Impact of Lactic Acid and Genipin Concentration on Physicochemical and Mechanical Properties of Chitosan Membranes

Kondratowicz, Izabela; Shalayel, Ibrahim; Nadolska, Małgorzata; Tsujimura, Seiya; Yamagata, Yuriko; Shitanda, Isao; Zebda, Abdelkader

doi:10.1007/s10924-022-02691-z

Cited by 5 publications

(7 citation statements)

References 48 publications

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“…Genipin usually requires heating (around 70 °C) in order to initiate its crosslinking activity with amine‐containing biomaterials [20] . For this reason, we chose to study the effect of such elevated temperatures on the stability of genipin over time.…”

Section: Resultsmentioning

confidence: 99%

“…[21,22] Genipin usually requires heating (around 70 °C) in order to initiate its crosslinking activity with amine-containing biomaterials. [20] For this reason, we chose to study the effect of such elevated temperatures on the stability of genipin over time. Upon heating at 70 °C, we observed the appearance of aldehyde peaks around 10 ppm, which correspond to two open-form structures of genipin.…”

Section: Resultsmentioning

confidence: 99%

“…Temperature might not be well regulated during the preparation of biopolymers. For example, the protocol of chitosan preparation includes heating an acidic chitosan solution at about 70 °C, [20,23] however, temperatures higher than 70 °C will also succeed in dissolving chitosan chains, [24] and relatively vigorous temperatures may also be used to treat chitosan materials. [25] We aimed to examine the possible negative effect of elevated temperatures on the stability of genipin and, thus, on its crosslinking efficiency.…”

Section: Resultsmentioning

confidence: 99%

“…For this reason, we found it crucial to examine the stability of genipin in the neutral and acidic conditions in which genipin crosslinker is classically used. Moreover, in the case of materials such as chitosan, crosslinking with genipin is often performed at a relatively high temperature (>60 °C) to allow chitosan solubilization [20] . To the best of our knowledge, there are no reported studies on the effect of high temperature on the behavior of genipin and its polymerization process.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, in the case of materials such as chitosan, crosslinking with genipin is often performed at a relatively high temperature (> 60 °C) to allow chitosan solubilization. [20] To the best of our knowledge, there are no reported studies on the effect of high temperature on the behavior of genipin and its polymerization process.…”

Section: Introductionmentioning

confidence: 99%

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Study of Genipin Behavior in Neutral and Acidic Aqueous Solutions at Elevated Temperatures

2023

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Genipin is known to polymerize under basic conditions, and the obtained genipin oligomers might have an impact on the chemical and physical properties of the crosslinked materials. In this study, we intend to mimic the experimental condition in which genipin is used as a chemical crosslinker. We focus on the degradation of genipin at neutral and slightly acidic conditions using NMR. We report genipin polymerization at neutral and acidic conditions. Unlike dialdehyde crosslinkers, genipin requires heating to promote its crosslinking activity. We found that elevated temperatures enhance the degradation of genipin and promote its polymerization.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Study of Genipin Behavior in Neutral and Acidic Aqueous Solutions at Elevated Temperatures

2023

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Insight into continuous glucose monitoring: from medical basics to commercialized devices

et al. 2023

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According to the latest statistics, more than 537 million people around the world struggle with diabetes and its adverse consequences. As well as acute risks of hypo-or hyper-glycemia, long-term vascular complications may occur, including coronary heart disease or stroke, as well as diabetic nephropathy leading to end-stage disease, neuropathy or retinopathy. Therefore, there is an urgent need to improve diabetes management to reduce the risk of complications but also to improve patient's quality life. The impact of continuous glucose monitoring (CGM) is well recognized, in this regard. The current review aims at introducing the basic principles of glucose sensing, including electrochemical and optical detection, summarizing CGM technology, its requirements, advantages and disadvantages. The role of CGM systems in the clinical diagnostics/personal testing, difficulties in their utilization and recommendations are also discussed. In the end, challenges and prospects in future CGM systems are discussed and non-invasive, wearable glucose biosensors are introduced. Though the scope of this review is CGMs and provides information about medical issues and analytical principles, consideration of broader use will be critical in future if the right systems are to be selected for effective diabetes management.

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Preparation of acrolein/resveratrol-grafted chitosan-sodium alginate bilayer films and their antibacterial and antioxidant activities

Guo,

Jiang,

et al. 2024

Food Hydrocolloids

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Impact of Lactic Acid and Genipin Concentration on Physicochemical and Mechanical Properties of Chitosan Membranes

Cited by 5 publications

References 48 publications

Study of Genipin Behavior in Neutral and Acidic Aqueous Solutions at Elevated Temperatures

Study of Genipin Behavior in Neutral and Acidic Aqueous Solutions at Elevated Temperatures

Insight into continuous glucose monitoring: from medical basics to commercialized devices

Preparation of acrolein/resveratrol-grafted chitosan-sodium alginate bilayer films and their antibacterial and antioxidant activities

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