Impact of knee osteoarthritis on the quality of life among Saudi elders: A comparative study

Alrushud, Asma; El-Sobkey, Salwa B.; Hafez, Ashraf Ramadan; Al-Ahaideb, Abdulaziz

doi:10.4103/1319-6308.112207

Cited by 15 publications

(8 citation statements)

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“…In the current study, the older adults with arthritis showed significantly different levels of HRQOL depending on their age; however, no difference was found for the older adults without arthritis. This is similar to the previous studies that found that older adults with arthritis reported lower quality of life than older adults without arthritis [27,28], the quality of life is worse as age increases [29]. We also need to consider HRQOL based on cultural background because family social support influences successful aging and quality of life in the Korean older adults [30,31].…”

Section: Discussionsupporting

confidence: 85%

Social networks, health-promoting behaviors, and health-related quality of life in older adults with and without arthritis

2019

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The purpose of this secondary analysis study was to compare social networks, health-promoting behaviors, and health-related quality of life of South Korean adults, aged 65 years or older, with and without arthritis, and to identify factors that are related to health-related quality of life. The sample consisted of 103 adults with arthritis and 123 adults without arthritis. Data were analyzed using a two-way analysis of variance, χ 2 -test, Pearson’s correlation, and multiple regression analysis. All variables except age and religion showed statistically significant differences between older adults with and without arthritis. The group with arthritis reported lower scores on social networks, health-promoting behaviors, and health-related quality of life compared to the healthy group without arthritis. Analyzed using multiple regression, 43.8% of the older adults with arthritis had the factors related to health-related quality of life ( F = 40.71, p < .001) including exercise (β = .43, p < .001) and living with someone (β = .32, p = .001). In the group of older adults without arthritis, 26.2% had the factors related to health-related quality of life ( F = 15.44, p < .001) including exercise (β = .31, p = .001), social gatherings, and employment status. Exercise was one of the factors that showed the strongest relationship to health-related quality of life. The provision of resources that can enable an individual to engage in physical activities is warranted.

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Section: Discussionsupporting

confidence: 85%

Social networks, health-promoting behaviors, and health-related quality of life in older adults with and without arthritis

2019

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“…In line with global data, the prevalence of OA was high in the elderly population (30.8 % in those aged 46–55 years and 60.6 % in those aged 66–75 years) [8]. Another recent study found that elderly Saudi patients with OA had significantly higher pain scores and physical disability than those without OA, leading to a negative impact on their quality of life [9]. Clearly, there is an important role for pain medications in the management of OA in Saudi Arabia.…”

Section: Introductionmentioning

confidence: 75%

The cost-effectiveness of celecoxib versus non-steroidal anti-inflammatory drugs plus proton-pump inhibitors in the treatment of osteoarthritis in Saudi Arabia

