periodontal diseases to the same extent as chlorhexidine.…”

Colostrum-Induced Temporary Changes in the Expression of Proteins Regulating the Epithelial Barrier Function in the Intestine

“…Lf was shown to have anti-cancer, anti-viral, anti-bacterial, anti-inflammatory [ 3 ], and anti-fungal properties [ 4 ]. It also ameliorates, inter alia, hypertension [ 5 ], gastrointestinal ulcers [ 6 ], cardiovascular diseases [ 7 , 8 ] or bone regeneration [ 9 ]. More importantly, Lf was shown to be an important regulator of the gastrointestinal immune response [ 10 ] and can affect the expression of some tight junction (TJ) proteins in vitro [ 11 ].…”

Impact of the 25-Hydroxycholecalciferol Concentration and Vitamin D Deficiency Treatment on Changes in the Bone Level at the Implant Site during the Process of Osseointegration: A Prospective, Randomized, Controlled Clinical Trial

“…In the formation of new bone, during the first weeks after surgery, these fragments seem to be of significant importance, and it is suggested that they should not be removed from the bed after its preparation. Many studies have shown that various growth and differentiation factors, such as BMP and lactoferrin, enhance bone regeneration [ 7 , 8 , 9 , 10 , 11 ].…”