Impact of Italian Score for Organ Allocation System on Deceased Donor Liver Transplantation: A Monocentric Competing Risk Time-to-Event Analysis

Khouzam, Simone; Pagano, Domenico; Barbàra, Marco; Cintorino, Davide; Petri, Sergio Li; Francesco, Fabrizio di; Ricotta, Calogero; Bonsignore, Pasquale; Seidita, Aurelio; Calamia, Sergio; Canzonieri, Marco; Tropea, Alessandro; Gruttadauria, Salvatore

doi:10.1016/j.transproceed.2019.02.073

Cited by 6 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Italian Board of Experts in the Field of Liver Transplantation has developed the ISO system, incorporating a priority criterion for MELD exception conditions (39). In our previous monocentric case study (40), there was clearly a significant reduction in deaths while waiting for a liver, and an increase in the percentage of LT recipients with the application of the ISO score, though this would have to be validated The positive aspects of this system are simplicity, objectivity, and transparency, but the prognostic ability of the D-MELD is lacking in LT centers using a more complex D-R matching policy (9). The difficulty in identifying an effective score is due to the myriad of variables to be considered in the match between donor and recipient in each transplant.…”

Section: Italian Score For Organ Allocation (Iso) Systemmentioning

confidence: 99%

Donor-recipient matching in adult liver transplantation: Current status and advances

Accardo

Vella

Pagano

et al. 2023

BST

Self Cite

View full text Add to dashboard Cite

Pagano D. et al. (14) Chapman WC et al. (11) Gilbo N. et al. (10) Nakamura T. et al. (12) Caso maestro O. et al. (15) Levesque E. et al. (21) Croome KP et al. (22) KW Ma et al. (20) Reyes J. et al. (19) Kubal CA et al. (24) Addeo P. et al. (25) Kostakis ID et al. (23) Rustgi VK et al. (26) Lehner F. et al. (28) Schoening WN et al. (27) Lai Q. et al. (29) Germani G. et al. (30) Conclusions Donor age >70 y among the criteria for defining a suboptimal liver. Age mismatch is an independent risk factor for patient death. Comparable outcomes in graft and patient survivals using older donors (> 60 y) without increased rate of complications. Older livers can be safely used in older recipients if other risk factors are minimized.Elderly liver grafts exhibit slower recovery trajectories in the acute phase but finally achieve acceptable outcomes.

show abstract

Section: Italian Score For Organ Allocation (Iso) Systemmentioning

confidence: 99%

Donor-recipient matching in adult liver transplantation: Current status and advances

Accardo

Vella

Pagano

et al. 2023

BST

Self Cite

View full text Add to dashboard Cite

show abstract

“…While LT is the definitive treatment of these curative treatment options, the possibility of recurrence, waiting list times, and limited organ supply require consideration of LR prior to LT. Italy's organ allocation system uses the ISO score, a blended model of urgency, utility, and transplant benefit [3,4] . Given the high likelihood of RHCC, post-transplant recurrence and outcomes must be considered [5,6] .…”

Section: Introductionmentioning

confidence: 99%

Protective benefit of minimally invasive liver surgery for hepatocellular carcinoma prior to transplant

Khouzam¹,

Pagano²,

Barbàra³

et al. 2022

Self Cite

View full text Add to dashboard Cite

Aim: The purpose of this study is to assess the benefit of laparoscopic liver resection (LLR) for hepatocellular carcinoma (HCC) given recurrence and future need for liver transplantation (LT). Methods: Data on liver resections were gathered from the Istituto di Ricovero e Cura a Carattere Scientifico-Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione (IRCCS-ISMETT) from 2003-2021. A retrospective analysis of 1408 consecutive adult patients who had a liver resection was performed with categorization based on the underlying disease process. A sub-analysis studied the 291 patients who had an LLR with an intention to transplant approach after LLR. Results: From 2012 to 2020, ISMETT’s mean annual LLR rate was 45%. Data suggests that a laparoscopic approach to iterative surgical treatment for HCC has demonstrated protective benefits. Compared to open surgery or LT, LLR is protective against the risk of de-listing, post-transplant patient death, tumor recurrence, adhesions, and bleeding in a cirrhotic patient. Kaplan Meier’s analysis showed no difference between post-LT survival curves for those with prior open abdominal surgery or LLR (P = 0.658). Conclusion: Laparoscopic surgery has important protective advantages over laparotomy surgery for the surgical treatment of HCC, particularly since treatment is not always curative. LLR can be considered a bridge therapy for transplantation, ensuring less crowding of waiting lists, a desirable condition in areas of donor storage.

show abstract

Surgical Management of Hepatocellular Carcinoma

Pagano¹,

Mamone²,

Calamia³

et al. 2021

Hepato-Pancreato-Biliary Malignancies

View full text Add to dashboard Cite

Impact of Italian Score for Organ Allocation System on Deceased Donor Liver Transplantation: A Monocentric Competing Risk Time-to-Event Analysis

Cited by 6 publications

References 11 publications

Donor-recipient matching in adult liver transplantation: Current status and advances

Donor-recipient matching in adult liver transplantation: Current status and advances

Protective benefit of minimally invasive liver surgery for hepatocellular carcinoma prior to transplant

Surgical Management of Hepatocellular Carcinoma

Contact Info

Product

Resources

About