et al. 2015

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BackgroundCyclooxygenase (COX)-2 inhibitors including celecoxib are as effective as non-selective non-steroidal anti-inflammatory drugs (ns-NSAIDs) in the treatment of osteoarthritis (OA) and have less gastrointestinal toxicity. Although they are associated with higher treatment costs, COX-2 inhibitors may simultaneously reduce costs associated with adverse events, hence, their overall economic benefit should be assessed.ObjectiveTo evaluate the incremental cost effectiveness ratio (ICER) of celecoxib versus ns-NSAIDs, with/without proton-pump inhibitor (PPI) co-therapy, for managing OA in Saudi Arabian subjects aged ≥65 years.MethodsThe National Institute for Health and Care Excellence health economic model from the UK, updated with relative risks of adverse events using CONDOR trial data, was adapted. Patients received celecoxib or ns-NSAIDs, with/without omeprazole. The effectiveness measure was quality-adjusted life years (QALYs) gained per patient. The analysis was conducted from the patient’s perspective. Frequencies of resource use for adverse events were based on data collected in July 2012 from seven private hospitals in Jeddah, Saudi Arabia. Probabilistic sensitivity analysis was performed to construct cost-effectiveness acceptability curves (CEACs).ResultsOver a 6-month treatment duration, QALYs gained per patient were higher with celecoxib (0.37) and celecoxib plus PPI (0.40) versus comparators. Ibuprofen plus PPI showed the lowest expected cost per patient (US$ 1,314.50 versus US$ 1,422.80 with celecoxib plus PPI and US$ 1,543.50 with celecoxib). Celecoxib plus PPI was the most cost-effective option with an ICER of US$ 1,805.00, followed by celecoxib (ICER, US$ 7,633.33) versus ibuprofen plus PPI. Over 2- and 5-year treatment durations, celecoxib plus PPI, and celecoxib, showed higher QALYs gained/patient and lower ICERs versus comparators. These ICERs are <1 gross domestic product/capita in Saudi Arabia in 2013 (US$ 25,961).CEACs over 6 months’ treatment showed a significantly higher likelihood that celecoxib plus PPI and celecoxib alone would be more cost effective versus comparators once the willingness to pay is over US$ 2,000.00.ConclusionAfter considering new adverse event risks, celecoxib with/without PPI co-therapy was deemed very cost effective for medium- and long-term use in Saudi Arabian OA patients aged ≥65 years.

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“…The present study also demonstrated that increased disease duration was associated lower physical activity among knee and hip OA patients. Another study reported that patients' QOL was negatively correlated with disease duration, indicating the longer disease duration, the worse QOL 16 . Another study also supported that an increased OA disease duration was significantly associated with low HRQOL 17 .…”

Section: Discussionmentioning

confidence: 99%

Determinants of Health-Related Quality of Life in Patients with Knee and Hip Osteoarthritis under Rehabilitation Care

Zamri

Harith

Yusoff

et al. 2020

Asian Journal of Pharmaceutical Research and Health Care

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The World Health Organization estimated Osteo-Arthritis (OA) to cause 80% sufferers to have movement limitation and 25% unable to perform major daily activities, which result in quality of life deterioration. This study aims to determine the factors associated with Health-Related Quality Of Life (HRQOL). A total of 131 OA patients were involved in a crosssectional study which were recruited from the Rehabilitation Health Organization, Terengganu. Socio-demographic, clinical and lifestyle histories, and 24-hour dietary intake were assessed by using structured questionnaire while HRQOL was measured by using the Malay version of the Osteo-Arthritis Knee and Hip Quality Of Life (OAKHQOL) questionnaire. OAKHQOL questionnaire was evaluated via Likert scales in the items range from 0 (best) to 10 (worst). In each domain, the mean score of the items was calculated, yielding a score for each domain. The score is the standardized on a scale from 0 (best possible QOL) to 100 (worst possible QOL) scale. Anthropometric measurement was measured by using Tanita Body Fat Monitor and Seca height scale and Body Mass Index (BMI) was calculated. Multiple linear regression was performed. Age was positively associated with social functioning (p=0.005). Meanwhile, disease duration was positively associated with physical domain (p=0.043). Among the anthropometric measurement, only BMI was positively associated with physical domain (p=0.040). Higher vitamins C and D intake was associated with lower mental health. Next, better social functioning was observed in low vitamin K consumption. Patients who exercise were associated with better physical and mental health, lower pain, and greater social support. Monthly income, body mass index, waist circumference, and other nutrients intake were not associated with HRQOL. In summary, exercise was the best predictor for better HRQOL.

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Impact of knee osteoarthritis on the quality of life among Saudi elders: A comparative study

Cited by 15 publications

References 0 publications

Social networks, health-promoting behaviors, and health-related quality of life in older adults with and without arthritis

Social networks, health-promoting behaviors, and health-related quality of life in older adults with and without arthritis

The cost-effectiveness of celecoxib versus non-steroidal anti-inflammatory drugs plus proton-pump inhibitors in the treatment of osteoarthritis in Saudi Arabia

Determinants of Health-Related Quality of Life in Patients with Knee and Hip Osteoarthritis under Rehabilitation Care

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